2023
High-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapySystemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics
Savarimuthu S, Singh I, Khosla A. Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics. 2023, 59-69. DOI: 10.1142/9781800612778_0005.Peer-Reviewed Original ResearchHigh-risk pulmonary embolismHalf-dose thrombolysisAcute pulmonary embolismPulmonary embolismMajor bleeding eventsAdministration of thrombolyticsBleeding eventsMajor bleedsSystemic thrombolysisRespiratory failureCardiopulmonary effectsHaemodynamic collapseClinical outcomesThrombolytic therapyCardiac arrestSelect populationThrombolysisEmbolismSubstantial riskLarge-scale studiesDose considerationsOutcomesRiskThrombolyticsTherapy
2022
Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations
Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.Peer-Reviewed Original ResearchRight heart thrombusConcomitant pulmonary embolismPulmonary embolismHeart thrombusTreatment strategiesLimited clinical dataMultiple treatment strategiesMultiple medical specialtiesSystemic thrombolysisSurgical therapyExact incidenceRisk stratificationPoor outcomeUse of pointClinical dilemmaClinical dataTreatment considerationsPE managementCare ultrasoundMultiple specialtiesMedical specialtiesThrombusSpecialtiesAnticoagulationThrombolysis
2021
Chronic Thromboembolic Pulmonary Hypertension: the Bench
Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.Peer-Reviewed Original ResearchConceptsPulmonary embolismAcute pulmonary embolismThromboembolic pulmonary hypertensionPlatelet-rich thrombiPulmonary hypertensionUncommon complicationMedical therapyPulmonary vasculatureImmune cellsAnimal modelsEndothelial cellsPathobiologyPlatelet biologyThrombusHuman samplesTherapyCurrent knowledgeSummaryThe developmentCTEPHHypertensionVasculopathyCellsComplicationsEmbolismInflammationChronic Thromboembolic Pulmonary Hypertension: the Bedside
Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Current Cardiology Reports 2021, 23: 147. PMID: 34410530, PMCID: PMC8375459, DOI: 10.1007/s11886-021-01573-5.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionPulmonary embolismMedical therapyRight ventricular failureThromboembolic pulmonary hypertensionAcute pulmonary embolismArterial hypertensionPulmonary hypertensionVentricular failureUncommon complicationDisease mimicsPulmonary vasculatureMultimodality approachUnderlying pathologyPercutaneous interventionCurrent diagnosisCTEPHHypertensionTherapyDiagnosisTreatmentEmbolismComplicationsEmboliSurgery