2015
PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135)
Park H, Kim D, Kim W, Choi J. PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135). The Journal Of Immunology 2015, 194: 47.15-47.15. DOI: 10.4049/jimmunol.194.supp.47.15.Peer-Reviewed Original ResearchT cell functionT cellsPeroxisome proliferator-activated receptor gammaTh17 cellsEstrogen receptorEffector T cell functionFollicular helper T cellsHelper T cellsAuto-antibody productionExpression of Bcl-2T cell differentiationProliferator-activated receptor gammaMild autoimmune phenotypeIL-7RAPrevent autoimmunityPioglitazone treatmentGerminal centersMale miceTCR stimulationAdaptive immunityAutoimmune phenotypeDecreased expressionBcl-2MiceMouse phenotype
2014
PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation
Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation. PLOS ONE 2014, 9: e99127. PMID: 24921943, PMCID: PMC4055678, DOI: 10.1371/journal.pone.0099127.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsGerminal center reactionTfh cellsSheep red blood cell immunizationRed blood cell immunizationCenter reactionPeroxisome proliferator-activated receptor gammaIL-21 expressionProliferator-activated receptor gammaWild-type T cellsType T cellsGerminal center formationGerminal center B cellsT cell activationCell immunizationAutoantibody productionGlomerular inflammationSignature cytokinesAdaptive immunityGerminal centersGlucose metabolismNF-κBB cellsInsights into the Role of Follicular Helper T Cells in Autoimmunity
Park H, Kim D, Lim S, Kim W, Youn J, Choi Y, Choi J. Insights into the Role of Follicular Helper T Cells in Autoimmunity. Immune Network 2014, 14: 21-29. PMID: 24605077, PMCID: PMC3942504, DOI: 10.4110/in.2014.14.1.21.Peer-Reviewed Original ResearchTfh cell differentiationFollicular helper T cellsTfh cellsSystemic lupus erythematosusHelper T cellsT cellsAutoimmune diseasesB cellsBcl-6 expressionRheumatoid arthritisGerminal centersBCL-6Follicular regulatory T cellsB cell folliclesRegulatory T cellsNaïve T cellsMemory B cellsSurface moleculesCell differentiationImportant surface moleculesTfr cellsTreg cellsIL-21Lupus erythematosusPD-1