2013
Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Lygizos M, Shenoi SV, Brooks RP, Bhushan A, Brust J, Zelterman D, Deng Y, Northrup V, Moll AP, Friedland GH. Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa. BMC Infectious Diseases 2013, 13: 300. PMID: 23815441, PMCID: PMC3716713, DOI: 10.1186/1471-2334-13-300.Peer-Reviewed Original ResearchConceptsTB transmission riskInfectious TB patientsTransmission riskTB patientsRural South AfricaDrug-resistant TBTB control effortsHealth care facilitiesPaucity of dataHousehold settingsRural KwaZulu-NatalPrevalent TBResistant TBTB transmissionCare facilitiesMultivariate analysisHIV areasVentilationAChSignificant decreaseWells-Riley equationPatientsRiskLow ventilationHour period
2011
Prevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal
Heysell SK, Shenoi SV, Catterick K, Thomas TA, Friedland G. Prevalence of methicillin-resistant Staphylococcus aureus nasal carriage among hospitalised patients with tuberculosis in rural KwaZulu-Natal. South African Medical Journal 2011, 101: 332-334. PMID: 21837877, PMCID: PMC3628595, DOI: 10.7196/samj.4462.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusTB wardsNasal carriageMRSA isolatesNasal swabsImpact of MRSAMethicillin-resistant Staphylococcus aureus nasal carriageStaphylococcus aureus nasal carriageLow CD4 countRural African hospitalAureus nasal carriageHours of admissionMRSA nasal carriageGovernment district hospitalsStandard disk diffusionImportant nosocomial pathogenRural KwaZulu-NatalAdmission swabCD4 countHospitalised patientsMRSA carriageNosocomial acquisitionTB patientsPrevious hospitalisationMedical charts
2009
HIV Coinfection in Multidrug- and Extensively Drug-Resistant Tuberculosis Results in High Early Mortality
Gandhi NR, Shah NS, Andrews JR, Vella V, Moll AP, Scott M, Weissman D, Marra C, Lalloo UG, Friedland GH. HIV Coinfection in Multidrug- and Extensively Drug-Resistant Tuberculosis Results in High Early Mortality. American Journal Of Respiratory And Critical Care Medicine 2009, 181: 80-86. PMID: 19833824, DOI: 10.1164/rccm.200907-0989oc.Peer-Reviewed Original ResearchConceptsXDR-TB casesHIV coinfection rateXDR-TB patientsOne-year mortalityTB casesXDR-TBTB patientsMDR-TBSputum collectionDrug-resistant tuberculosis epidemicHigh HIV prevalence regionsDrug susceptibility test resultsYear of diagnosisRetrospective observational studyHigh early mortalityAvailable medical recordsMajority of deathsHIV coinfectionAntiretroviral therapyHIV statusEarly mortalityMedical recordsTuberculosis resultsEarly initiationObservational studySuccessful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study
Gandhi NR, Moll AP, Lalloo U, Pawinski R, Zeller K, Moodley P, Meyer E, Friedland G. Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 50: 37-43. PMID: 19295333, DOI: 10.1097/qai.0b013e31818ce6c4.Peer-Reviewed Original ResearchConceptsTB/HIV-coinfected patientsHIV treatmentCubic millimeterCD4 count increaseDaily antiretroviral therapyImmune reconstitution eventsIntegration of tuberculosisMedian CD4 countUndetectable viral loadSevere adverse eventsDrug-resistant tuberculosisRural resource-poor settingsCause of deathHome-based therapyResource-poor settingsRural KwaZulu-NatalARV dosesTreatment defaultAntiretroviral therapyCD4 countHIV careOperational research studyTB patientsAdverse eventsObserved therapy