2019
Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults
Park H, Shin M, Kim M, Bilsborrow J, Mohanty S, Montgomery R, Shaw A, Yoo S, Kang I. Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults. The Journal Of Immunology 2019, 202: 181.22-181.22. DOI: 10.4049/jimmunol.202.supp.181.22.Peer-Reviewed Original ResearchPeripheral blood cellsPeripheral blood mononuclear cellsInfluenza vaccine responsesT cellsEM CD8Memory CD8Vaccine responsesOlder adultsBlood cellsSignature genesEffector memory CD8Blood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Expression profilesSignificant associationTranscription factorsWhole bloodTranscriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profiles
2013
Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083)
Shin M, Kang Y, Lee N, Kim S, Kang K, Lazova R, Kang I. Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083). The Journal Of Immunology 2013, 190: 127.13-127.13. DOI: 10.4049/jimmunol.190.supp.127.13.Peer-Reviewed Original ResearchIL-1β productionAnti-dsDNA antibodiesIL-1βHuman monocytesReactive oxygen speciesCell responsesIL-1β dependent mannerPro-inflammatory cytokines IL-1βPeripheral blood mononuclear cellsSelf-nuclear antigensIL-17 productionSystemic lupus erythematosusInnate immune cellsBlood mononuclear cellsPathogenesis of lupusAntibody-positive seraCytokines IL-1βLupus pathogenesisLupus patientsLupus erythematosusAutoimmune responseCutaneous lesionsMononuclear cellsImmune cellsNLRP3 inflammasome
2012
Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1)
Kim H, Cho B, Sim J, Kim H, Yoo W, Kang I, Lee E. Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1). The Journal Of Immunology 2012, 188: 69.1-69.1. DOI: 10.4049/jimmunol.188.supp.69.1.Peer-Reviewed Original ResearchRheumatoid arthritisT cellsEM CD8Synovial fluidRA patientsMemory CD8Peripheral bloodMononuclear cellsHealthy controlsIL-10-producing CD8IL-4-producing CD8Synovial fluid mononuclear cellsProgression of RAPeripheral blood mononuclear cellsFluid mononuclear cellsEffector memory CD8T cell subsetsBlood mononuclear cellsKi-67 stainingDisease activitySuppressor cellsPD-1IL-15Cell subsetsLess perforin
2009
Alterations in the Kinetics of CD4+ T Cell Responses with Aging
Hong M, Dan J, Lee W, Kang I. Alterations in the Kinetics of CD4+ T Cell Responses with Aging. Journal Of Rheumatic Diseases 2009, 16: 271-280. DOI: 10.4078/jkra.2009.16.4.271.Peer-Reviewed Original ResearchKinetics of CD4T cell proliferationHr of stimulationT cell activationT cellsCD40L expressionCell proliferationCell activationPeripheral blood mononuclear cellsT cell immunityT cell responsesAnti-CD28 antibodiesBlood mononuclear cellsActivation marker CD69Duration of stimulationRisk of infectionT cell receptor stimulationAge-associated changesCell receptor stimulationYounger patientsCell immunityCD25 expressionMononuclear cellsElderly subjectsCD4