2023
Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease
Godoy L, Farkouh M, Austin P, Shah B, Qiu F, Jackevicius C, Wijeysundera H, Krumholz H, Ko D. Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. Journal Of The American College Of Cardiology 2023, 81: 2299-2311. PMID: 37316110, DOI: 10.1016/j.jacc.2023.04.021.Peer-Reviewed Original ResearchConceptsStable coronary artery diseaseCoronary artery diseaseBeta-blocker groupRecent myocardial infarctionHeart failureMyocardial infarctionCardiovascular eventsCoronary angiographyPrescription claimsObstructive coronary artery diseaseIndex coronary angiographyBeta-blocker therapyBeta-blocker useHeart failure hospitalizationElective coronary angiographyNew-user designMyocardial infarction hospitalizationsCause deathCardiovascular outcomesCause mortalityFailure hospitalizationCardioprotective benefitsArtery diseasePrimary outcomeIschemic heart
2004
Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials
Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM. Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials. JAMA Internal Medicine 2004, 164: 1389-1394. PMID: 15249347, DOI: 10.1001/archinte.164.13.1389.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedBisoprololBradycardiaCarbazolesCarvedilolDizzinessFatigueFemaleFollow-Up StudiesHeart Conduction SystemHeart FailureHumansHypotensionMaleMetoprololMiddle AgedPropanolaminesRisk FactorsRisk Reduction BehaviorSeverity of Illness IndexStatistics as TopicTreatment FailureVentricular Dysfunction, LeftWithholding TreatmentConceptsBeta-blocker therapyHeart failureAdverse effectsLeft ventricular systolic dysfunctionBeta-blocker trialsCardiovascular adverse effectsChronic heart failureHeart Failure TrialVentricular systolic dysfunctionΒ-blocker therapyRisk of hypotensionLife-saving therapyRandom-effects modelHF hospitalizationCause mortalitySystolic dysfunctionCause withdrawalsFailure TrialRandomized trialsAbsolute riskElectronic searchPatientsMEDLINE databaseTherapyAbsolute increase
2002
β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction. JAMA 2002, 288: 351-357. PMID: 12117400, DOI: 10.1001/jama.288.3.351.Peer-Reviewed Original ResearchConceptsBeta-blocker therapySexual dysfunctionDepressive symptomsSymptoms of depressionAdverse eventsHeart failureMyocardial infarctionSignificant annual increaseAdditional reportsLipid solubilityAdverse effectsWithdrawal of therapyΒ-blocker therapyPatient-reported symptomsNumber of patientsEnglish-language articlesInclusion of trialsPlacebo groupMortality benefitRandomized trialsStudy treatmentCardiac patientsPlacebo controlRisk of fatigueClinical trialsClinical trials do not support strong association of beta-blocker therapy with fatigue, depression, or sexual dysfunction
Ko D, Hebert P, Coffey C, Sedrakyan A, Curtis J, Krumholz H. Clinical trials do not support strong association of beta-blocker therapy with fatigue, depression, or sexual dysfunction. Journal Of The American College Of Cardiology 2002, 39: 440. DOI: 10.1016/s0735-1097(02)81978-7.Peer-Reviewed Original Research
2001
Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma. Journal Of The American College Of Cardiology 2001, 37: 1950-1956. PMID: 11401137, DOI: 10.1016/s0735-1097(01)01225-6.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseBeta-blocker therapyAcute myocardial infarctionOne-year mortalityObstructive pulmonary diseasePulmonary diseaseElderly patientsSurvival benefitMyocardial infarctionSevere chronic obstructive pulmonary diseaseBeta-agonist therapyElderly AMI patientsSevere pulmonary diseaseCooperative Cardiovascular ProjectAsthma patientsClinical factorsAMI patientsMild diseaseClinical trialsDischarge useSevere diseaseAsthmaPatientsTherapyDisease
2000
Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction? JAMA Internal Medicine 2000, 160: 947-952. PMID: 10761959, DOI: 10.1001/archinte.160.7.947.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryPercutaneous transluminal coronary angioplastyBeta-blocker therapyAcute myocardial infarctionNonrevascularized groupCoronary revascularizationElderly patientsMyocardial infarctionNon-revascularized groupArtery bypass surgeryTransluminal coronary angioplastyClinical practice guidelinesCooperative Cardiovascular ProjectRandomized clinical trialsAmerican Heart AssociationBypass surgerySuccessful revascularizationClinical factorsCoronary angioplastyHeart AssociationPotential confoundersClinical trialsPractice guidelinesRevascularizationAmerican College
1999
Early beta-blocker therapy for acute myocardial infarction in elderly patients.
Krumholz H, Radford M, Wang Y, Chen J, Marciniak T. Early beta-blocker therapy for acute myocardial infarction in elderly patients. Annals Of Internal Medicine 1999, 131: 648-54. PMID: 10577326, DOI: 10.7326/0003-4819-131-9-199911020-00003.Peer-Reviewed Original ResearchConceptsEarly beta-blocker therapyBeta-blocker therapyAcute myocardial infarctionMyocardial infarctionElderly patientsEarly useHospital mortality ratePatients 65 yearsMedical chart reviewAcute care hospitalsYears of ageHospital mortalityHospital deathChart reviewPatient demographicsCare hospitalClinical factorsTreatment characteristicsEarly treatmentBaseline differencesObservational studyHigh riskMedicare beneficiariesMortality ratePatientsBeta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients
Chen J, Marciniak T, Radford M, Wang Y, Krumholz H. Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients. Journal Of The American College Of Cardiology 1999, 34: 1388-1394. PMID: 10551683, DOI: 10.1016/s0735-1097(99)00383-6.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyElderly diabetic patientsAcute myocardial infarctionInsulin-treated diabeticsOne-year mortalityDiabetic patientsDiabetic complicationsMyocardial infarctionNational Cooperative Cardiovascular ProjectSix-month readmission ratesOne-year mortality rateRetrospective cohort studyRisk of readmissionHospital medical recordsCooperative Cardiovascular ProjectCommunity practice settingsElderly diabeticsCohort studyComplication rateReadmission ratesSecondary preventionClinical factorsHospital readmissionRandomized trialsPotential confoundersDo “America's Best Hospitals” Perform Better for Acute Myocardial Infarction?
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction? New England Journal Of Medicine 1999, 340: 286-292. PMID: 9920954, DOI: 10.1056/nejm199901283400407.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinFemaleHealth Care SurveysHospitalsHumansLogistic ModelsMaleMedicareMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CareQuality of Health CareSeverity of Illness IndexThrombolytic TherapyUnited StatesConceptsAcute myocardial infarctionShort-term mortalityMyocardial infarctionAmerica's Best HospitalsBest HospitalsSurvival advantageLower short-term mortalityBeta-blocker therapyRates of therapyHigh rateOutcomes of patientsUse of aspirinCooperative Cardiovascular ProjectElderly Medicare beneficiariesType of hospitalQuality of hospitalsReperfusion therapyElderly patientsRate of useBypass surgeryCardiac catheterizationCoronary angioplastyMedicare beneficiariesInfarctionAspirin
1998
National Use and Effectiveness of β-Blockers for the Treatment of Elderly Patients After Acute Myocardial Infarction: National Cooperative Cardiovascular Project
Krumholz HM, Radford MJ, Wang Y, Chen J, Heiat A, Marciniak TA. National Use and Effectiveness of β-Blockers for the Treatment of Elderly Patients After Acute Myocardial Infarction: National Cooperative Cardiovascular Project. JAMA 1998, 280: 623-629. PMID: 9718054, DOI: 10.1001/jama.280.7.623.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyAcute myocardial infarctionDischarge medicationsElderly patientsMyocardial infarctionPrescribed useNational Cooperative Cardiovascular ProjectBeta-blocker prescriptionRetrospective cohort studyVentricular ejection fractionLow-risk populationCalcium channel blockersCooperative Cardiovascular ProjectFamily practice physiciansBetter survival rateEligible patientsCohort studyHospital dischargeOlder patientsSecondary preventionEjection fractionMedical chartsTreatment patternsClinical variablesPotential confounders
1996
Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes.
Krumholz HM, Radford MJ, Ellerbeck EF, Hennen J, Meehan TP, Petrillo M, Wang Y, Jencks SF. Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes. Annals Of Internal Medicine 1996, 124: 292-8. PMID: 8554223, DOI: 10.7326/0003-4819-124-3-199602010-00002.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrescription of aspirinMyocardial infarctionPatient characteristicsPrescribed useMortality rate 6 monthsBetter overall health statusRate 6 monthsBeta-blocker therapyPatients 65 yearsUse of aspirinPatient demographic characteristicsAcute care hospitalsOverall health statusPrescribed aspirinDischarge medicationsElderly patientsHospital dischargeSecondary preventionCare hospitalClinical factorsMedical chartsMultivariable analysisCardiac proceduresTreatment characteristics