Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review
Nevius E, Gomes AC, Pereira JP. Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review. Clinical Reviews In Allergy & Immunology 2015, 51: 59-78. PMID: 26511861, PMCID: PMC5785098, DOI: 10.1007/s12016-015-8520-9.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisOsteoclast differentiationInflammatory cytokinesT lymphocytesOsteoclast precursorsChronic inflammatory autoimmune diseaseMultiple myeloid cellsInflammatory autoimmune diseaseChronic inflammatory diseaseInflammatory cellular infiltrationAdaptive immune responsesKey inflammatory cytokinesInflammatory cell migrationBone-resorbing osteoclastsIL-17Bone erosionAutoimmune diseasesAntibody responseBone resorptionInflammatory diseasesInnate signalsIL-1Immune responseArticular sitesCellular infiltrationOxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. Journal Of Experimental Medicine 2015, 212: 1931-1946. PMID: 26438360, PMCID: PMC4612084, DOI: 10.1084/jem.20150088.Peer-Reviewed Original ResearchConceptsOC precursorsBone surfaceEstrogen deficiency-induced osteoporosisBone mass homeostasisCell-cell interactionsTime-lapse microscopyBone metastatic cancerSignificant therapeutic potentialOxysterol ligandsFemale miceMale miceBone massMetastatic cancerLarge osteoclastsEBI2Nonhematopoietic cellsNovel pathwayTherapeutic potentialOsteoclastsTwo-photon microscopyMiceOsteoblastsVivoCellsOsteoporosis