2011
Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
Szepietowska B, Zhu W, Chan O, Horblitt A, Dziura J, Sherwin RS. Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia. Diabetes 2011, 60: 3154-3158. PMID: 22013013, PMCID: PMC3219955, DOI: 10.2337/db11-0432.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-AntagonistsAnimalsBlood GlucoseEpinephrineEthanolaminesFormoterol FumarateGlucagonGlucose Clamp TechniqueHypoglycemiaImidazolesInsulinMaleNorepinephrinePropanolaminesRatsRats, Sprague-DawleyReceptors, Adrenergic, betaVentromedial Hypothalamic NucleusConceptsCounterregulatory responsesVentromedial hypothalamusGlucose counterregulationAwake male Sprague-Dawley ratsB2AR agonistMale Sprague-Dawley ratsCounterregulatory hormone releaseDefective glucose counterregulationExogenous glucose requirementsHyperinsulinemic-hypoglycemic clamp studySprague-Dawley ratsLocal catecholamine releaseArtificial extracellular fluidΒ-Adrenergic ReceptorsEpinephrine responseGlucagon responseDiabetic patientsEpinephrine releaseSimilar insulinCatecholamine releaseHormone releaseGuide cannulaeClamp studiesTherapeutic benefitHypoglycemia
2010
Early Pharmacokinetic and Pharmacodynamic Effects of Mixing Lispro With Glargine Insulin Results of glucose clamp studies in youth with type 1 diabetes
Cengiz E, Tamborlane WV, Martin-Fredericksen M, Dziura J, Weinzimer SA. Early Pharmacokinetic and Pharmacodynamic Effects of Mixing Lispro With Glargine Insulin Results of glucose clamp studies in youth with type 1 diabetes. Diabetes Care 2010, 33: 1009-1012. PMID: 20150302, PMCID: PMC2858163, DOI: 10.2337/dc09-2118.Peer-Reviewed Original ResearchConceptsType 1 diabetesGlucose clamp studiesGlucose excursionsClamp studiesMeal-related glucose excursionsRapid-acting insulin analoguesRapid-acting insulinEuglycemic glucose clampTime-action curvePharmacodynamic peakA1c levelsTreatment burdenPharmacodynamic effectsDaily injectionsUnits/Pharmacodynamic actionClinical studiesGlucose clampMixed injectionGlargineEarly pharmacokineticsInsulin analoguesObjective clinicianInsulin pharmacokineticsLispro
2009
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia. Diabetes 2009, 58: 1237-1244. PMID: 19223595, PMCID: PMC2671041, DOI: 10.2337/db08-1557.Peer-Reviewed Original ResearchConceptsType 1 diabetic subjectsMedium-chain triglyceridesSynaptic transmissionDiabetic subjectsMedium-chain triglyceride ingestionType 1 diabetic patientsRat hippocampal slice preparationHippocampal synaptic transmissionBeta-hydroxybutyrate levelsType 1 diabetesHypoglycemic clamp studiesHippocampal slice preparationControl glucose concentrationsTriglyceride ingestionDiabetic patientsFatty acidsAcute hypoglycemiaSymptomatic responseHippocampal slicesSlice preparationFree fatty acidsGlucose levelsClamp studiesTherapeutic advantageNeuronal activity
2008
Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy
Swan KL, Dziura JD, Steil GM, Voskanyan GR, Sikes KA, Steffen AT, Martin ML, Tamborlane WV, Weinzimer SA. Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy. Diabetes Care 2008, 32: 240-244. PMID: 19017777, PMCID: PMC2628686, DOI: 10.2337/dc08-0595.Peer-Reviewed Original ResearchConceptsInsulin pump therapyGlucose infusion rateType 1 diabetesDay 1Day 4Pump therapyInsulin aspartPharmacodynamic parametersInsulin actionInsulin bolusRapid acting analogsEuglycemic clamp procedureExogenous glucose infusionGIR curveEffect of agePharmacodynamic measuresPharmacodynamic characteristicsClamp procedureInfusion siteGlucose infusionInfusion rateInsulin analoguesType 1AspartOverall insulin action
2007
Effect of Puberty on the Pharmacodynamic and Pharmacokinetic Properties of Insulin Pump Therapy in Youth With Type 1 Diabetes
Swan KL, Weinzimer SA, Dziura JD, Steil GM, Voskanyan GR, Steffen AT, Martin ML, Tamborlane WV. Effect of Puberty on the Pharmacodynamic and Pharmacokinetic Properties of Insulin Pump Therapy in Youth With Type 1 Diabetes. Diabetes Care 2007, 31: 44-46. PMID: 17909083, DOI: 10.2337/dc07-0737.Peer-Reviewed Original Research
2005
The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning
Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S. The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3731-3737. PMID: 15797955, DOI: 10.1210/jc.2004-2305.Peer-Reviewed Original ResearchConceptsInsulin sensitivityVisceral fatLipid depositionObese insulin-resistant adolescentsObese insulin-sensitive subjectsNormal glucose tolerancePeripheral insulin sensitivityIntramyocellular lipid contentBody mass indexInsulin-sensitive subjectsHyperinsulinemic-euglycemic clampInsulin-resistant adolescentsInsulin-sensitive controlsWide interindividual variationLipid partitioningLower lipid depositionPercent body fatMagnetic resonance imagingImportance of adiponectinObese insulinObese groupGlucose toleranceMass indexObese adolescentsIntramyocellular lipids
2004
Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2003
Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation
Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S. Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2014-2018. PMID: 12727947, DOI: 10.1210/jc.2002-021711.Peer-Reviewed Original ResearchConceptsAdiponectin levelsInsulin sensitivityAdolescent obesityObese adolescentsPutative modulatory effectsLower adiponectin levelsAbdominal fat distributionIntramyocellular lipid contentPlasma adiponectin levelsIntramyocellular lipid accumulationEuglycemic hyperinsulinemic clampTotal body fatMagnetic resonance imagingCentral adiposityPediatric populationInsulin resistanceIntramuscular lipid contentTriglyceride levelsFat distributionLipid contentPlasma triglyceridesFree fatty acidsBody fatModulatory effectsAdiponectin