2011
Mycobacterium Tuberculosis Resistant To Nine First- And Second-Line TB Drugs In An HIV-Infected Child From Rural South Africa
Thomas T, Heysell S, Eksteen F, Moodley P, Moll A, Sturm A, Friedland G, Shah S. Mycobacterium Tuberculosis Resistant To Nine First- And Second-Line TB Drugs In An HIV-Infected Child From Rural South Africa. 2011, a5714-a5714. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5714.Peer-Reviewed Original ResearchIncreasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC
Shah NS, Richardson J, Moodley P, Moodley S, Babaria P, Ramtahal M, Heysell SK, Li X, Moll AP, Friedland G, Sturm AW, Gandhi NR. Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 510-513. PMID: 21392446, PMCID: PMC3166021, DOI: 10.3201/eid1703.101363.Peer-Reviewed Original ResearchConceptsExtensively Drug-Resistant TuberculosisTuberculosis drug susceptibility testingDrug-resistant Mycobacterium tuberculosisInfectious Diseases journal - CDCDrug-resistant TBDrug-resistant tuberculosisDrug susceptibility testingEffective treatmentAvailable drugsDrug resistanceSusceptibility testingMycobacterium tuberculosisTuberculosisDrugsPatients
2010
Pharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers
Wallis RS, Jakubiec WM, Kumar V, Silvia AM, Paige D, Dimitrova D, Li X, Ladutko L, Campbell S, Friedland G, Mitton-Fry M, Miller PF. Pharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers. The Journal Of Infectious Diseases 2010, 202: 745-751. PMID: 20629533, DOI: 10.1086/655471.Peer-Reviewed Original ResearchConceptsWhole-blood bactericidal activityMean maximal concentrationPNU-100480Single dosesMinimum inhibitory concentrationHealthy volunteersBactericidal activityMycobacterium tuberculosisExperimental murine tuberculosisSingle ascending dosesSingle oral dosesDrug-resistant tuberculosisMaximal concentrationInhibitory concentrationAscending dosesMurine tuberculosisExposure of parentsOral dosesDaily dosesLog/dayLinezolidDrug concentrationsTuberculosisMycobactericidal activityDosesExtensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC
Heysell SK, Moll AP, Gandhi NR, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah NS, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N. Extensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2010, 16: 557-560. PMID: 20202446, PMCID: PMC3322040, DOI: 10.3201/eid1603.091486.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntitubercular AgentsBiopsy, Fine-NeedleCulture MediaDrug Resistance, Multiple, BacterialExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansLymph NodesMaleMicrobial Sensitivity TestsMycobacterium tuberculosisPleural EffusionRural PopulationSouth Africa
2004
Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8
Cassol E, Page T, Mosam A, Friedland G, Jack C, Lalloo U, Kopetka J, Patterson B, Esterhuizen T, Coovadia HM. Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8. The Journal Of Infectious Diseases 2004, 191: 324-332. PMID: 15633090, DOI: 10.1086/427337.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHerpesvirus 8, HumanHIV InfectionsHIV-1HumansMaleMiddle AgedMycobacterium tuberculosisReverse Transcriptase InhibitorsRNA, ViralSarcoma, KaposiTreatment OutcomeTuberculosis, PulmonaryViral LoadConceptsKaposi's sarcomaHIV-1Opportunistic infectionsViral loadAfrican patientsUndetectable HIV-1 RNA levelsCell countHIV-1 RNA levelsPlasma HIV-1 levelsHuman immunodeficiency virus (HIV) infectionHIV-1 subtype CKaplan-Meier survival analysisMycobacterium tuberculosisHIV-1 levelsImmunodeficiency virus infectionProportion of patientsTarget cell availabilityHuman herpesvirus 8Immune activationTreatment regimensSubtype CTherapeutic responseTreatment outcomesVirus infectionHerpesvirus 8
1990
The Recovery of Mycobacterium avium Complex and Mycobacterium tuberculosis from Blood Specimens of AIDS Patients Using the Nonradiometric BACTEC NR 660 Medium
Motyl M, Saltzman B, Levi M, Mckitrick J, Friedland G, Klein R. The Recovery of Mycobacterium avium Complex and Mycobacterium tuberculosis from Blood Specimens of AIDS Patients Using the Nonradiometric BACTEC NR 660 Medium. American Journal Of Clinical Pathology 1990, 94: 84-86. PMID: 2113765, DOI: 10.1093/ajcp/94.1.84.Peer-Reviewed Original ResearchConceptsAIDS patientsMycobacterium avium complexAvium complexBlood culturesMycobacterial mediaM. tuberculosisMycobacterium tuberculosisFemale AIDS patientsAcid-fast stainAliquots of mediumM. avium complexMale patientsFast stainBlood specimensPositive culturesBlood culture mediaPatientsTuberculosisMicrobiology laboratoryMycobacterial growthSignificant differencesMycobacteriaReference strainsPercentBacteremia
1986
Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome
Saltzman B, Motyl M, Friedland G, McKitrick J, Klein R. Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome. JAMA 1986, 256: 390-391. PMID: 3088290, DOI: 10.1001/jama.1986.03380030092036.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeImmunodeficiency syndromeCellular immunityM tuberculosisMycobacterium avium-intracellulare infectionDisease Control case definitionMycobacterium tuberculosis bacteremiaIntravenous drug abusersUnusual malignant neoplasmFive-year historyIntravenous heroinOpportunistic infectionsDisseminated infectionMalignant neoplasmsCase definitionBacteremiaCocaine abuseDrug abusersBacterial infectionsInfectionMycobacterium tuberculosisWeight lossTuberculosisPatientsSyndrome