2024
Development of a Novel Intraperitoneal Icodextrin/Dextrose Solution for Enhanced Sodium Removal
Asher J, Ivey-Miranda J, Maulion C, Cox Z, Borges-Vela J, Mendoza-Zavala G, Cigarroa-Lopez J, Silva-Rueda R, Revilla-Monsalve C, Moreno-Villagomez J, Ramos-Mastache D, Goedje O, Crosbie I, McIntyre C, Finkelstein F, Turner J, Testani J, Rao V. Development of a Novel Intraperitoneal Icodextrin/Dextrose Solution for Enhanced Sodium Removal. Kidney Medicine 2024, 100938. DOI: 10.1016/j.xkme.2024.100938.Peer-Reviewed Original ResearchPD solutionsPeritoneal dialysisSodium removalIcodextrin PD solutionExposure of miceLong-term safetyClearance of uremic toxinsChronic therapyEdematous disordersStructural tissue changesAdverse eventsRemoval therapyEfficacy resultsHeart failureEvaluate safetyNet ultrafiltrationUremic toxin clearanceAnimal modelsIcodextrinKidney failureUremic toxinsTissue changesAscending concentrationsEfficient ultrafiltrationEfficacy
2020
First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2018
Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution
Mahoney D, Rao V, Asher J, Struyk G, Boutagy N, Feher A, Turner J, Sinusas A, Testani J. Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution. Journal Of Cardiac Failure 2018, 24: s34. DOI: 10.1016/j.cardfail.2018.07.099.Peer-Reviewed Original ResearchPeritoneal dialysisIntraperitoneal volumeHeart failureHour dwellFluid removalPlasma volumeNon-renal routesPeritoneal fluid samplesSodium removalMinutes dwell timeSolute dragIndicator dilution techniquePD catheterSerial plasmaSerum sodiumArterial accessDwell timeFluid instillationAnesthetized pigsRemoval solutionPeritoneal solutionsSurgical implantationGrams of sodiumFluid volumeLonger dwell times
2016
We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function
Turner JM. We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function. Seminars In Dialysis 2016, 29: 265-267. PMID: 27061273, DOI: 10.1111/sdi.12488.Commentaries, Editorials and LettersConceptsResidual renal functionPeritoneal dialysisRAAS inhibitorsRenal functionAngiotensin receptor blockersGlomerular filtration rateRAAS blockadeAldosterone systemReceptor blockersNephrotoxic agentsPD patientsPD populationFiltration rateModality failureUltrafiltration failureEnzyme inhibitorsPatientsPeritoneal membraneMorphologic changesInhibitorsMortalityCliniciansAnuriaAngiotensinFailure