2016
BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis
Lim S, Kim W, Kim Y, Lee S, Koo J, Lee J, Kim H, Park H, Kim D, Lee H, Yoon H, Kim J, Shin J, Kim L, Doh J, Kim H, Bothwell A, Lee S, Suh M, Choi J. BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis. The Journal Of Immunology 2016, 196: 139.7-139.7. DOI: 10.4049/jimmunol.196.supp.139.7.Peer-Reviewed Original ResearchCentral nervous systemBlood-brain barrierExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsAbstract Multiple sclerosisCNS inflammatory diseasesInfiltrated T cellsEffector T cellsHelper 17 cellsSevere autoimmune diseaseT helper 1Activated T cellsMOG35-55Autoimmune encephalomyelitisTh17 responsesHelper 1Autoimmune diseasesCytokine productionSevere inflammationAntigen-4Model mice
2015
Piceatannol inhibits effector T cell functions by suppressing TcR signaling
Kim D, Lee Y, Park H, Lee J, Kim H, Hwang J, Choi J. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. International Immunopharmacology 2015, 25: 285-292. PMID: 25676533, DOI: 10.1016/j.intimp.2015.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleInterleukin-2 Receptor alpha SubunitLectins, C-TypeMice, Inbred C57BLMitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsReceptors, Antigen, T-CellSpleenStilbenesConceptsEffector T cell functionT cell functionT cellsPiceatannol treatmentT cell activation markers CD25Naïve CD4 T cellsRole of piceatannolCD4 T cellsActivation markers CD25Cell functionAdaptive immune responsesSplenic T cellsMetabolite of resveratrolMurine splenic T cellsInhibition of TCRActivated T cellsAnti-tumorigenesis activityT cell activationIL-17Th17 cellsCytokines IFNγC57BL/6 miceCytokine productionIL-2Immune response