2015
IL-7Ralow memory CD8+ T cells are clonally anergic cells and defect in aerobic glycolysis pathway (HUM4P.274)
Sim J, Kim J, Seol M, Lee S, Cho B, Ko Y, Oh K, Lee D, Kim J, Park A, Kang I, Choi K, Kim H. IL-7Ralow memory CD8+ T cells are clonally anergic cells and defect in aerobic glycolysis pathway (HUM4P.274). The Journal Of Immunology 2015, 194: 122.5-122.5. DOI: 10.4049/jimmunol.194.supp.122.5.Peer-Reviewed Original ResearchMemory CD8T cellsIL-2 stimulationCD3/CD28 AbSubset of CD8TCR stimulationExpression of GATA3Aerobic glycolysis pathwayPMA/ionomycin treatmentDistal TCR signalingAnergic statusCD28 AbsPeripheral bloodHuman CD8IL-2C-myc expressionCD8IL-7Anergic cellsCalcium fluxHuman immunologyNF-AT1Nuclear translocationAerobic glycolysisIonomycin treatment
2014
Human IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469)
Sim J, Cho B, Lee S, Ko Y, Seol M, Kim J, Oh K, Lee D, Kang I, Choi K, Kim H. Human IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469). The Journal Of Immunology 2014, 192: 192.7-192.7. DOI: 10.4049/jimmunol.192.supp.192.7.Peer-Reviewed Original Research
2012
The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16)
Lee N, Lee W, Shin M, Kang Y, Jeon S, Kang I. The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16). The Journal Of Immunology 2012, 188: 105.16-105.16. DOI: 10.4049/jimmunol.188.supp.105.16.Peer-Reviewed Original ResearchEM CD8IFN-α levelsT cellsCMV infectionCytomegalovirus infectionIL-7 Receptor α ExpressionHuman effector memory CD8IL-7 receptor alphaCMV immune statusEffector memory CD8Elderly peopleT cell subsetsReceptor α expressionT cell homeostasisAge-associated expansionHigh-affinity receptorCytokine levelsMemory CD8Naïve CD8Cell subsetsImmune statusPlasma levelsCD8IL-7Α expressionAltered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10)
Kang G, Kim S, Bunin V, Shin M, Lee N, Parke A, Kang I. Altered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10). The Journal Of Immunology 2012, 188: 59.10-59.10. DOI: 10.4049/jimmunol.188.supp.59.10.Peer-Reviewed Original ResearchPrimary Sjogren's syndromeHealthy subjectsIL-7IL-17IL-23Sjogren's syndromeIL-10IL-12Peripheral bloodIL-1βIL-6Th1 cellsTh1-polarizing cytokine IL-12Anti-inflammatory cytokine IL-10Frequencies of Th17Frequency of CD4Cytokine IL-10IL-10 productionSystemic autoimmune diseaseCytokines IL-12IL-12 productionInnate immune cellsMajor proinflammatory cytokineSupernatants of lipopolysaccharideDry mouth
2010
Regulating human Th17 cells via differential expression of IL-1 receptor (34.7)
Lee W, Kang S, Choi J, Lee S, Shah K, Eynon E, Flavell R, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor (34.7). The Journal Of Immunology 2010, 184: 34.7-34.7. DOI: 10.4049/jimmunol.184.supp.34.7.Peer-Reviewed Original ResearchIL-17 productionIL-1βT cellsCell differentiationMemory CD4Differential expressionIL-1RITCR triggeringT cell receptor triggeringIL-17IL-15Naive CD4IL-7IL-1 receptor expressionIL-1RI expressionT cell populationsIL-1R antagonistCytokine IL-7Gene expressionIL-1 receptorUmbilical cord bloodReceptor triggeringDistinct CD4Peripheral bloodCord bloodHuman IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34)
Lee H, Yu M, Lee D, Kang J, Hwang Y, Lee W, Kang I, Kim H. Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34). The Journal Of Immunology 2010, 184: 132.34-132.34. DOI: 10.4049/jimmunol.184.supp.132.34.Peer-Reviewed Original ResearchIL-2 productionMemory CD8T cellsCytokine productionIL-7Effector cytokine productionT cell subsetsAnergic T cellsPMA/ionomycin treatmentAnti-CD3 AbTCR triggeringEffector cytokinesAnergic phenotypeCell subsetsHuman CD8IL-2CD8Calcium fluxTCR stimulationIonomycin treatmentCell survival responseMAPK pathwayCellular characteristicsProliferationCells
2009
Regulating human Th17 cells via differential expression of IL-1 receptor
Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2009, 115: 530-540. PMID: 19965648, PMCID: PMC2810985, DOI: 10.1182/blood-2009-08-236521.Peer-Reviewed Original ResearchConceptsT cellsIL-1RICell differentiationDifferential expressionIL-17IL-15IL-1betaIL-7T cell receptor triggeringT helper 17 (Th17) cellsIL-1 receptor expressionIL-1RI expressionIL-17 productionHelper 17 cellsT cell populationsCytokine IL-7IL-1R antagonistIL-1 receptorUmbilical cord bloodHuman peripheral bloodGene expressionReceptor triggeringPeripheral bloodCord bloodReceptor expression
2008
Dual roles of IL‐15 in maintaining IL‐7 receptor alpha low CCR7− memory CD8+ T cells in humans via recovering the PI3K/AKT pathway
Kang I, Kim H, Hwang K. Dual roles of IL‐15 in maintaining IL‐7 receptor alpha low CCR7− memory CD8+ T cells in humans via recovering the PI3K/AKT pathway. The FASEB Journal 2008, 22: 846.18-846.18. DOI: 10.1096/fasebj.22.1_supplement.846.18.Peer-Reviewed Original ResearchPI3K/Akt pathwayMemory CD8Lower CCR7IL-15T cellsAkt pathwayIL-7 receptor alphaMemory T cell survivalIL-7 receptor alpha chainHuman peripheral bloodT cell survivalReceptor alpha chainHigher CCR7Peripheral CD8T cell receptor triggeringPeripheral bloodReceptor beta chainT-betCD8IL-7CCR7Effector functionsReceptor alphaEnhanced gene expressionProliferative function
2007
Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
Kim HR, Hwang KA, Kang I. Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway. The Journal Of Immunology 2007, 179: 6734-6740. PMID: 17982063, DOI: 10.4049/jimmunol.179.10.6734.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell ProliferationCell SurvivalEnzyme ActivationGene Expression RegulationHumansImmunologic MemoryInfectionsInterleukin-15Interleukin-2 Receptor beta SubunitInterleukin-7NeoplasmsPerforinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellReceptors, CCR7Receptors, Interleukin-17Signal TransductionConceptsIL-15T cellsPI3K/Akt pathwayAkt pathwayIL-7Memory T cell survivalProliferation of ILIL-15 signalingHuman peripheral bloodT cell survivalEffector cytokinesMemory CD8Peripheral bloodEffector functionsIL-7REnhanced gene expressionProliferative functionIndependent mechanismsILTCR triggeringCell survivalSuch cellsSurvivalTranscriptional factorsDual roleDown-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation
Kim HR, Hwang KA, Kim KC, Kang I. Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation. The Journal Of Immunology 2007, 178: 5473-5479. PMID: 17442928, DOI: 10.4049/jimmunol.178.9.5473.Peer-Reviewed Original ResearchConceptsJurkat T cellsDNA methylationGene expressionGene promoterIL-7Ralpha expressionT cellsPromoter activityImportant gene regulatory mechanismGene regulatory mechanismsGene promoter constructsHuman CD8Gene promoter activityIL-7Cell survival responseT cell developmentT cell subsetsIL-7Rα expressionRegulatory mechanismsPromoter constructsCell developmentMethylationLuciferase reporterHuman T cellsSurvival responseDown regulationThe role for DNA methylation in differentially regulating IL-7 receptor alpha expression by human T cells (94.22)
Kang I, Hwang K, Kim K, Kim H. The role for DNA methylation in differentially regulating IL-7 receptor alpha expression by human T cells (94.22). The Journal Of Immunology 2007, 178: s174-s174. DOI: 10.4049/jimmunol.178.supp.94.22.Peer-Reviewed Original ResearchJurkat T cellsDNA methylationGene promoterT cellsGene expressionImportant gene regulatory mechanismHuman CD8IL-7Gene regulatory mechanismsGene promoter constructsCell survival responseReceptor alpha expressionT cell subsetsT cell developmentHuman T cellsRegulatory mechanismsPromoter activityPromoter constructsCell developmentCell subsetsIL-7RaMethylationCD8Luciferase reporterAlpha expression
2005
Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
Kim HR, Hong MS, Dan JM, Kang I. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2005, 107: 2855-2862. PMID: 16357322, PMCID: PMC1440715, DOI: 10.1182/blood-2005-09-3560.Peer-Reviewed Original ResearchConceptsIL-7 therapyT cellsT cell receptorIL-7T cell immune responsesEffector memory CD8T cell immunityT cell subsetsIL-7Rα expressionDiverse TCR repertoireIL-7Ralpha expressionIL-7Ralpha mRNAMemory CD8TCR repertoireElderly subjectsCD8Immune responseSurvival responseYoung subjectsImpaired signalingSTAT5 phosphorylationTherapyProtein alphaSurvival pathwaysCells
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response