Featured Publications
Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2020, 73: e1408-e1414. PMID: 32780095, PMCID: PMC8492356, DOI: 10.1093/cid/ciaa1037.Peer-Reviewed Original ResearchConceptsIntegrase strand transfer inhibitorsHuman immunodeficiency virusHazard ratioEFV groupAntiretroviral therapyStrand transfer inhibitorsClinical outcomesRisk differenceINSTI groupComposite outcomeImmunodeficiency virusClinical effectivenessNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyEnd-stage liver diseaseLong-term clinical effectivenessEnd-stage renal diseaseLong-term clinical outcomesComposite clinical outcomeFirst ART regimenInitial ART regimensAdverse clinical outcomesModern antiretroviral therapyTransfer inhibitorsAcute myocardial infarctionGeneralizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2021
Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy. AIDS 2021, 36: 277-286. PMID: 34934020, PMCID: PMC9048218, DOI: 10.1097/qad.0000000000003069.Peer-Reviewed Original ResearchConceptsEFV groupINSTI groupVirologic outcomesAntiretroviral therapyART initiationIntegrase inhibitor-based antiretroviral therapyNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyInhibitor-based antiretroviral therapyLong-term virologic outcomesIntegrase strand transfer inhibitorsFirst ART regimenInitial ART regimensRapid virologic responseStrand transfer inhibitorsART regimenCohort CollaborationInitial regimensVirologic responseVirologic suppressionART regimensVirologic effectsTreat analysisHIV treatmentLong-term effects
2019
What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men
Tang W, Huang W, Lu H, Cao B, Wu D, Ong J, Fu H, Zhang Y, Yang B, Wang C, Ma W, Wei C, Tucker J. What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men. BMC Infectious Diseases 2019, 19: 807. PMID: 31521123, PMCID: PMC6744670, DOI: 10.1186/s12879-019-4455-8.Peer-Reviewed Original ResearchConceptsFacility-based HIV testingConsistent condom useHIV testingHIV prevention servicesCondom usePrevention servicesStudy periodFacility-based testingMore implementation researchLongitudinal cohort dataHIV testIntervention trialsLongitudinal cohortChinese MSMChinese menHIVSociodemographic informationHIVSTSecondary analysisCohort dataHIVST resultsMost menImplementation researchLinear mixed modelsMenFactors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections
Yang Q, Zhang T, Zhao D, Zhang Y, Dong Y, Sun D, Du Q, Zheng J, Lu H, Dong Y. Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections. Journal Of Clinical Pharmacy And Therapeutics 2019, 45: 72-80. PMID: 31468555, DOI: 10.1111/jcpt.13026.Peer-Reviewed Original ResearchConceptsKidney transplant patientsInvasive fungal infectionsTransplant patientsConcomitant medicationsPlasma concentrationsContinuous renal replacement therapyFungal infectionsRenal replacement therapyUncontrolled observational studiesAntifungal prophylaxisKidney recipientsTrough concentrationsBaseline diseaseReplacement therapyObservational studyHealthy volunteersCyclosporine AProphylaxisHigh incidencePatientsMultivariate analysisMedicationsALB concentrationLiquid chromatography-tandem mass spectrometry methodCandida sppLeading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China
Wu D, Tang W, Lu H, Zhang T, Cao B, Ong J, Lee A, Liu C, Huang W, Fu R, Li K, Pan S, Zhang Y, Fu H, Wei C, Tucker J. Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China. Journal Of Medical Internet Research 2019, 21: e10171. PMID: 30664490, PMCID: PMC6360381, DOI: 10.2196/10171.Peer-Reviewed Original ResearchConceptsSyphilis testingMale sex partnersHealth influencersSTI informationSex partnersSociodemographic characteristicsSyphilis testing ratesUnknown HIV statusSexual behaviorInternet-Using MenLogistic regression modelsHealthy HIVHigh HIVHIV testingHIV statusMSM populationHigher oddsCondomless sexHIVTesting ratesHealthy behaviorsLeast college educationWeb-based surveyMale partnersMost menRecalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China
Cao B, Saha P, Leuba S, Lu H, Tang W, Wu D, Ong J, Liu C, Fu R, Wei C, Tucker J. Recalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China. AIDS And Behavior 2019, 23: 1240-1249. PMID: 30632008, PMCID: PMC6511317, DOI: 10.1007/s10461-019-02392-0.Peer-Reviewed Original Research
2018
Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial
Tang W, Wei C, Cao B, Wu D, Li K, Lu H, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Liu C, Huang W, Liu A, Zhang Y, Smith M, Mitchell K, Ong J, Fu H, Vickerman P, Yang L, Wang C, Zheng H, Yang B, Tucker J. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLOS Medicine 2018, 15: e1002645. PMID: 30153265, PMCID: PMC6112627, DOI: 10.1371/journal.pmed.1002645.Peer-Reviewed Original ResearchConceptsHIV testing servicesFacility-based HIV testingHIV testingHIV testSecondary outcomesSyphilis testingIntervention periodClosed cohortWedge clusterCommunity-based HIV testing servicesCondom useSelf-reported HIV testingTesting servicesControl periodHIV testing campaignsHIV testing dataHIV testing ratesHIV testing strategiesHIV testing uptakeSubset of menHIV testing interventionsMiddle-income countriesPrimary outcomeTreat analysisCluster RCTDevelopment and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database
Zhao Y, Lu H, Thai S, Li X, Hui J, Tang H, Zhai S, Sun L, Wang T. Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database. International Journal Of Clinical Pharmacy 2018, 40: 862-869. PMID: 29464448, DOI: 10.1007/s11096-018-0594-z.Peer-Reviewed Original ResearchConceptsDrug-induced anaphylaxisBeijing Pharmacovigilance DatabasePositive predictive valueAdverse drug eventsPharmacovigilance databaseAnaphylactic shockSpecific diagnosisSerious adverse drug eventsPhysician adjudicatorsChart abstractionAnaphylactic reactionsClinical criteriaDrug eventsAnaphylactoid reactionsMAIN OUTCOMEPredictive valueAnaphylaxisDiagnosisGold standardConfidence intervalsPatientsCriteria componentsHospitalDatabaseGreater number