2024
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Kandzari D, Weber M, Pathak A, Zidar J, Saxena M, David S, Schmieder R, Janas A, Langer C, Persu A, Mendelsohn F, Ameloot K, Foster M, Fischell T, Parise H, Mahfoud F. Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial. Circulation 2024, 149: 1875-1884. PMID: 38587557, DOI: 10.1161/circulationaha.124.069291.Peer-Reviewed Original ResearchSystolic blood pressureOffice systolic blood pressureRenal denervationOffice diastolic BPAmbulatory systolic BPBlood pressureSham controlsPrimary endpointBetween-group differencesNo significant differenceAntihypertensive medicationsDiastolic BPSystolic BPPresence of antihypertensive medicationBaseline-adjusted changeRenal artery dissectionMonths post-procedureSignificant differenceRenal denervation groupAmbulatory systolic blood pressureNo significant between-group differencesStatistically significant reductionSignificant between-group differencesSecondary endpointsOffice BP
2023
Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washout