2004
Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8
Cassol E, Page T, Mosam A, Friedland G, Jack C, Lalloo U, Kopetka J, Patterson B, Esterhuizen T, Coovadia HM. Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8. The Journal Of Infectious Diseases 2004, 191: 324-332. PMID: 15633090, DOI: 10.1086/427337.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHerpesvirus 8, HumanHIV InfectionsHIV-1HumansMaleMiddle AgedMycobacterium tuberculosisReverse Transcriptase InhibitorsRNA, ViralSarcoma, KaposiTreatment OutcomeTuberculosis, PulmonaryViral LoadConceptsKaposi's sarcomaHIV-1Opportunistic infectionsViral loadAfrican patientsUndetectable HIV-1 RNA levelsCell countHIV-1 RNA levelsPlasma HIV-1 levelsHuman immunodeficiency virus (HIV) infectionHIV-1 subtype CKaplan-Meier survival analysisMycobacterium tuberculosisHIV-1 levelsImmunodeficiency virus infectionProportion of patientsTarget cell availabilityHuman herpesvirus 8Immune activationTreatment regimensSubtype CTherapeutic responseTreatment outcomesVirus infectionHerpesvirus 8
2003
Use of Total Lymphocyte Count for Monitoring Response to Antiretroviral Therapy
Schreibman T, Friedland G. Use of Total Lymphocyte Count for Monitoring Response to Antiretroviral Therapy. Clinical Infectious Diseases 2003, 38: 257-262. PMID: 14699459, DOI: 10.1086/380792.Peer-Reviewed Original ResearchConceptsTotal lymphocyte countCD4 cell countAntiretroviral therapyCell countLymphocyte countHuman immunodeficiency virus (HIV) diseaseOpportunistic infection prophylaxisPotential surrogate markerResource-limited settingsHIV diseaseInfection prophylaxisLaboratory markersOpportunistic infectionsSurrogate markerDisease progressionClinical utilityImmune functionTherapeutic interventionsTherapyKey laboratory measurementsMonitoring responseVirus diseaseLack of availabilityDiseaseCount
1988
Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS
Selwyn P, Feingold A, Hartel D, Schoenbaum E, Alderman M, Klein R, Friedland G. Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS. AIDS 1988, 2: 267-272. PMID: 3140832, DOI: 10.1097/00002030-198808000-00005.Peer-Reviewed Original ResearchConceptsIntravenous drug usersIntravenous drug useBacterial pneumoniaHIV infectionDrug usersDrug useActive intravenous drug useCommunity-acquired bacterial pneumoniaCumulative yearly incidenceMethadone maintenance programSeronegative subjectsSeropositive patientsSeropositive subjectsStudy entryOpportunistic infectionsYearly incidencePneumoniaHemophilus influenzaeStreptococcus pneumoniaeSeropositivesHIVAIDSInfectionStudy periodIncidence
1986
Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome
Saltzman B, Motyl M, Friedland G, McKitrick J, Klein R. Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome. JAMA 1986, 256: 390-391. PMID: 3088290, DOI: 10.1001/jama.1986.03380030092036.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeImmunodeficiency syndromeCellular immunityM tuberculosisMycobacterium avium-intracellulare infectionDisease Control case definitionMycobacterium tuberculosis bacteremiaIntravenous drug abusersUnusual malignant neoplasmFive-year historyIntravenous heroinOpportunistic infectionsDisseminated infectionMalignant neoplasmsCase definitionBacteremiaCocaine abuseDrug abusersBacterial infectionsInfectionMycobacterium tuberculosisWeight lossTuberculosisPatientsSyndrome
1984
Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome
Klein R, Harris C, Small C, Moll B, Lesser M, Friedland G. Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome. New England Journal Of Medicine 1984, 311: 354-358. PMID: 6738653, DOI: 10.1056/nejm198408093110602.Peer-Reviewed Original ResearchConceptsT4/T8 ratioOral candidiasisT8 ratioImmunodeficiency syndromeOpportunistic infectionsHigh-risk patientsMajor opportunistic infectionIntravenous drug abusersAcquired Immunodeficiency SyndromeSerious opportunistic infectionsGeneralized lymphadenopathyInitial manifestationSimilar patientsKaposi's sarcomaHigh riskPatientsHealthy adultsCandidiasisLymphadenopathyBisexual menAIDSSarcomaSyndromeInfectionMonths
1983
Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men
Small C, Klein R, Friedland G, Moll B, Emeson E, Spigland I. Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men. The American Journal Of Medicine 1983, 74: 433-441. PMID: 6219579, DOI: 10.1016/0002-9343(83)90970-1.Peer-Reviewed Original ResearchConceptsOpportunistic infectionsSevere opportunistic infectionsHomosexual menDrug abusersOral thrushCellular immunityT helper/inducer cellsT suppressor/cytotoxic cellsHelper/inducer cellsSuppressor/cytotoxic cellsHealthy young patientsSyndrome of immunodeficiencyPneumocystis carinii pneumoniaMycobacterium intracellulare infectionDefective cellular immunityWhite homosexual menCutaneous anergyCandida esophagitisYounger patientsNonspecific findingsClinical presentationCarinii pneumoniaCytotoxic cellsInducer cellsIntracellulare infection
1982
Inverted ratio of inducer to suppressor T-lymphocyte subsets in drug abusers with opportunistic infections
Moll B, Emeson E, Small C, Friedland G, Klein R, Spigland I. Inverted ratio of inducer to suppressor T-lymphocyte subsets in drug abusers with opportunistic infections. Clinical Immunology 1982, 25: 417-423. PMID: 6218947, DOI: 10.1016/0090-1229(82)90206-9.Peer-Reviewed Original ResearchConceptsT lymphocyte subsetsOpportunistic infectionsOnly opportunistic infectionPercentage of T8Pneumocystis carinii pneumoniaPercentage of T4Ratio of inducerCutaneous anergyCarinii pneumoniaImmune statusPeripheral bloodOral candidiasisProliferative responsePatientsDrug abusersDrug abuseMarked reductionInfectionP. cariniiLymphocytesFurther evidencePneumoniaAnergyHistoplasmosisCandidiasis