2009
Alterations in the Kinetics of CD4+ T Cell Responses with Aging
Hong M, Dan J, Lee W, Kang I. Alterations in the Kinetics of CD4+ T Cell Responses with Aging. Journal Of Rheumatic Diseases 2009, 16: 271-280. DOI: 10.4078/jkra.2009.16.4.271.Peer-Reviewed Original ResearchKinetics of CD4T cell proliferationHr of stimulationT cell activationT cellsCD40L expressionCell proliferationCell activationPeripheral blood mononuclear cellsT cell immunityT cell responsesAnti-CD28 antibodiesBlood mononuclear cellsActivation marker CD69Duration of stimulationRisk of infectionT cell receptor stimulationAge-associated changesCell receptor stimulationYounger patientsCell immunityCD25 expressionMononuclear cellsElderly subjectsCD4
2005
Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
Kim HR, Hong MS, Dan JM, Kang I. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2005, 107: 2855-2862. PMID: 16357322, PMCID: PMC1440715, DOI: 10.1182/blood-2005-09-3560.Peer-Reviewed Original ResearchConceptsIL-7 therapyT cellsT cell receptorIL-7T cell immune responsesEffector memory CD8T cell immunityT cell subsetsIL-7Rα expressionDiverse TCR repertoireIL-7Ralpha expressionIL-7Ralpha mRNAMemory CD8TCR repertoireElderly subjectsCD8Immune responseSurvival responseYoung subjectsImpaired signalingSTAT5 phosphorylationTherapyProtein alphaSurvival pathwaysCells