2023
Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method
Ngufor C, Yao X, Inselman J, Ross J, Dhruva S, Graham D, Lee J, Siontis K, Desai N, Polley E, Shah N, Noseworthy P, MN; New Haven C. Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method. American Heart Journal 2023, 260: 124-140. PMID: 36893934, PMCID: PMC10615250, DOI: 10.1016/j.ahj.2023.02.015.Peer-Reviewed Original ResearchConceptsOral anticoagulantsAtrial fibrillationPatient subgroupsComposite outcomeIschemic strokeEffect of OACsLifelong oral anticoagulationNonvitamin K antagonistNew oral anticoagulantsNonvalvular atrial fibrillationPrimary composite outcomeGlomerular filtration rateFuture prospective studiesOptumLabs Data WarehousePopulation-level effectivenessOAC useOral anticoagulationVASc scoreCause mortalityK antagonistsPrimary endpointWarfarin usersRenal functionAF patientsEntire cohort
2021
Feasibility of using real-world data in the evaluation of cardiac ablation catheters: a test-case of the National Evaluation System for Health Technology Coordinating Center
Dhruva SS, Jiang G, Doshi AA, Friedman DJ, Brandt E, Chen J, Akar JG, Ross JS, Ervin KR, Farr K, Shah ND, Coplan P, Noseworthy PA, Zhang S, Forsyth T, Schulz WL, Yu Y, Drozda JP. Feasibility of using real-world data in the evaluation of cardiac ablation catheters: a test-case of the National Evaluation System for Health Technology Coordinating Center. BMJ Surgery Interventions & Health Technologies 2021, 3: e000089. PMID: 35047806, PMCID: PMC8749235, DOI: 10.1136/bmjsit-2021-000089.Peer-Reviewed Original ResearchPositive predictive valuePersistent atrial fibrillationIschemic ventricular tachycardiaAblation catheterHealth systemAtrial fibrillationVentricular tachycardiaCardiac ablation catheterAcute heart failureDuration of patientsHealth system dataCardiac tamponadeIschemic strokeRetrospective cohortHeart failureClinical outcomesEndpoint ascertainmentPredictive valueCatheterChart validationCoordinating CenterTachycardiaPatientsFibrillationParticipant population
2014
National trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010
Wang Y, Lichtman JH, Dharmarajan K, Masoudi FA, Ross JS, Dodson JA, Chen J, Spertus JA, Chaudhry SI, Nallamothu BK, Krumholz HM. National trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010. American Heart Journal 2014, 169: 78-85.e4. PMID: 25497251, PMCID: PMC4824179, DOI: 10.1016/j.ahj.2014.06.011.Peer-Reviewed Original Research
2012
The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration
Keyhani S, Arling G, Williams LS, Ross JS, Ordin DL, Myers J, Tyndall G, Vogel B, Bravata DM. The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration. Medical Care 2012, 50: 66-73. PMID: 22182924, DOI: 10.1097/mlr.0b013e3182294092.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overBrain IschemiaFemaleFibrinolytic AgentsHealth Services MisuseHealth Status IndicatorsHumansMaleMiddle AgedRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorUnited StatesUnited States Department of Veterans AffairsConceptsVHA medical centersTissue plasminogen activatorVeterans Health AdministrationAcute ischemic strokeEligible patientsStroke patientsIschemic strokeSymptom onsetThrombolytic therapyHealth AdministrationStroke symptom onsetAcute stroke patientsIschemic stroke patientsEligible stroke patientsMedical record reviewLow annual volumeThrombolysis deliveryRecord reviewWrong doseVHA systemClinical conditionsMedical CenterEligible veteransEligibility criteriaPatients
2011
Estimating and Reporting on the Quality of Inpatient Stroke Care by Veterans Health Administration Medical Centers
Arling G, Reeves M, Ross J, Williams LS, Keyhani S, Chumbler N, Phipps MS, Roumie C, Myers LJ, Salanitro AH, Ordin DL, Myers J, Bravata DM. Estimating and Reporting on the Quality of Inpatient Stroke Care by Veterans Health Administration Medical Centers. Circulation Cardiovascular Quality And Outcomes 2011, 5: 44-51. PMID: 22147888, PMCID: PMC3261327, DOI: 10.1161/circoutcomes.111.961474.Peer-Reviewed Original ResearchConceptsVeterans Health Administration medical centersStroke care qualityEligible patientsMedical CenterInpatient stroke care qualityDeep vein thrombosis prophylaxisEvidence-based quality indicatorsCare qualityInpatient stroke carePressure ulcer risk assessmentUlcer risk assessmentStudy patientsThrombosis prophylaxisEarly ambulationIschemic strokeLipid managementRetrospective cohortDysphagia screeningStroke careMedian numberPatientsFiscal year 2007Interfacility variationQuality indicatorsQI ratesPrevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization
Roumie CL, Ofner S, Ross JS, Arling G, Williams LS, Ordin DL, Bravata DM. Prevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization. Circulation Cardiovascular Quality And Outcomes 2011, 4: 399-407. PMID: 21693725, PMCID: PMC3140571, DOI: 10.1161/circoutcomes.110.959809.Peer-Reviewed Original ResearchConceptsBP controlBlood pressureIschemic strokeStroke patientsLower oddsAcute ischemic stroke hospitalizationsInadequate blood pressure controlHistory of hypertensionPercent of patientsBlood pressure controlElevated blood pressureSystolic blood pressureIschemic stroke hospitalizationsYears of ageHypertension careHypertension historyDischarge dispositionStroke eventsIndex eventStroke hospitalizationsBlack raceBP valuesCardiovascular diseaseNational guidelinesPatients