2023
Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine
Jetsupphasuk M, Hudgens M, Lu H, Cole S, Edwards J, Adimora A, Althoff K, Silverberg M, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Moore R, Lang R, Gebo K, Rabkin C, Eron J. Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine. American Journal Of Epidemiology 2023, 192: 1341-1349. PMID: 36922393, PMCID: PMC10666965, DOI: 10.1093/aje/kwad057.Peer-Reviewed Original ResearchConceptsEfavirenz-based regimenAntiretroviral therapyPatient characteristicsComposite outcomeNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapySerious non-AIDS eventsHuman immunodeficiency virus (HIV) treatmentIntegrase strand transfer inhibitorsSame drug regimenBaseline patient characteristicsNon-AIDS eventsAbsolute risk reductionSubgroup of patientsHuman immunodeficiency virusIndividual patient characteristicsImmune deficiency syndromePrecision medicineStrand transfer inhibitorsCohort CollaborationCause mortalityDrug regimenClinical outcomesImmunodeficiency virusDeficiency syndrome
2021
Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy. AIDS 2021, 36: 277-286. PMID: 34934020, PMCID: PMC9048218, DOI: 10.1097/qad.0000000000003069.Peer-Reviewed Original ResearchConceptsEFV groupINSTI groupVirologic outcomesAntiretroviral therapyART initiationIntegrase inhibitor-based antiretroviral therapyNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyInhibitor-based antiretroviral therapyLong-term virologic outcomesIntegrase strand transfer inhibitorsFirst ART regimenInitial ART regimensRapid virologic responseStrand transfer inhibitorsART regimenCohort CollaborationInitial regimensVirologic responseVirologic suppressionART regimensVirologic effectsTreat analysisHIV treatmentLong-term effects