2014
PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial
Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, Patel MR, Picard MH, Udelson JE, Velazquez EJ, Cooper L, investigators P. PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial. American Heart Journal 2014, 167: 796-803.e1. PMID: 24890527, PMCID: PMC4044617, DOI: 10.1016/j.ahj.2014.03.003.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePROMISE trialAnatomical testingProspective Multicenter Imaging StudyDiagnostic strategiesInitial diagnostic strategyMajor procedural complicationsSubsequent care decisionsComposite of deathPrimary end pointLarge pragmatic trialClinical care teamQuality of lifeDiagnostic testing strategiesMultidetector coronaryChest painSymptomatic patientsUnstable anginaArtery diseaseProcedural complicationsRandomized trialsSymptomatic subjectsClinical effectivenessMyocardial infarctionPragmatic trial
2010
Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging
Samad Z, Atchley AE, Trimble MA, Sun JL, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2010, 18: 24-30. PMID: 21082299, PMCID: PMC3077282, DOI: 10.1007/s12350-010-9310-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedIncidenceMaleMyocardial Perfusion ImagingNorth CarolinaPrevalenceReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityVentricular Dysfunction, LeftConceptsLeft ventricular dysfunctionMechanical dyssynchronyVentricular dysfunctionIndependent predictorsBlack raceQRS durationPhase SDGated SPECT myocardial perfusionLeft ventricular ejection fractionTomography myocardial perfusion imagingStress scoresVentricular ejection fractionIschemic heart diseasePopulation of patientsMeasures of dyssynchronySPECT myocardial perfusionMyocardial perfusion imagingSingle photon emissionSignificant dyssynchronyEjection fractionEntire cohortUnivariate predictorsClinical variablesHeart diseaseMale genderDoes Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction?
Mudrick DW, Velazquez E, Borges-Neto S. Does Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction? Current Cardiology Reports 2010, 12: 155-161. PMID: 20425171, DOI: 10.1007/s11886-010-0093-x.Peer-Reviewed Original ResearchMeSH KeywordsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyCoronary Artery DiseaseDeath, Sudden, CardiacHumansMass ScreeningMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsPrognosisRisk AssessmentSensitivity and SpecificityStroke VolumeVentricular Function, LeftConceptsEjection fractionVentricular functionNonfatal cardiac eventsGated single-photon emissionIncremental prognostic informationSignificant coronary diseaseVentricular ejection fractionCoronary artery diseaseOptimal treatment strategySudden cardiac deathNuclear imaging studiesImportant clinical implicationsMyocardial perfusion imagingPositron emission tomographySingle photon emissionIschemic burdenCardiac eventsArtery diseaseCardiac deathCoronary diseasePrognostic informationTreatment strategiesMyocardial perfusionPerfusion imagingBest predictor
2009
Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction
Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2009, 16: 888-894. PMID: 19690935, PMCID: PMC3048054, DOI: 10.1007/s12350-009-9136-3.Peer-Reviewed Original ResearchConceptsModerate LV dysfunctionSevere LV dysfunctionLV dysfunctionMechanical dyssynchronyQRS durationNormal controlsGated SPECTModerate left ventricular dysfunctionNYHA class IIIPrevalence of dyssynchronyLeft ventricular dysfunctionCohort of patientsMajority of patientsLV mechanical dyssynchronyGated SPECT imagingCurrent selection criteriaLess dyssynchronyLVEF 35More dyssynchronyVentricular dysfunctionPatient selectionDyssynchronyPatientsSPECT perfusionDysfunction
2008
Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging
Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges‐Neto S, Velazquez EJ, Iskandrian AE. Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging. Echocardiography 2008, 25: 1186-1194. PMID: 18986406, DOI: 10.1111/j.1540-8175.2008.00782.x.Peer-Reviewed Original ResearchMeSH KeywordsElectrocardiographyHumansMyocardial Perfusion ImagingPredictive Value of TestsTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyMyocardial perfusion imagingTissue Doppler imagingLV dyssynchronyPerfusion imagingTomography myocardial perfusion imagingSPECT myocardial perfusion imagingElectrocardiography-gated single-photon emissionSevere heart failureVentricular mechanical dyssynchronySingle photon emissionHeart failureMechanical dyssynchronyResynchronization therapyClinical evaluationDyssynchronyLeft ventricleDoppler imagingPatientsRegional wallMechanical contractionPhoton emissionCardiac cycleImportant predictorFourier harmonic functions