2008
Molecular Pathology and Transcriptional Profiling in Early Drug Development
Liedtke C, Pusztai L, Symmans W. Molecular Pathology and Transcriptional Profiling in Early Drug Development. 2008, 47-84. DOI: 10.1002/9780470475959.ch3.Peer-Reviewed Original ResearchNeoadjuvant chemotherapyClinical settingMultigene predictorsBiomarker developmentClinical drugsIntroduction BiomarkersTranscriptional profilingEarly drug developmentMolecular pathologyBiomarkersChanging ParadigmChemotherapyDrug developmentNovel toolDrugsIntriguing modelPredictorsSettingPathologyProfiling
2005
Development of pharmacogenomic markers to select preoperative chemotherapy for breast cancer
Lajos P, Symmans F, Hortobagyi G. Development of pharmacogenomic markers to select preoperative chemotherapy for breast cancer. Breast Cancer 2005, 12: 73-85. PMID: 15858436, DOI: 10.1007/bf02966817.Peer-Reviewed Original ResearchConceptsBreast cancerJapanese Breast Cancer SocietyTexas M. D. Anderson Cancer CenterM. D. Anderson Cancer CenterD. Anderson Cancer CenterEffective adjuvant chemotherapyBreast Cancer SocietyAnderson Cancer CenterAdjuvant chemotherapyCombination of markersPreoperative chemotherapyNew regimensCancer CenterCurrent therapiesBreast centerCancer SocietySmall exploratory studyIndividualized selectionPharmacogenomic markersChemotherapyCancerMolecular characteristicsMarkersTranscriptional profilingAnnual MeetingDevelopment of Pharmacogenomic Markers to Select Preoperative Chemotherapy for Breast Cancer
Pusztai L, Symmans FW, Hortobagyi GN. Development of Pharmacogenomic Markers to Select Preoperative Chemotherapy for Breast Cancer. Breast Cancer 2005, 12: 73-85. DOI: 10.2325/jbcs.12.73.Peer-Reviewed Original ResearchConceptsBreast cancerJapanese Breast Cancer SocietyTexas M. D. Anderson Cancer CenterM. D. Anderson Cancer CenterD. Anderson Cancer CenterEffective adjuvant chemotherapyBreast Cancer SocietyAnderson Cancer CenterAdjuvant chemotherapyCombination of markersPreoperative chemotherapyNew regimensCancer CenterCurrent therapiesBreast centerCancer SocietySmall exploratory studyIndividualized selectionPharmacogenomic markersChemotherapyCancerMolecular characteristicsMarkersTranscriptional profilingAnnual Meeting
2004
Individualized chemotherapy treatment for breast cancer: is it necessary? Is it feasible?
Pusztai L, Rouzier R, Wagner P, Symmans WF. Individualized chemotherapy treatment for breast cancer: is it necessary? Is it feasible? Drug Resistance Updates 2004, 7: 325-331. PMID: 15790543, DOI: 10.1016/j.drup.2004.10.002.Peer-Reviewed Original ResearchConceptsChemotherapy regimensChemotherapy treatmentPatient outcomesBreast cancerClinical utilitySmall exploratory studyIndividualized selectionClinical pharmacogenomicsPredictive testUseful predictorCancerMolecular characteristicsMarker researchTranscriptional profilingRegimensValidation trialsChemotherapyTrialsPharmacogenomics
Ross JS, Schenkein DP, Kashala O, Linette GP, Stec J, Symmans WF, Pusztai L, Hortobagyi GN. Pharmacogenomics. Advances In Anatomic Pathology 2004, 11: 211-220. PMID: 15220824, DOI: 10.1097/01.pap.0000131825.77317.ee.Peer-Reviewed Original ResearchConceptsDisease pathway genesGene expression patternsWhole-genome technologiesHuman genomeTranscriptional profilingGenome technologyPathway genesMolecular basisGenomic microarraysSNP technologySolid Tumors (RECIST) classificationExpression patternsTarget discoveryProteomics researchDrug targetsGenetic variantsNon-genetic factorsAnti-cancer drugsComputational biologyVariety of diseasesField of pharmacogeneticsDrug metabolizing enzymesToxic responseLeukemia/lymphomaGroup of drugsBreast cancer biomarkers and molecular medicine: part II
Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, Symmans WF, Hortobagyi GN, Pusztai L. Breast cancer biomarkers and molecular medicine: part II. Expert Review Of Molecular Diagnostics 2004, 4: 169-188. PMID: 14995904, DOI: 10.1586/14737159.4.2.169.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsCell Adhesion MoleculesDNADrug Resistance, MultipleEndopeptidasesFemaleGene Expression ProfilingGenes, Tumor SuppressorHumansOncogenesPharmacogeneticsPrognosisProto-Oncogene Proteins c-bcl-2Receptors, EstrogenReceptors, ProgesteroneTelomeraseTranscription FactorsConceptsInvasion-associated proteinsMolecular medicineTumor suppressor geneTranscriptional profilingTranscription factorsDNA repairCell adhesion moleculeDrug resistance proteinsGenomic microarraysApoptosis regulatorSuppressor geneHormone receptor proteinsReceptor proteinBreast cancer biomarkersResistance proteinCancer biomarkersProteinBreast cancer prognostic factorsAdhesion moleculesCancer prognostic factorsPrognostic factorsTherapy responseGenesMethylationTelomerase
2003
Breast cancer biomarkers and molecular medicine
Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, Symmans WF, Hortobagyi GN, Pusztai L. Breast cancer biomarkers and molecular medicine. Expert Review Of Molecular Diagnostics 2003, 3: 573-585. PMID: 14510178, DOI: 10.1586/14737159.3.5.573.Peer-Reviewed Original ResearchConceptsCell cycle regulatorsInvasion-associated proteinsTumor suppressor geneTranscription factorsTranscriptional profilingDNA repairGrowth factor receptorCell adhesion moleculeDrug resistance proteinsGenomic microarraysCycle regulatorsBreast cancer biomarkersPrognostic factorsApoptosis regulatorEpithelial growth factor receptorSuppressor geneHormone receptor proteinsBreast cancer predispositionCancer predispositionReceptor proteinCytogenetic markersResistance proteinBreast cancer prognostic factorsCancer biomarkersFactor receptorClinical Application of cDNA Microarrays in Oncology
Pusztai L, Ayers M, Stec J, Hortobágyi GN. Clinical Application of cDNA Microarrays in Oncology. The Oncologist 2003, 8: 252-258. PMID: 12773747, DOI: 10.1634/theoncologist.8-3-252.Peer-Reviewed Original ResearchConceptsHundreds of genesGene expression patternsSingle-gene markersIndividual genesTranscriptional profilingCDNA microarrayMRNA speciesDNA microarraysExpression patternsComplex biologyNovel targetImportant new toolMicroarrayClinical outcomesGenesHuman tissuesImportant clinical outcomesDiseased tissuesDrug developmentTrue clinical utilityClinical utilityClinical OncologyNew toolBiologyExciting new technologyTotal RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma
Symmans WF, Ayers M, Clark EA, Stec J, Hess KR, Sneige N, Buchholz TA, Krishnamurthy S, Ibrahim NK, Buzdar AU, Theriault RL, Rosales MF, Thomas ES, Gwyn KM, Green MC, Syed AR, Hortobagyi GN, Pusztai L. Total RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma. Cancer 2003, 97: 2960-2971. PMID: 12784330, DOI: 10.1002/cncr.11435.Peer-Reviewed Original ResearchConceptsGene expression profilesTranscriptional profilesExpression profilesFine-needle aspiration biopsyGenomic databasesStromal gene expressionGene expressionTotal RNA yieldTotal RNABreast carcinomaTumor cell populationSubset of genesCDNA microarray analysisStromal cellsBiopsy samplesGene expression profilingCell populationsMicroscopic cell countsRNA yieldAspiration biopsyGenomic studiesTranscriptional profilingCDNA microarrayNonlymphoid stromal cellsExpression profiling