2023
Associations amongst genes, molecules, cells, and organs in breast cancer metastasis
Nathanson S, Dieterich L, Zhang X, Chitale D, Pusztai L, Reynaud E, Wu Y, Ríos-Hoyo A. Associations amongst genes, molecules, cells, and organs in breast cancer metastasis. Clinical & Experimental Metastasis 2023, 41: 417-437. PMID: 37688650, DOI: 10.1007/s10585-023-10230-w.Peer-Reviewed Original ResearchBreast cancer metastasisBreast cancerCancer metastasisOutcomes of patientsAnti-tumor immunityHope of cureAggressive therapyMultiple metastasesAggressive treatmentBone metastasesLymph nodesSystemic metastasesMorphologic subtypesClinical oncologistsMetastasisInternal visceraAssists cliniciansLymphatic endothelial cellsPatientsEndothelial cellsHealth SymposiumBasic scientistsMolecular expressionCancerMolecular aspects
2020
Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers
Rozenblit M, Huang R, Danziger N, Hegde P, Alexander B, Ramkissoon S, Blenman K, Ross JS, Rimm DL, Pusztai L. Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers. Journal For ImmunoTherapy Of Cancer 2020, 8: e001558. PMID: 33239417, PMCID: PMC7689582, DOI: 10.1136/jitc-2020-001558.Peer-Reviewed Original ResearchConceptsPD-L1 positivity ratePD-L1 positivityPD-L1 expressionDifferent metastatic sitesPrimary tumorMetastatic sitesPositivity rateImmune cellsMetastatic lesionsTumor cellsPD-L1 protein expressionTriple-negative breast cancerMore primary tumorsTriple negative breast cancer tumorsPrimary breast lesionsPrimary outcome measureSoft tissueNegative breast cancerLow positivity rateBreast cancer tumorsBone metastasesFoundation MedicineLymph nodesPD-L1Spearman correlation coefficient
2017
Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status
Hayashi N, Iwamoto T, Qi Y, Niikura N, Santarpia L, Yamauchi H, Nakamura S, Hortobagyi GN, Pusztai L, Symmans WF, Ueno NT. Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status. Journal Of Cancer 2017, 8: 1045-1052. PMID: 28529618, PMCID: PMC5436258, DOI: 10.7150/jca.13690.Peer-Reviewed Original ResearchER-negative breast cancerEstrogen receptor statusBone metastasesER statusBreast cancerReceptor statusHuman epidermal growth factor receptor 2Breast cancer bone metastasisEpidermal growth factor receptor 2Cox proportional hazards modelNon-bone metastasisGrowth factor receptor 2Cancer bone metastasisProportional hazards modelBreast cancer specimensInvasive breast cancer specimensFactor receptor 2Negative cohortCancer specimensHazards modelReceptor 2BCBMMetastasisCancerCohort
2012
Elevated serum P1NP predicts development of bone metastasis and survival in early-stage breast cancer
Dean-Colomb W, Hess KR, Young E, Gornet TG, Handy BC, Moulder SL, Ibrahim N, Pusztai L, Booser D, Valero V, Hortobagyi GN, Esteva FJ. Elevated serum P1NP predicts development of bone metastasis and survival in early-stage breast cancer. Breast Cancer Research And Treatment 2012, 137: 631-636. PMID: 23242617, PMCID: PMC3867793, DOI: 10.1007/s10549-012-2374-0.Peer-Reviewed Original ResearchConceptsBreast cancerBone metastasesStage IP1NP levelsSerum levelsIL-6Procollagen type I N-terminal propeptideType I N-terminal propeptideCox proportional hazards regression analysisProportional hazards regression analysisEarly-stage breast cancerPoor OS rateSerum P1NP levelsKaplan-Meier methodOverall survival rateHazards regression analysisLower overall survivalBone metastasis developmentBreast cancer metastasisBlood sample collectionN-terminal propeptideAdvanced diseaseOverall survivalOS ratesSerum P1NPEvaluation of circulating biomarkers of bone metastases in early-stage breast cancer.
Dean-Colomb W, Hess K, Young E, Gornet T, Handy B, Moulder S, Ibrahim N, Pusztai L, Booser D, Valero V, Hortobagyi G, Esteva F. Evaluation of circulating biomarkers of bone metastases in early-stage breast cancer. Journal Of Clinical Oncology 2012, 30: 10-10. DOI: 10.1200/jco.2012.30.30_suppl.10.Peer-Reviewed Original ResearchP1NP levelsBreast cancerStage IInterleukin-6Cox proportional hazards regression analysisStage IV breast cancerElecsys 2010Proportional hazards regression analysisKaplan-Meier methodTime of diagnosisHazards regression analysisWorse overall survivalBone metastasis developmentProcollagen type 1Breast cancer recurrenceRoche Elecsys 2010Advanced diseaseMetastatic diseaseOverall survivalBone metastasesClinical factorsSerum levelsSerum P1NPBone turnoverBiomarker levelsEvaluation of circulating biomarkers of bone metastasis in early-stage breast cancer.
Dean-Colomb W, Hess K, Young E, Gornet T, Handy B, Moulder S, Ibrahim N, Pusztai L, Booser D, Valero V, Hortobagyi G, Esteva F. Evaluation of circulating biomarkers of bone metastasis in early-stage breast cancer. Journal Of Clinical Oncology 2012, 30: 10613-10613. DOI: 10.1200/jco.2012.30.15_suppl.10613.Peer-Reviewed Original ResearchP1NP valuesInterleukin-6Breast cancerClinical factorsHazard ratioCox proportional hazards regression analysisCox proportional hazards regression modelElecsys 2010Proportional hazards regression analysisEarly-stage breast cancerProportional hazards regression modelsSerum P1NP levelsKaplan-Meier methodHazards regression analysisBone metastasis developmentHazards regression modelsProcollagen type 1Breast cancer recurrenceRoche Elecsys 2010Advanced diseaseP1NP levelsBone metastasesSerum levelsBone turnoverUnivariate analysis
2011
P4-16-02: Problems with Identifying Bone Metastasis-Specific Genes without Considering Biological Differences between ER-Positive and ER-Negative Breast Cancers.
Hayashi N, Iwamoto T, Qi Y, Niikura N, Santarpia L, Nakamura S, Hortobagyi G, Pusztai L, Symmans F, Ueno N. P4-16-02: Problems with Identifying Bone Metastasis-Specific Genes without Considering Biological Differences between ER-Positive and ER-Negative Breast Cancers. Cancer Research 2011, 71: p4-16-02-p4-16-02. DOI: 10.1158/0008-5472.sabcs11-p4-16-02.Peer-Reviewed Original ResearchER-negative breast cancerER-positive breast cancerMetastasis-specific genesBone metastasesER statusBreast cancerPrimary invasive breast cancer patientsInvasive breast cancer patientsCox proportional hazards modelER-negative breast cancer cell linesNon-bone metastasisFirst metastatic siteBreast cancer patientsProportional hazards modelBreast cancer cell linesSignificant differencesBiological differencesCancer cell linesMetastatic sitesER-positiveCancer patientsDifferent biological potentialsHazards modelPatientsMetastasisP2-12-06: Nomogram To Predict Subsequent Bone Metastasis in Patients with Non Metastatic Breast Carcinomas.
Lousquy R, Delpech Y, Rouzier R, Gligorov J, Hsu L, Barranger E, Pusztai L, Uzan S, Hortobagyi G, Coutant C, Ibrahim N. P2-12-06: Nomogram To Predict Subsequent Bone Metastasis in Patients with Non Metastatic Breast Carcinomas. Cancer Research 2011, 71: p2-12-06-p2-12-06. DOI: 10.1158/0008-5472.sabcs11-p2-12-06.Peer-Reviewed Original ResearchNon-metastatic breast cancerMetastatic breast cancerBreast cancerBone metastasesConcordance indexHigh riskCox proportional hazards regression modelNon-metastatic breast carcinomaMultivariate logistic regression analysisProportional hazards regression modelsM.D. Anderson Cancer CenterBreast cancer molecular subtypesMethods Medical recordsSubsequent bone metastasesLymph node statusLymphovascular space invasionSelection of patientsTime of diagnosisMetastatic breast carcinomaHazards regression modelsAnderson Cancer CenterCancer molecular subtypesLogistic regression analysisDesign of trialsAdjuvant hormonotherapy
2009
CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence
Andre F, Xia W, Conforti R, Wei Y, Boulet T, Tomasic G, Spielmann M, Zoubir M, Berrada N, Arriagada R, Hortobagyi GN, Hung M, Pusztai L, Delaloge S, Michiels S, Cristofanilli M. CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence. The Oncologist 2009, 14: 1182-1188. PMID: 19939894, DOI: 10.1634/theoncologist.2009-0161.Peer-Reviewed Original ResearchConceptsPrimary breast tumorsCXCR4 expressionBone metastasesBreast tumorsClinical characteristicsDistant metastasisPrognostic valueHigh riskLigand stromal cell-derived factor-1Stromal cell-derived factor-1Cell-derived factor-1Bone-targeted agentsEarly breast cancerProspective clinical trialsCox regression modelNovel adjuvant strategyExpression of CXCR4Chemokine receptor 4Early metastatic processOccurrence of metastasesSpecific organ sitesCXCR4 tumorsDistant recurrenceOverall survivalAdjuvant strategies