2016
Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa
Gilbert JA, Shenoi SV, Moll AP, Friedland GH, Paltiel AD, Galvani AP. Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa. PLOS ONE 2016, 11: e0165614. PMID: 27906986, PMCID: PMC5131994, DOI: 10.1371/journal.pone.0165614.Peer-Reviewed Original ResearchConceptsTB/HIVTB/HIV controlHIV screeningHIV controlRural South AfricaLife yearsMonths of IPTMost life yearsHigh-incidence settingsWidespread prevalenceCost-effectiveness resultsProbabilistic sensitivity analysesHIV transmissionHigh burdenTreatment coverageUnknown patientsHIVHealthcare accessDrug resistanceActive casesMonthsLifetime usePatientsYearsScreeningImpact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa
Kompala T, Moll AP, Mtungwa N, Brooks RP, Friedland GH, Shenoi SV. Impact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa. BMC Health Services Research 2016, 16: 374. PMID: 27515233, PMCID: PMC4982129, DOI: 10.1186/s12913-016-1627-8.Peer-Reviewed Original ResearchConceptsPre-ART careAntiretroviral treatmentCD4 testingCBVCT servicesTreatment cascadeRural South AfricaLocal primary care clinicsCD4 count resultsCommunity-based voluntary counselingPrimary care clinicsHIV-positive clientsPhlebotomy servicesResource-limited settingsART initiationHIV careART eligibilityCare cascadeCare clinicsHIV-positiveVoluntary counselingTreatment eligibilityCD4 resultsResult notificationResultsBetween 2010Nurse presence
2015
What motivates use of community-based human immunodeficiency virus testing in rural South Africa?
Upadhya D, Moll AP, Brooks RP, Friedland G, Shenoi SV. What motivates use of community-based human immunodeficiency virus testing in rural South Africa? International Journal Of STD & AIDS 2015, 27: 662-671. PMID: 26134323, PMCID: PMC4851612, DOI: 10.1177/0956462415592789.Peer-Reviewed Original ResearchConceptsHIV testingRural South AfricaRural resource-limited settingsHuman immunodeficiency virus (HIV) testingCommunity-based HIVCommunity-based testingMedian CD4 countRecent HIV exposureCommunity-based HIV testing programmeFirst-time testersHIV testing programsVoluntary HIV testingResource-limited settingsCD4 countHIV exposureMedian ageHIV statusVirus testingCommunity testingHIVCells/Rural settingsFamily membersSix-itemRisky lifestylesSuccessful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa
Jacobson KB, Moll AP, Friedland GH, Shenoi SV. Successful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa. PLOS ONE 2015, 10: e0127024. PMID: 25993636, PMCID: PMC4438008, DOI: 10.1371/journal.pone.0127024.Peer-Reviewed Original ResearchConceptsTB treatment outcomesTB/HIVTreatment outcomesHIV clinicDistrict hospitalRetained patientsTreatment completionTreatment successRural South AfricaSuccessful tuberculosis treatment outcomeMajor public health threatDrug-susceptible TBHospital HIV clinicLinkage of careTB treatment completionTB treatment initiationTB treatment servicesTuberculosis treatment outcomesHIV/TBBaseline disease severityNew TB casesPrimary health clinicsPrimary care levelSpecific clinical criteriaHigher treatment success
2014
Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study
Thomas TA, Heysell SK, Moodley P, Montreuil R, Ha X, Friedland G, Bamber SA, Moll AP, Gandhi N, Brant WE, Sturm W, Shah S. Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study. BMC Infectious Diseases 2014, 14: 11. PMID: 24400822, PMCID: PMC3890632, DOI: 10.1186/1471-2334-14-11.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingGastric aspiratesTB suspectsObservational studySpecimen collectionDrug-susceptible TBNew TB suspectsPediatric TB suspectsTB treatment historyXDR-TB casesMultiple specimen typesYears of ageSame-day methodTB settingsInduced sputumPersistent symptomsSputum inductionTB treatmentHIV statusNegative childrenTB diagnosisUrine cultureMean ageInpatient settingDiagnostic yield
2013
A Pilot Study of an mHealth Application for Healthcare Workers: Poor Uptake Despite High Reported Acceptability at a Rural South African Community-Based MDR-TB Treatment Program
Chaiyachati KH, Loveday M, Lorenz S, Lesh N, Larkan LM, Cinti S, Friedland GH, Haberer JE. A Pilot Study of an mHealth Application for Healthcare Workers: Poor Uptake Despite High Reported Acceptability at a Rural South African Community-Based MDR-TB Treatment Program. PLOS ONE 2013, 8: e64662. PMID: 23724075, PMCID: PMC3665589, DOI: 10.1371/journal.pone.0064662.Peer-Reviewed Original ResearchConceptsAdverse event formsMDR-TB patientsMDR-TB therapyHealthcare workersMobile healthcare workersMDR-TB treatment programmeMultidrug-resistant tuberculosis epidemicPoor uptakeAdverse clinical eventsResource-poor settingsRural South African communityEvent formsMixed-methods evaluationClinical eventsSpecialty centersCommunity hospitalHCWs' perceptionsTuberculosis epidemicOwn careIntensive phaseHealth professionalsHealth interventionsPoor settingsTreatment programQualitative focus groups
2012
Tuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills
Kanjee Z, Amico KR, Li F, Mbolekwa K, Moll AP, Friedland GH. Tuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills. Journal Of Infection And Public Health 2012, 5: 67-81. PMID: 22341846, DOI: 10.1016/j.jiph.2011.10.008.Peer-Reviewed Original ResearchConceptsTB infection controlRural South African hospitalSouth African hospitalsInfection controlHIV statusAfrican hospitalsTuberculosis infection controlDrug-resistant tuberculosisBehavioral skillsCough hygieneSocial support itemsPresent studyRural South AfricaResource-limited facilitiesHigh-risk areasAnonymous questionnaireIMB modelTuberculosisRespondents' knowledgeSuch interventionsHospitalHCWsIC practicesMost respondentsSocial support
2011
Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff
Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH. Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. Journal Of Hospital Infection 2011, 79: 333-338. PMID: 21978608, DOI: 10.1016/j.jhin.2011.06.017.Peer-Reviewed Original ResearchConceptsMDR-TB/XDRHuman immunodeficiency virus statusRural South African hospitalNosocomial TB transmissionStigma of TBTuberculosis infection controlTB/HIVDrug-resistant TBInfection control knowledgeHealth informationSouth African hospitalsSurvey of knowledgeBehavioral change interventionsTB-ICTB infectionXDR-TBTB deathsTB transmissionVirus statusHealthcare workersAfrican hospitalsInfection controlHospital staffRural South AfricaBaseline assessmentPrevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal
Heysell SK, Shenoi SV, Catterick K, Thomas TA, Friedland G. Prevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal. South African Medical Journal 2011, 101: 332-334. PMID: 21837877, PMCID: PMC3628595, DOI: 10.7196/samj.4462.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusTB wardsNasal carriageMRSA isolatesNasal swabsImpact of MRSAMethicillin-resistant Staphylococcus aureus nasal carriageStaphylococcus aureus nasal carriageLow CD4 countRural African hospitalAureus nasal carriageHours of admissionMRSA nasal carriageGovernment district hospitalsStandard disk diffusionImportant nosocomial pathogenRural KwaZulu-NatalAdmission swabCD4 countHospitalised patientsMRSA carriageNosocomial acquisitionTB patientsPrevious hospitalisationMedical charts
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremiaExtensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa.
Thomas TA, Shenoi SV, Heysell SK, Eksteen FJ, Sunkari VB, Gandhi NR, Friedland G, Shah NS. Extensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa. The International Journal Of Tuberculosis And Lung Disease 2010, 14: 1244-51. PMID: 20843414, PMCID: PMC3030274.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusXDR-TB diagnosisXDR-TBDrug-resistant tuberculosisPediatric wardImmunodeficiency virusRural South AfricaXDR-TB patientsXDR-TB treatmentActive antiretroviral therapySputum culture conversionNeuropsychiatric side effectsHospital pediatric wardInfection control policiesCulture conversionAntiretroviral therapyRadiographic improvementNosocomial transmissionOverlapping toxicitiesMicrobiologic dataHIV treatmentMedical recordsMicrobiologic diagnosisHIV therapyPrevious historyExtensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC
Heysell SK, Moll AP, Gandhi NR, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah NS, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N. Extensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2010, 16: 557-560. PMID: 20202446, PMCID: PMC3322040, DOI: 10.3201/eid1603.091486.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntitubercular AgentsBiopsy, Fine-NeedleCulture MediaDrug Resistance, Multiple, BacterialExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansLymph NodesMaleMicrobial Sensitivity TestsMycobacterium tuberculosisPleural EffusionRural PopulationSouth Africa
2009
Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study
Gandhi NR, Moll AP, Lalloo U, Pawinski R, Zeller K, Moodley P, Meyer E, Friedland G. Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 50: 37-43. PMID: 19295333, DOI: 10.1097/qai.0b013e31818ce6c4.Peer-Reviewed Original ResearchConceptsTB/HIV-coinfected patientsHIV treatmentCubic millimeterCD4 count increaseDaily antiretroviral therapyImmune reconstitution eventsIntegration of tuberculosisMedian CD4 countUndetectable viral loadSevere adverse eventsDrug-resistant tuberculosisRural resource-poor settingsCause of deathHome-based therapyResource-poor settingsRural KwaZulu-NatalARV dosesTreatment defaultAntiretroviral therapyCD4 countHIV careOperational research studyTB patientsAdverse eventsObserved therapy
2007
Implementation Issues in Tuberculosis/HIV Program Collaboration and Integration: 3 Case Studies
Friedland G, Harries A, Coetzee D. Implementation Issues in Tuberculosis/HIV Program Collaboration and Integration: 3 Case Studies. The Journal Of Infectious Diseases 2007, 196: s114-s123. PMID: 17624820, DOI: 10.1086/518664.Peer-Reviewed Original ResearchConceptsTB/HIV service integrationHIV service integrationNeeds of patientsPublic health approachWorld Health OrganizationHIV diseaseNational TuberculosisHIV programsHIV interactionsInfection influenceHealth approachSuccessful outcomeTuberculosisDiseaseHealth OrganizationLarge national programProgram settingsSmall demonstration projectsMost settingsOutcomesImplementation of programsProgram collaborationNational programLarge populationService integration