2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllergensArachisChildEpitopesFood HypersensitivityHumansImmunoglobulin AInfantPeanut HypersensitivityConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildren
2021
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challenge
2020
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization
Zhang B, Liu E, Gertie JA, Joseph J, Xu L, Pinker EY, Waizman DA, Catanzaro J, Hamza KH, Lahl K, Gowthaman U, Eisenbarth SC. Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization. Science Immunology 2020, 5 PMID: 32385053, PMCID: PMC8518330, DOI: 10.1126/sciimmunol.aay2754.Peer-Reviewed Original ResearchMeSH KeywordsAllergensAnimalsFemaleImmunoglobulin AImmunoglobulin EMaleMiceMice, Inbred C57BLMice, KnockoutPeanut HypersensitivityT-Lymphocytes, Helper-InducerConceptsFood antigensIgE productionIgA productionFollicular helper cellsMinority of miceHelper cell requirementDominant antibody isotypeCross-reactive IgAFollicular regulatoryDietary antigensAllergic sensitizationTolerogenic responsesMucosal adjuvantMucosal IgAHelper cellsAntibody isotypesStool samplesImmunoglobulin AT cellsFood exposureGerminal centersFood allergensAntibody productionIgADietary exposure