2023
The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesCell SurvivalHumansKidneyLupus NephritisSodiumSodium-Potassium-Exchanging ATPaseConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase
2021
Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition
Chernova I, Craft J. Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition. Cell Reports Medicine 2021, 2: 100479. PMID: 35028618, PMCID: PMC8714907, DOI: 10.1016/j.xcrm.2021.100479.Peer-Reviewed Original Research
2020
Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesHypoxiaKidneyLupus Erythematosus, SystemicLupus NephritisMiceConceptsHypoxia-inducible factor-1Lupus nephritisT cellsTissue hypoxiaT-cell-mediated injuryCell-mediated injuryHIF-1 blockadeKidney tissue hypoxiaSystemic lupus erythematosusHuman lupus nephritisMurine lupus nephritisRenal injuryAutoimmune injuryLupus erythematosusAutoimmune diseasesImmune cellsRenal tissueMurine modelTissue damageMore hypoxicNephritisInjuryLow oxygen tensionOxygen tensionFactor 1
2015
Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 2015, 42: 552-565. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutoantibodiesCD11c AntigenCell DifferentiationFemaleGene Expression RegulationHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinKidneyLungLupus NephritisMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionT-Lymphocytes, Helper-InducerConceptsInducible T-cell costimulatorOrgan inflammationICOS ligandFollicular helper cell differentiationLupus-prone MRLT-cell costimulatorHelper cell differentiationLupus pathologyLung inflammationAutoantibody formationAutoantibody productionMurine lupusInflamed organsLymphoid tissueT cellsB cellsPathogenic relevanceInflammationLupusPI3K-AktSelective ablationCell differentiationNonredundant rolePotent promoterCells
2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogation
2004
The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression
Kong PL, Morel L, Croker BP, Craft J. The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression. The Journal Of Immunology 2004, 172: 2785-2794. PMID: 14978078, DOI: 10.4049/jimmunol.172.5.2785.Peer-Reviewed Original ResearchConceptsMRL/Prototypic systemic autoimmune diseaseDouble-negative T cellsAutoimmune disease expressionEtiology of lupusResistant C57BL/6 backgroundLupus-prone miceSystemic autoimmune diseaseFas-deficient miceT cell activationLupus susceptibility lociAutoantibody productionAutoimmune diseasesKidney diseaseT cellsMRL miceAbsence of Fas
2003
Role of the H‐2 haplotype in Fas‐intact lupus‐prone MRL mice: association with autoantibodies but not renal disease
Kong PL, Zhu T, Madaio MP, Craft J. Role of the H‐2 haplotype in Fas‐intact lupus‐prone MRL mice: association with autoantibodies but not renal disease. Arthritis & Rheumatism 2003, 48: 2992-2995. PMID: 14558109, DOI: 10.1002/art.11308.Peer-Reviewed Original ResearchCD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays
1998
Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation.
Fatenejad S, Peng SL, Disorbo O, Craft J. Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation. The Journal Of Immunology 1998, 161: 6427-32. PMID: 9834135, DOI: 10.4049/jimmunol.161.11.6427.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisAutoimmune DiseasesCell LineClonal DeletionColumbidaeCytochrome c GroupDown-RegulationFas ReceptorGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorImmune ToleranceLupus NephritisLymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicMolecular Sequence DataMutationPeptidesReceptors, Antigen, T-Cell, alpha-betaThymus GlandT-Lymphocyte SubsetsConceptsMRL/MpJ miceLupus-prone miceT cell toleranceCentral T cell toleranceT cellsLpr mutationCell toleranceSystemic autoimmune diseaseT cell autoreactivityAutoreactive T cellsB cell helpIntrathymic negative selectionMHC class IIMRL/MpJPeripheral control mechanismsAutoimmune backgroundThymic deletionIntrathymic deletionAutoimmune diseasesNonautoimmune miceCell helpTCR transgeneNonautoimmune strainsPeptide AgImmature CD4Perforin protects against autoimmunity in lupus-prone mice.
Peng S, Moslehi J, Robert M, Craft J. Perforin protects against autoimmunity in lupus-prone mice. The Journal Of Immunology 1998, 160: 652-60. PMID: 9551899, DOI: 10.4049/jimmunol.160.2.652.Peer-Reviewed Original ResearchConceptsLupus-prone miceAutoantibody productionImmune complex renal diseaseLupus-prone animalsPerforin-mediated cytotoxicityEnd-organ diseaseComplex renal diseaseAccelerated autoimmunityRenal diseaseLpr miceImmune homeostasisSystemic autoimmunityT cellsImmune systemAbnormal accumulationLpr animalsAutoimmunityFas AgMiceHypergammaglobulinemiaPerforinDiseaseAnimalsSpecific mechanismsRegulatory mechanisms
1996
Murine lupus in the absence of alpha beta T cells.
Peng SL, Madaio MP, Hughes DP, Crispe IN, Owen MJ, Wen L, Hayday AC, Craft J. Murine lupus in the absence of alpha beta T cells. The Journal Of Immunology 1996, 156: 4041-9. PMID: 8621947, DOI: 10.4049/jimmunol.156.10.4041.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsT cell-dependent mechanismBeta T cellsCell-dependent mechanismT cellsMurine lupusHuman systemic lupus erythematosusLupus-prone MRL miceSystemic lupus erythematosusSystemic autoimmune diseaseLupus erythematosusAutoimmune diseasesImmune depositsMRL miceAlpha betaLupusDiseaseMiceCellsErythematosusHypergammaglobulinemiaAutoantibodiesCD4AutoimmunityKidney