2018
Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa
Bionghi N, Daftary A, Maharaj B, Msibi Z, Amico K, Friedland G, Orrell C, Padayatchi N, O’Donnell M. Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa. BMC Infectious Diseases 2018, 18: 171. PMID: 29642874, PMCID: PMC5896111, DOI: 10.1186/s12879-018-3080-2.Peer-Reviewed Original ResearchConceptsAnti-retroviral therapySeven-day recallPill countMedication adherenceWisepill deviceTreatment regimensTB/HIV co-infected patientsHIV co-infected adultsHIV co-infected patientsDrug-resistant tuberculosis treatmentCo-infected adultsCo-infected patientsDR-TB treatmentPilot study patientsWeekly pill countsComplex treatment regimensElectronic pill boxesLevel of adherenceTB regimensAdherence supportAntiretroviral therapyHIV patientsStudy patientsMethodsEligible patientsNew antimycobacterial drugs
2013
A Pilot Study of an mHealth Application for Healthcare Workers: Poor Uptake Despite High Reported Acceptability at a Rural South African Community-Based MDR-TB Treatment Program
Chaiyachati KH, Loveday M, Lorenz S, Lesh N, Larkan LM, Cinti S, Friedland GH, Haberer JE. A Pilot Study of an mHealth Application for Healthcare Workers: Poor Uptake Despite High Reported Acceptability at a Rural South African Community-Based MDR-TB Treatment Program. PLOS ONE 2013, 8: e64662. PMID: 23724075, PMCID: PMC3665589, DOI: 10.1371/journal.pone.0064662.Peer-Reviewed Original ResearchConceptsAdverse event formsMDR-TB patientsMDR-TB therapyHealthcare workersMobile healthcare workersMDR-TB treatment programmeMultidrug-resistant tuberculosis epidemicPoor uptakeAdverse clinical eventsResource-poor settingsRural South African communityEvent formsMixed-methods evaluationClinical eventsSpecialty centersCommunity hospitalHCWs' perceptionsTuberculosis epidemicOwn careIntensive phaseHealth professionalsHealth interventionsPoor settingsTreatment programQualitative focus groups
2008
Clinic-Based Intervention Reduces Unprotected Sexual Behavior Among HIV-Infected Patients in KwaZulu-Natal, South Africa: Results of a Pilot Study
Cornman DH, Kiene SM, Christie S, Fisher WA, Shuper PA, Pillay S, Friedland GH, Thomas CM, Lodge L, Fisher JD. Clinic-Based Intervention Reduces Unprotected Sexual Behavior Among HIV-Infected Patients in KwaZulu-Natal, South Africa: Results of a Pilot Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2008, 48: 553-560. PMID: 18645518, PMCID: PMC2813056, DOI: 10.1097/qai.0b013e31817bebd7.Peer-Reviewed Original ResearchConceptsUnprotected sexual behaviorPrevention interventionsClinical careBrief risk reduction interventionHuman immunodeficiency virus prevention interventionsSexual behaviorUnprotected sex eventsCare control conditionRoutine clinical careHIV prevention interventionsRoutine patient visitsSex eventsClinical care settingsRisk reduction interventionsCounselor-delivered interventionUnprotected sexual eventsPatient visitsCare settingsSelf-report questionnairesUrban hospitalPatientsHIVIntervention counselorsReduction interventionsClinical encounters
2004
A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting
Jack C, Lalloo U, Karim QA, Karim SA, El-Sadr W, Cassol S, Friedland G. A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2004, 36: 929-934. PMID: 15220699, DOI: 10.1097/00126334-200408010-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAlkynesAntibiotics, AntitubercularAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBenzoxazinesCosts and Cost AnalysisCyclopropanesDidanosineDrug Therapy, CombinationFemaleHIV InfectionsHumansLamivudineMaleMiddle AgedOutpatient Clinics, HospitalOxazinesPilot ProjectsSouth AfricaTreatment OutcomeTuberculosisUrban PopulationConceptsAntiretroviral therapyTB therapyViral loadPilot studyTwenty HIV-positive patientsSmear-positive pulmonary TBCD4 count increaseDrug-sensitive TBObserved therapy programStandard TB therapyActive antiretroviral therapyHIV-positive patientsMean CD4 countMean viral loadCells/Resource limited settingsResource-limited settingsDaily didanosineHAART regimenCD4 countHIV clinicPulmonary TBTB clinicNeurologic toxicityObserved therapy
2003
Pilot study to enhance HIV care using needle exchange-based health services for out-of-treatment injecting drug users
Altice FL, Springer S, Buitrago M, Hunt DP, Friedland GH. Pilot study to enhance HIV care using needle exchange-based health services for out-of-treatment injecting drug users. Journal Of Urban Health 2003, 80: 416-427. PMID: 12930880, PMCID: PMC3455979, DOI: 10.1093/jurban/jtg053.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusNondetectable viral loadCD4 lymphocyte countDrug treatmentDrug usersLymphocyte countViral loadHIV therapyBaseline HIV-1 RNA levelsNeedle exchangeHealth servicesHIV-1 RNA levelsPilot studyPotent antiretroviral combinationUtilization of HAARTActive antiretroviral therapyAntiretroviral therapy regimensHIV-1 RNACommunity-based health interventionsAdverse side effectsActive drug usersFormal drug treatmentImmunodeficiency syndrome (AIDS) incidenceSmall pilot studyActive heroin injectors