2014
Bcl-xL in neuroprotection and plasticity
Jonas EA, Porter GA, Alavian KN. Bcl-xL in neuroprotection and plasticity. Frontiers In Physiology 2014, 5: 355. PMID: 25278904, PMCID: PMC4166110, DOI: 10.3389/fphys.2014.00355.BooksMitochondrial outer membrane permeabilizationBcl-xLSynapse formationOuter membrane permeabilizationMaster regulator proteinBcl-2 family member Bcl-xLPro-death factorsPro-apoptotic factorsNeurodegenerative diseasesVesicular traffickingSpecialized proteinsRegulator proteinMembrane permeabilizationCell stressBioenergetic efficiencyHigh metabolic demandsNeurodegenerative stimuliProteinNormal neuronal activityChannel activityNeuronal functionGenetic mutationsSuch protective strategiesNeuroprotective strategiesNeuronal death
2011
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential
Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal Of Cell Biology 2011, 195: 263-276. PMID: 21987637, PMCID: PMC3198165, DOI: 10.1083/jcb.201108059.Peer-Reviewed Original ResearchConceptsMitochondrial membrane potentialMitochondrial membraneMitochondrial ATP synthase β-subunitATP synthase β subunitBcl-2 family proteinsOuter membrane permeabilizationInner mitochondrial membrane potentialMembrane potentialMitochondrial energetic capacityOuter mitochondrial membraneSynthase β subunitInner mitochondrial membraneInner membrane potentialATP synthaseFamily proteinsBiochemical approachesGenetic evidenceEndogenous BclMembrane permeabilizationCellular resourcesΒ-subunitBcl-xLMitochondrial energeticsEnergetic capacityMitochondrial cristae