Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practiceInduction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice
Maskey A, Srivastava K, Soffer G, Dunkin D, Yuan Q, Li X. Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice. Journal Of Inflammation Research 2022, 15: 5527-5540. PMID: 36176352, PMCID: PMC9514888, DOI: 10.2147/jir.s372449.Peer-Reviewed Original ResearchAirborne allergensNormal controlsEosinophilic inflammationEosinophilic esophagitisTh2 cytokinesAntigen-specific IgE levelsCommon chronic inflammatory diseaseImportant pathologic roleMild eosinophilic inflammationSevere eosinophilic esophagitisSevere eosinophilic inflammationIL-4/ILBronchoalveolar lavage fluidChronic inflammatory diseaseMulti-organ inflammationGene-deficient miceChemokine gene expressionIgA levelsIgE levelsIgG levelsSerum totalSpecific IgETotal IgAWT miceLavage fluidA Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE
Maskey A, Wang Z, Chen X, Dunkin D, Soffer G, Yuan Q, Li X. A Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4598.Peer-Reviewed Original ResearchLevels of TNFManagement of EoEIL-6Biopsy samplesAbnormal bowel movementsProlonged steroid useDihydroxy flavonesHigh relapse rateRisk of cancerAGE-RAGE pathwayHigh response rateSignificant reductionTraditional Chinese medicine practiceEase of administrationPathway analysisDietary eliminationOral steroidsSystemic steroidsAbdominal painBowel movementsEsophageal dysfunctionGI symptomsMaintenance therapyEosinophilic inflammationGastrointestinal reflux