2023
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, Müschen M, Choi J, Pereira J. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. ELife 2023, 12: e83533. PMID: 36912771, PMCID: PMC10042536, DOI: 10.7554/elife.83533.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsLymphotoxin beta receptorLeukemic cellsBeta receptorsLeukemic cell growthBone marrow microenvironmentStem cellsTransplant recipientsAML cellsMyeloblastic leukemiaMouse modelBone marrowLeukemia growthLymphotoxin α1β2Marrow microenvironmentPharmacological disruptionLymphopoiesisReceptorsHematopoietic outputMolecular mechanismsErythropoiesisDNA damage response pathwayCell growthCellsPhysiological mechanisms
2017
Chapter Two A Chemoattractant-Guided Walk Through Lymphopoiesis From Hematopoietic Stem Cells to Mature B Lymphocytes
Lim VY, Zehentmeier S, Fistonich C, Pereira JP. Chapter Two A Chemoattractant-Guided Walk Through Lymphopoiesis From Hematopoietic Stem Cells to Mature B Lymphocytes. Advances In Immunology 2017, 134: 47-88. PMID: 28413023, PMCID: PMC5784265, DOI: 10.1016/bs.ai.2017.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationChemokinesHematopoietic Stem CellsHumansLymphopoiesisConceptsHematopoietic stem cellsBone marrow parenchymaProgenitor cellsCell motility machinerySpecialized bone marrow nichesMarrow parenchymaStem cellsMultipotent progenitor cellsCommon lymphoid progenitor cellsStem/progenitor cellsBone marrow nicheBone marrow sinusoidsMotility machineryMature B cell poolStem cell factorLymphoid progenitor cellsEndothelial cellsMature B lymphocytesBCR signalingInterleukin-7Multilineage differentiationMarrow nicheHematopoietic cellsCell factorMarrow sinusoids