2007
Cutaneous T-cell lymphoma: Biologic targets for therapy
Choi J, Foss F. Cutaneous T-cell lymphoma: Biologic targets for therapy. Current Hematologic Malignancy Reports 2007, 2: 272-277. PMID: 20425380, DOI: 10.1007/s11899-007-0037-8.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsApoptosisCD4 AntigensClinical Trials as TopicDiphtheria ToxinDrug Delivery SystemsDrug DesignEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansImmunologic FactorsImmunotherapyInterferon-gammaInterleukin-2Lymphoma, T-Cell, CutaneousNeoplasm ProteinsPhotopheresisRecombinant Fusion ProteinsSkin NeoplasmsT-Lymphocyte SubsetsTumor EscapeConceptsCutaneous T-cell lymphomaReceptor-dependent signaling pathwaysEpigenetic changesSignaling pathwaysClonal populationsSkin-homing lymphocytesT-cell lymphomaT cell activationPersistence of tumorHost immune systemCTCL cellsCancer immunosurveillanceImmune cellsLangerhans cellsCytotoxic phenotypeDisease pathogenesisBiologic targetsImmune systemCellsTherapyDiseasePhenotypePathwayImmunosurveillanceActivation
2002
Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells
Urbano A, Gorgun G, Foss F. Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells. Biochemical Pharmacology 2002, 63: 689-692. PMID: 11992636, DOI: 10.1016/s0006-2952(01)00916-9.Peer-Reviewed Original ResearchConceptsCytochrome c/ApafPhosphatidylinositol-3-kinase/AktHematopoietic cellsTyrphostin tyrosine kinase inhibitorKinase/AktChronic myelogenous leukemia blastsMechanism of apoptosisCell line NALM-6BAD complexLeukemia cellsPhosphorylation stateC-CblAdaptor moleculeGrowth arrestAltered phosphorylationChronic myelogenous leukemia cellsMyelogenous leukemia cellsProgenitor cellsApoptosisTyrphostin AG957AG957NALM-6Kinase inhibitorsGrowth inhibitionAkt