2023
Patient knowledge and preferences for peripheral artery disease treatment
Smolderen K, Romain G, Gosch K, Arham A, Provance J, Spertus J, Poosala A, Shishehbor M, Safley D, Scott K, Stone N, Mena-Hurtado C. Patient knowledge and preferences for peripheral artery disease treatment. Vascular Medicine 2023, 28: 397-403. PMID: 37638882, PMCID: PMC10591804, DOI: 10.1177/1358863x231181613.Peer-Reviewed Original ResearchPeripheral artery diseaseTreatment goalsPatient knowledgeTreatment optionsTreatment preferencesHeart attack/strokeSymptomatic peripheral artery diseasePeripheral artery disease treatmentImportant treatment goalQuality of lifeCost of treatmentSpecific treatment goalsMulticenter registryPAD symptomsPain reliefSecondary preventionArtery diseaseTreatment choiceTreatment benefitPatient understandingPatientsMedical decision makingDisease managementClaudicationDisease treatmentEfficacy of a web-based healthcare innovation to advance the quality of life and care of patients with an implantable cardioverter defibrillator (ACQUIRE-ICD): a randomized controlled trial
Skov O, Johansen J, Nielsen J, Larroudé C, Riahi S, Melchior T, Vinther M, Skovbakke S, Rottmann N, Wiil U, Brandt C, Smolderen K, Spertus J, Pedersen S. Efficacy of a web-based healthcare innovation to advance the quality of life and care of patients with an implantable cardioverter defibrillator (ACQUIRE-ICD): a randomized controlled trial. EP Europace 2023, 25: euad253. PMID: 38055845, PMCID: PMC10700011, DOI: 10.1093/europace/euad253.Peer-Reviewed Original ResearchConceptsWeb-based interventionUsual careDevice acceptanceFlorida Patient Acceptance SurveySymptoms of anxietyCare of patientsSymptoms of depressionQuality of lifeImplantable cardioverter defibrillatorImplantable cardioverter defibrillator patientsRandomized controlled trialsFirst-time ICD recipientsOnline patient forumsRemote device monitoringImplant centresPsychological interventionsHealthcare innovationAcceptability surveyStandard interventionGoal settingAnxiety symptomsPatient forumsCareInterventionNon-blinded
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageTreatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid
Smolderen KG, Pacheco C, Provance J, Stone N, Fuss C, Decker C, Bunte M, Jelani QU, Safley DM, Secemsky E, Sepucha KR, Spatz ES, Mena-Hurtado C, Spertus JA. Treatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid. Vascular Medicine 2021, 26: 273-280. PMID: 33627058, PMCID: PMC8169642, DOI: 10.1177/1358863x20988780.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseTreatment optionsSymptoms of claudicationInvasive treatment optionNon-invasive treatmentQuality of lifeClaudication symptomsClaudication treatmentPatient knowledgeSpecialty careTreatment decisionsDecision aidPatientsCliniciansDecisional needsInternational Patient Decision Aid Standards criteriaStandard criteriaPrototype decision aidImplementation logisticsSymptomsDecisional qualityDiseaseTreatmentClaudication
2020
Cilostazol and peripheral artery disease-specific health status in ambulatory patients with symptomatic PAD
Mohammed M, Gosch K, Safley D, Jelani QU, Aronow HD, Mena C, Shishehbor MH, Spertus JA, Abbott JD, Smolderen KG. Cilostazol and peripheral artery disease-specific health status in ambulatory patients with symptomatic PAD. International Journal Of Cardiology 2020, 316: 222-228. PMID: 32464249, DOI: 10.1016/j.ijcard.2020.05.042.Peer-Reviewed Original ResearchConceptsPeripheral Artery QuestionnaireHealth statusDisease-specific health statusPatient-reported health statusHeart failure historyNon-cilostazol groupUse of cilostazolPAQ scoresImprovement of symptomsSubsequent health statusQuality of lifeCilostazol therapyCilostazol useSymptomatic PADPatient characteristicsPharmacological optionsAmbulatory patientsLimitation scoresMean ageFunctional statusUS cohortTreatment goalsSummary scoresCilostazolPatientsLevel of disease and association with health status in patients presenting with claudication from the PORTRAIT registry
Vogel TR, Braet DJ, Kruse RL, Bath J, Wang J, Gosch K, Smolderen KG. Level of disease and association with health status in patients presenting with claudication from the PORTRAIT registry. Journal Of Vascular Surgery 2020, 72: 2017-2026. PMID: 32325227, DOI: 10.1016/j.jvs.2020.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleFunctional StatusHealth Status IndicatorsHumansIntermittent ClaudicationMaleMiddle AgedPatient SatisfactionPeripheral Arterial DiseasePredictive Value of TestsQuality of LifeRegistriesRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsPeripheral artery diseasePAQ summary scorePeripheral Artery QuestionnaireQuality of lifeAnkle-brachial indexMultilevel diseaseAortoiliac diseaseHealth statusAnatomic levelSummary scoresMedical managementHigh ankle-brachial indexFemoral-popliteal diseaseTreatment of aortoiliacChronic kidney diseaseHistory of diabetesPAQ scoresPeripheral arterial diseaseOverall health statusSimilar health statusHealth status informationStudent's t-testLevel of diseaseRepeated-measures analysisInfrapopliteal disease
2019
Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status
Johnston AL, Vemulapalli S, Gosch KL, Aronow HD, Abbott JD, Patel MR, Smolderen KG, Shishebor M, Spertus JA, Jones WS. Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status. Journal Of Vascular Surgery 2019, 69: 906-912. PMID: 30626552, DOI: 10.1016/j.jvs.2018.07.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaCost of IllnessFemaleHealth StatusHemodynamicsHumansIntermittent ClaudicationMaleMiddle AgedNetherlandsPatient Reported Outcome MeasuresPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexUnited StatesConceptsAnkle-brachial indexPeripheral artery diseasePeripheral Artery QuestionnaireIntermittent claudicationRutherford classificationABI valuesPAQ scoresArtery diseaseImpact of PADHealth statusMean ankle-brachial indexPAD-specific health statusSevere peripheral artery diseasePAQ summary scoreStudy of patientsQuality of lifeHealth status assessmentRutherford classNew onsetPatient's symptomsHemodynamic assessmentLife scoresFunctional statusPatients' perceptionsInternational cohort
2018
Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry
Hammad TA, Smolderen KG, Spertus JA, Jones PG, Shishehbor MH. Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry. Vascular Medicine 2018, 24: 32-40. PMID: 29992849, DOI: 10.1177/1358863x18785026.Peer-Reviewed Original ResearchConceptsPain-free walking distancePeripheral artery diseaseMaximum walking distancePeripheral Artery QuestionnairePhysical limitation scoreWalking distancePatient factorsLimitation scoresImpact of PADAnkle-brachial index (ABI) testExercise ankle-brachial indexOnset of claudicationPost-exercise ABIAnkle-brachial indexQuality of lifeHierarchical logistic regression modelsLogistic regression modelsPORTRAIT registryArtery diseasePatient's symptomsPatient functioningABI testingSummary scoresHealth statusSymptomsEffectiveness of a comprehensive interactive eHealth intervention on patient-reported and clinical outcomes in patients with an implantable cardioverter defibrillator [ACQUIRE-ICD trial]: study protocol of a national Danish randomised controlled trial
Pedersen SS, Skovbakke SJ, Wiil UK, Schmidt T, dePont Christensen R, Brandt CJ, Sørensen J, Vinther M, Larroudé CE, Melchior TM, Riahi S, Smolderen KGE, Spertus JA, Johansen JB, Nielsen JC. Effectiveness of a comprehensive interactive eHealth intervention on patient-reported and clinical outcomes in patients with an implantable cardioverter defibrillator [ACQUIRE-ICD trial]: study protocol of a national Danish randomised controlled trial. BMC Cardiovascular Disorders 2018, 18: 136. PMID: 29969990, PMCID: PMC6029360, DOI: 10.1186/s12872-018-0872-7.Peer-Reviewed Original ResearchMeSH KeywordsDefibrillators, ImplantableDenmarkElectric CountershockHealth StatusHeart FailureHumansMental HealthMulticenter Studies as TopicPatient Reported Outcome MeasuresPredictive Value of TestsProspective StudiesQuality of LifeRandomized Controlled Trials as TopicRemote Sensing TechnologyRisk FactorsTelemedicineTelemetryTime FactorsTreatment OutcomeConceptsImplantable cardioverter defibrillatorQuality of lifeEHealth interventionsUsual careClinical outcomesCardioverter defibrillatorFlorida Patient Acceptance SurveyCardiac synchronization therapyFirst ICD therapyTrial registrationThe trialCare innovationsManagement of patientsPatient-reported outcomesFirst‐time implantable cardioverter defibrillatorsMonitoring of symptomsQuality of carePatient-physician interactionFirst hospitalisationICD therapyPrimary endpointSecondary endpointsMore patientsSuperiority trialDisease management approachClinical effectivenessPORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional statusAssociation between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry
Noyes AM, Abbott JD, Gosch K, Smolderen K, Spertus JA, Hyder O, Soukas P, Shishehbor MH, Aronow HD. Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry. Vascular Medicine 2018, 23: 32-38. PMID: 29338591, DOI: 10.1177/1358863x17747047.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePoor health statusIntermittent claudicationHealth statusPatient characteristicsDisease-specific health status measuresNon-vascular factorsPeripheral arterial diseaseChronic lung diseaseSpecialty care visitsTime of presentationHealth status measuresMultivariable linear regressionPatients' health statusQuality of lifeCare visitsArtery diseaseInitial presentationArterial diseaseBack painExercise programTreatment disparitiesLung diseaseFemale sexFunctional status
2017
Preinfarct Health Status and the Use of Early Invasive Versus Ischemia-Guided Management in Non–ST-Elevation Acute Coronary Syndrome
Qintar M, Smolderen KG, Chan PS, Gosch KL, Jones PG, Buchanan DM, Girotra S, Spertus JA. Preinfarct Health Status and the Use of Early Invasive Versus Ischemia-Guided Management in Non–ST-Elevation Acute Coronary Syndrome. The American Journal Of Cardiology 2017, 120: 1062-1069. PMID: 28797471, PMCID: PMC5766265, DOI: 10.1016/j.amjcard.2017.06.045.Peer-Reviewed Original ResearchConceptsEarly invasive managementEarly invasive treatmentInvasive managementHealth statusMyocardial infarctionInvasive treatmentAcute Myocardial Infarction Patients' Health StatusAcute Coronary Events (GRACE) risk scoreElevation acute coronary syndromeProspective Registry Evaluating OutcomesHighest risk decileHospital treatment strategiesPoor baseline qualityAcute coronary syndromeElevation myocardial infarctionWorse health statusHigher mortality riskPatients' health statusQuality of lifeAngina frequencyNSTEMI cohortCoronary syndromeGRACE scoreMulticenter registryNon–STA Personalized and Interactive Web-Based Health Care Innovation to Advance the Quality of Life and Care of Patients With Heart Failure (ACQUIRE-HF): A Mixed Methods Feasibility Study
Pedersen SS, Schmidt T, Skovbakke SJ, Wiil UK, Egstrup K, Smolderen KG, Spertus JA. A Personalized and Interactive Web-Based Health Care Innovation to Advance the Quality of Life and Care of Patients With Heart Failure (ACQUIRE-HF): A Mixed Methods Feasibility Study. JMIR Research Protocols 2017, 6: e96. PMID: 28536092, PMCID: PMC5461421, DOI: 10.2196/resprot.7110.Peer-Reviewed Original ResearchKansas City Cardiomyopathy QuestionnaireHeart failureHealth statusNursing staffLeft ventricular ejection fractionPatient-reported health statusOutpatient HF clinicOwn disease managementMixed methods feasibility studyMajority of patientsSubset of patientsVentricular ejection fractionOdense University HospitalCare of patientsSelf-care behaviorsMethods feasibility studyDisease-specific measuresPatient-centered toolsQuality of lifeHF clinicEjection fractionPre-post designOutpatient clinicUniversity HospitalExperienced deterioration
2015
A personalized and interactive web-based innovation to AdvanCe the QualIty of life and caRE in Heart Failure patients (ACQUIRE-HF)
Pedersen S, Petersen A, Møller J, Zwisler A, Sørensen J, Pedersen C, Wiil U, Smolderen K, Spertus J. A personalized and interactive web-based innovation to AdvanCe the QualIty of life and caRE in Heart Failure patients (ACQUIRE-HF). International Journal Of Integrated Care 2015, 15 DOI: 10.5334/ijic.2281.Peer-Reviewed Original ResearchGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control