2023
Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleIn-home Visits and Subsequent Health Outcomes in Medicare Advantage Beneficiaries With Coronary Artery Disease, Diabetes, Hypertension, and Depression
Smolderen K, Heath K, Ameli O, Spencer D, Natwick T, Musich S, Miedico T, Mena-Hurtado C. In-home Visits and Subsequent Health Outcomes in Medicare Advantage Beneficiaries With Coronary Artery Disease, Diabetes, Hypertension, and Depression. Medical Care 2023, 61: 366-376. PMID: 37167558, DOI: 10.1097/mlr.0000000000001850.Peer-Reviewed Original ResearchConceptsPrimary care visitsCoronary artery diseaseMajor adverse cardiovascular eventsFirst primary care visitAdverse cardiovascular eventsCare visitsWait-list control groupHome visitsArtery diseaseList control groupControl groupCardiovascular eventsCare metricsOptum Labs Data WarehouseHigh-morbidity conditionsMedicare Advantage populationInpatient care episodesMedicare Advantage beneficiariesRetrospective data analysisSubsequent health outcomesIndex dateSecondary outcomesEmergency visitsPrimary outcomeInpatient stay
2022
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityCoronary Artery DiseaseDepressionHumansMalePeripheral Arterial DiseaseRisk FactorsConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesAssociation of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide
Harris KM, Mena-Hurtado C, Burg MM, Vriens PW, Heyligers J, Smolderen KG. Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide. Journal Of Vascular Surgery 2022, 77: 480-489. PMID: 36115521, DOI: 10.1016/j.jvs.2022.09.008.Peer-Reviewed Original ResearchConceptsLength of stayChronic limb-threatening ischemiaAnxiety disorder diagnosisAssociation of depressionRevascularization cohortMajor amputationDisorder diagnosisSurgical revascularizationEndovascular revascularizationHigher oddsLonger median LOSMedian LOSLonger LOSAnxiety disordersDocumentation of depressionPeripheral artery diseaseLimb-threatening ischemiaRisk of amputationNational Inpatient SamplePatients' sociodemographic dataHigher median costArtery diseaseIllness severityPsychiatric comorbidityComorbid depressionA Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment
Rome D, Sales A, Leeds R, Usseglio J, Cornelius T, Monk C, Smolderen KG, Moise N. A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment. Current Atherosclerosis Reports 2022, 24: 709-720. PMID: 35751731, PMCID: PMC9398966, DOI: 10.1007/s11883-022-01048-0.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCoronary DiseaseDepressionFemaleHumansMalePrevalenceRisk FactorsSex FactorsConceptsCoronary heart diseaseCardiovascular diseaseMechanism of actionHeart diseaseNarrative reviewManagement of depressionPrevalence of depressionRecent FindingsWomenCardiovascular outcomesAutonomic factorsDepression treatmentComorbid depressionTreatment inertiaGreater prevalenceTherapeutic targetPrevalenceStrong associationWomenDepressionDiseaseGreater mortalityTreatment effectsAssociationMenTreatment
2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean age
2018
Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System
Smolderen KG, Plomondon ME, Armstrong EJ, Hess E, Waldo S, Tsai TT, Maddox TM. Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System. Vascular Medicine 2018, 23: 454-460. PMID: 29801427, DOI: 10.1177/1358863x18770275.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedChi-Square DistributionComorbidityDepressionEndovascular ProceduresFemaleHumansHypertensionKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseaseProportional Hazards ModelsRetrospective StudiesRisk FactorsStrokeTime FactorsTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsNon-fatal cardiovascular eventsPeripheral vascular interventionsCardiovascular eventsDiagnosis of depressionHazard ratioMedical recordsAge-adjusted hazard ratioLong-term prognostic outcomesNon-fatal cardiovascular outcomesPeripheral endovascular interventionsLong-term outcomesPatients' medical recordsVA healthcare systemVeterans Affairs centersCause deathCardiovascular outcomesConsecutive patientsAdditional covariatesEndovascular interventionRecent diagnosisPrognostic outcomesDepressed patientsDisease outcomeVascular interventionsHigh risk
2017
Response by Smolderen et al to Letter Regarding Article, “Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction
Smolderen KGE, Gosch KG, Buchanan DM, Spertus JA. Response by Smolderen et al to Letter Regarding Article, “Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction. Circulation 2017, 136: 1355-1356. PMID: 28972066, PMCID: PMC9901181, DOI: 10.1161/circulationaha.117.030175.Peer-Reviewed Original ResearchDepression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction
Smolderen KG, Spertus JA, Gosch K, Dreyer RP, D'Onofrio G, Lichtman JH, Geda M, Beltrame J, Safdar B, Bueno H, Krumholz HM. Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction. Circulation 2017, 135: 1762-1764. PMID: 28461419, PMCID: PMC5755692, DOI: 10.1161/circulationaha.116.027042.Peer-Reviewed Original ResearchDepression Treatment and 1-Year Mortality After Acute Myocardial Infarction
Smolderen KG, Buchanan DM, Gosch K, Whooley M, Chan PS, Vaccarino V, Parashar S, Shah AJ, Ho PM, Spertus JA. Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction. Circulation 2017, 135: 1681-1689. PMID: 28209727, PMCID: PMC5796757, DOI: 10.1161/circulationaha.116.025140.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive AgentsCause of DeathDepressionFemaleHealth StatusHumansKaplan-Meier EstimateMaleMental HealthMiddle AgedMyocardial InfarctionProportional Hazards ModelsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRegistriesRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionPatient Health Questionnaire-9Untreated depressionMyocardial infarctionObservational multicenter cohort studyMulticenter cohort studyOne-year mortalityLong-term mortalityPrognosis of patientsPHQ-9 scoresTreatment of depressionPHQ-9 criteriaAMI severityPHQ scoresTRIUMPH studyCohort studyClinical factorsDepression treatmentDischarge diagnosisQuestionnaire-9Medical recordsAMI admissionsPatientsBetter outcomesMortality rate
2015
Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatients
2014
Peripheral arterial disease, gender, and depression in the Heart and Soul Study
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. Journal Of Vascular Surgery 2014, 60: 396-403. PMID: 24661811, PMCID: PMC4199228, DOI: 10.1016/j.jvs.2014.02.013.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRisk factorsArterial diseaseDevelopment of PADStable coronary artery diseaseGender-specific risk factorsNontraditional risk factorsProspective cohort studyWorse lipid profileHistory of smokingTraditional risk factorsCoronary artery diseaseStrongest independent factorRole of depressionLogistic regression modelsSoul StudyCohort studyInflammatory biomarkersArtery diseaseDiabetes mellitusElevated fibrinogenSimilar prevalenceLipid profileHigh prevalenceIndependent factors
2012
Type D Assessment in Patients With Chronic Heart Failure and Peripheral Arterial Disease: Evaluation of the Experimental DS(3) Scale Using Item Response Theory
Emons WH, Mols F, Pelle A, Smolderen KG, Denollet J. Type D Assessment in Patients With Chronic Heart Failure and Peripheral Arterial Disease: Evaluation of the Experimental DS(3) Scale Using Item Response Theory. Journal Of Personality Assessment 2012, 94: 210-219. PMID: 22339314, DOI: 10.1080/00223891.2011.645933.Peer-Reviewed Original Research
2011
Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Vaccarino V, Lichtman JH, Bekelman DB, Chan PS. Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry. Biological Psychiatry 2011, 71: 22-29. PMID: 21903199, PMCID: PMC3332544, DOI: 10.1016/j.biopsych.2011.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedBlood PlateletsCognition DisordersC-Reactive ProteinDepressionFemaleHealth Status DisparitiesHumansLeukocyte CountMaleMiddle AgedMyocardial InfarctionNatriuretic Peptide, BrainPeptide FragmentsPrognosisRegistriesRegression AnalysisRetrospective StudiesSurveys and QuestionnairesTranslational Research, BiomedicalYoung AdultConceptsCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsHs-CRPNT-proBNPWBC countAcute Myocardial Infarction Patients' Health Status (TRIUMPH) registryMyocardial infarction prognosisHs-CRP valuesLong-term outcomesAcute myocardial infarctionDepressive symptom domainsAMI prognosisIndex hospitalizationClinical characteristicsCoagulation markersAMI patientsMyocardial infarctionPlatelet levelsBiomarker levelsDepression scoresCertain biomarkersDepression dimensionSymptomsSomatic symptomsAccuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease
Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2011, 4: 533-540. PMID: 21862720, DOI: 10.1161/circoutcomes.110.960302.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationComorbidityCoronary DiseaseDepressionDepressive Disorder, MajorDiagnostic Tests, RoutineFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsPrognosisRiskSensitivity and SpecificitySurveys and QuestionnairesSurvival AnalysisUnited StatesConceptsCoronary heart diseaseAmerican Heart AssociationStable coronary heart diseasePatient Health QuestionnaireMajor depressive disorderHeart diseaseCardiovascular eventsPrognostic valueHeart AssociationDepressive disorderHealth QuestionnaireHigh-density lipoprotein levelsDepression screening protocolSubsequent cardiovascular eventsAdverse cardiovascular outcomesBody mass indexGold standard interviewCardiovascular outcomesIdentifies patientsHeart failureScreening methodLipoprotein levelsMass indexDepression screeningMyocardial infarctionPercutaneous transluminal angioplasty: Association between depressive symptoms and diminished health status benefits
Smolderen KG, Safley DM, House JA, Spertus JA, Marso SP. Percutaneous transluminal angioplasty: Association between depressive symptoms and diminished health status benefits. Vascular Medicine 2011, 16: 260-266. PMID: 21828173, DOI: 10.1177/1358863x11415568.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonCross-Sectional StudiesDepressionFemaleHealth StatusHumansLinear ModelsMaleMiddle AgedMissouriPatient SatisfactionPeripheral Arterial DiseaseProspective StudiesQuality of LifeRecovery of FunctionRegistriesRisk AssessmentRisk FactorsSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsPeripheral artery diseasePeripheral endovascular revascularizationPercutaneous transluminal angioplastyDepressive symptomsHealth statusWorsened depressionHealth status 1 yearDisease-specific health statusHealth status benefitsBaseline depressive symptomsHealth status outcomesEndovascular revascularizationPAD patientsTransluminal angioplastyArtery diseaseDepression statusCardiac diseasePatientsStatus outcomesSymptomsLess improvementDepressionBaselineStatus benefitsDiseaseReal-World Lessons From the Implementation of a Depression Screening Protocol in Acute Myocardial Infarction Patients
Smolderen KG, Buchanan DM, Amin AA, Gosch K, Nugent K, Riggs L, Seavey G, Spertus JA. Real-World Lessons From the Implementation of a Depression Screening Protocol in Acute Myocardial Infarction Patients. Circulation Cardiovascular Quality And Outcomes 2011, 4: 283-292. PMID: 21505152, PMCID: PMC3336360, DOI: 10.1161/circoutcomes.110.960013.Peer-Reviewed Original ResearchConceptsDepression screening protocolAcute myocardial infarction patientsPatient Health QuestionnaireMyocardial infarction patientsScreening protocolInfarction patientsPHQ-9AHA recommendationsAcute Myocardial Infarction RegistryAmerican Heart Association statementMyocardial Infarction RegistryCoronary artery diseaseAcute myocardial infarctionQuality improvement initiativesFull PHQ-9Implementation feedbackAHA statementCoronary patientsArtery diseaseMyocardial infarctionPHQ-2Provider suggestionsHealth QuestionnaireRegistry dataScreening program
2010
Letter by Smolderen and Pelle Regarding Article, “Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Cardiovascular Disease: A Randomized Trial”
Smolderen KG, Pelle AJ. Letter by Smolderen and Pelle Regarding Article, “Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Cardiovascular Disease: A Randomized Trial”. Circulation 2010, 122: e445; author reply e446. PMID: 20805437, DOI: 10.1161/circulationaha.110.942086.Peer-Reviewed Original ResearchYounger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater oddsType D personality mediates the relationship between remembered parenting and perceived health.
van den Broek KC, Smolderen KG, Pedersen SS, Denollet J. Type D personality mediates the relationship between remembered parenting and perceived health. Journal Of The Academy Of Consultation-Liaison Psychiatry 2010, 51: 216-24. PMID: 20484719, DOI: 10.1176/appi.psy.51.3.216.Peer-Reviewed Original ResearchConceptsType D personalityD personalityHealth outcomesShort Form Health SurveyRemembered parentingGeneral Dutch populationBeck Depression InventoryAdverse childhood experiencesAdverse outcomesHospital AnxietyCardiovascular diseaseHealth SurveyDepression ScaleDepression InventoryDutch populationRemembered RelationshipOutcomesChildhood experiencesType DParent scaleAssociationHealth