2024
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellsCytotoxic CD8<sup>+</sup> T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's <i>t</i> testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c mice
2023
Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model
Kuhn T, Kahl V, Wang Y, Berz A, Shewarega A, Santana J, Antoch G, Chapiro J, Schlachter T, Madoff D. Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model. Journal Of Vascular And Interventional Radiology 2023, 34: 2162-2172.e2. PMID: 37634850, DOI: 10.1016/j.jvir.2023.08.024.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationLiver remnantCirrhotic liverStandardized future liver remnantNon-cirrhotic groupImmune cell infiltrationNon-cirrhotic liverN-butyl cyanoacrylateT-testFemale Yorkshire pigsLarge animal modelLarge animal studiesStudent's t-testCirrhotic groupEmbolized lobeBaseline percentageHepatic hypertrophyCell infiltrationBaseline CTKi-67Preclinical studiesInstitutional Animal CareFLR increase
2022
Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study.
Iseke S, Zeevi T, Kucukkaya AS, Raju R, Gross M, Haider SP, Petukhova-Greenstein A, Kuhn TN, Lin M, Nowak M, Cooper K, Thomas E, Weber MA, Madoff DC, Staib L, Batra R, Chapiro J. Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study. American Journal Of Roentgenology 2022, 220: 245-255. PMID: 35975886, PMCID: PMC10015590, DOI: 10.2214/ajr.22.28077.Peer-Reviewed Original ResearchConceptsEarly-stage hepatocellular carcinomaLiver transplantHepatocellular carcinomaImaging featuresPosttreatment recurrenceOrgan allocationMean AUCLiver transplant eligibilityPretreatment clinical characteristicsPretreatment MRI examinationsKaplan-Meier analysisKaplan-Meier curvesClinical characteristicsImaging surveillanceTherapy allocationTransplant eligibilityUnderwent treatmentClinical parametersRetrospective studyUnpredictable complicationMRI dataConcept studyPoor survivalClinical impactPretreatment MRIBronchial artery embolization for hemoptysis in a postpartum patient via cesarean section with COVID-19 while on extracorporeal membrane oxygenation
Lee M, Cornman-Homonoff J, Madoff DC. Bronchial artery embolization for hemoptysis in a postpartum patient via cesarean section with COVID-19 while on extracorporeal membrane oxygenation. Clinical Imaging 2022, 83: 123-130. PMID: 35033849, PMCID: PMC8743280, DOI: 10.1016/j.clinimag.2021.12.017.Peer-Reviewed Case Reports and Technical Notes
2021
Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma
Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma. Clinical Imaging 2021, 76: 123-129. PMID: 33592550, PMCID: PMC8217099, DOI: 10.1016/j.clinimag.2021.01.043.Peer-Reviewed Original ResearchConceptsOverall survivalTransarterial chemoembolizationHepatocellular carcinomaThermal ablationTA groupEarly-stage hepatocellular carcinomaMedian overall survivalTherapy-naïve patientsKaplan-Meier analysisMaximum tumor diameterStage hepatocellular carcinomaLog-rank testDrug-eluting beadsSmall hepatocellular carcinomaTerms of TTPHIPAA-compliant IRBSignificant differencesLipiodol-TACELocoregional therapyBCLC stageComplication rateTreatment cohortsTumor diameterAFP levelsPatient group
2020
Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses?
LaRussa S, Vanden Berg RW, Craig KM, Madoff DC, McClure TD. Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses? CardioVascular And Interventional Radiology 2020, 43: 1468-1473. PMID: 32613266, DOI: 10.1007/s00270-020-02568-5.Peer-Reviewed Original ResearchConceptsLarge renal massTransarterial embolizationRenal tumorsRenal massesMicrowave ablationCharleston Comorbidity IndexLarge renal tumorsEvidence of recurrencePost-procedure complicationsAverage tumor sizeSelective transarterial embolizationSmall renal tumorsClear cell carcinomaMeeting inclusion criteriaPatient demographic informationGroin hematomaComorbidity indexResultsEleven patientsAverage BMICase seriesSuccessful ablationTumor sizeCell carcinomaMean ageRENAL scoreQuality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis
Kahn S, Julian J, Kearon C, Gu C, Cohen D, Magnuson E, Comerota A, Goldhaber S, Jaff M, Razavi M, Kindzelski A, Schneider J, Kim P, Chaer R, Sista A, McLafferty R, Kaufman J, Wible B, Blinder M, Vedantham S, Sichlau M, Vlahos A, Smith S, Thalheimer Q, Singh N, Harting R, Gocke J, Guth S, Shah N, Brady P, Schatz M, Horrow M, Markazi P, Forouzan L, Matalon T, Hertzog D, Goday S, Kennedy M, Kaplan R, Campbell T, Hartman J, Nahum E, Venkat A, Krishnamurthy V, Rectenwald J, Henke P, Eliason J, Willatt J, Escobar G, Samuels S, Katzen B, Benenati J, Powell A, Pena C, Wallach H, Gandhi R, Schneider J, Kim S, Hashemi F, Boyle J, Patel N, Verta M, Leung D, Garcia M, Blatt P, Khatri J, Epstein D, Ryan R, Sweeny T, Stillabower M, Kimbiris G, Raman T, Sierzenski P, Getto L, Dignazio M, Sierzenski P, Horvath M, Gornik H, Bartholomew J, Shishehbor M, Peacock F, Joseph D, Kim S, Mahlay N, Clair D, Lyden S, Kapoor B, McLennon G, Pierce G, Newman J, Spain J, Gill A, Hamilton A, Rizzo A, Park W, Dietzek A, Galin I, Plummer D, Hsu R, Broderick P, Keller A, Sayeed S, Slater D, Lustberg H, Akus J, Sidman R, Dhami M, Kohanski P, Bulgaru A, Dulala R, Burch J, Kapur D, Yang J, Ranson M, Wladis A, Varnagy D, Mekhail T, Winter R, Perez-Izquierdo M, Motew S, Royd-Kranis R, Workman R, Kribbs S, Hogsette G, Moore P, Thomason B, Means W, Bonsall R, Stewart J, Golwya D, Azene E, Bottner W, Bishop W, Clayton D, Gundersen L, Riherd J, Shakhnovich I, Ziegelbein K, Chang T, Sharma K, Allison S, Banovac F, Cohen E, Furlong B, Kessler C, McCullough M, Spies J, Lin J, Kaatz S, Getzen T, Miller J, Schwartz S, Kabbani L, McVinnie D, Rundback J, Manno J, Schwab R, Cole R, Herman K, Singh D, Barkama R, Patel A, Comerota A, Pigott J, Seiwert A, Whalen R, Russell T, Assi Z, Kazanjian S, Yobbagy J, Kaminski B, Kaufman A, Begeman G, DiSalle R, Thakur S, Kim P, Jacquet M, Dykes T, Gerding J, Baker C, Debiasto M, Mittleider D, Higgins G, Amberson S, Pezzuti R, Gallagher T, Schainfeld R, Wicky S, Kalva S, Walker G, Salazar G, Pomerantz B, Patel V, Kabrhel C, Iqbal S, Gangull S, Oklu R, Brannan S, Misra S, Bjarnason H, Ashrani A, Caccavale M, Fleming C, Friese J, Heit J, Kalra M, Macedo T, McBane R, McKusick M, Stockland A, Woodrum D, Wysokinski W, Verma A, Davis A, Chung J, Nicker D, Anderson B, Stein R, Weiss M, Patel P, Rilling W, Tutton S, Hieb R, Hohenwalter E, Colella M, Gosset J, White S, Lewis B, Brown K, Rossi P, Seabrook G, Guimaraes M, Selby J, McGary W, Hannegan C, Robison J, Brothers T, Elliott B, Garg N, Anderson M, Uflacker R, Schonholz C, Raney L, Greenberg C, Kaufman J, Keller F, Kolbeck K, Landry G, Mitchell E, Barton R, DeLoughery T, Kalbfleisch N, Minjarez R, Lakin P, Liem T, Moneta G, Farsad K, Fleischman R, French L, Marques V, Al−Hassani Y, Sawar A, Taylor F, Patel R, Malhotra R, Kim D, Hashemi F, Boyle J, Patel R, Padnick M, Gurley M, Cucher F, Sterrenberg R, Deepthi G, Cumaranatunge G, Bhatla S, Jacobs D, Dolen E, Gamboa P, Dean L, Davis T, Lippert J, Khanna S, Schirf B, Silber J, Wood D, McGraw J, LaPerna L, Willette P, Murphy T, Cerezo J, Dhangana R, Ahn S, Dubel G, Haas R, Jay B, Prince E, Soares G, Klinger J, Lambiase R, Jay G, Tubbs R, Beland M, Hampson C, O'Hara R, Thompson C, Beland M, Frodsham A, Gardiner F, Jaffan A, Keating L, Zafar A, Alicic R, Raabe R, Brower J, McClellan D, Pellow T, Zylak C, Davis J, Reilly M, Symington K, Seibold C, Nachreiner R, Murray D, Murray S, Saha S, Luna G, Hodgson K, McLafferty R, Hood D, Moore C, Griffen D, Hurst D, Lubbers D, Kim K, Warren B, Engel J, Suresh D, VanderWoude E, Razdan R, Hutchins M, Rounsborg T, Midathada M, Moravec D, Tilford J, Kim D, Beckman J, Razavi M, Openshaw K, Flanigan D, Loh C, Dorne H, Chan M, Thomas J, Psaila J, Ringold M, Fisher J, Lipcomb A, Oskin T, Wible B, Coleman B, Elliott D, Gaddis G, Cochran C, Natarajan K, Bick S, Cooke J, Hedderman A, Greist A, Miller L, Martinez B, Flanders V, Underhill M, Hofmann L, Sze D, Kuo W, Louie J, Hwang G, Hovsepian D, Kothary N, Berube C, Schreiber D, Jeffrey B, Schor J, Deitch J, Singh K, Hahn B, Ardolic B, Gupta S, Bashir R, Rao A, Garg M, Patil P, Zack C, Cohen G, Schmieder F, Lakhter V, Sacks D, Guay R, Scott M, Cunningham K, Sigal A, Cescon T, Leasure N, Dhurairaj T, Muck P, Knochel K, Lohr J, Barreau J, Recht M, Bhaskaran J, Brahmamdam R, Draper D, Mehta A, Maher J, Sharafuddin M, Lentz S, Nugent A, Sharp W, Kresowik T, Nicholson R, Sun S, Youness F, Pascarella L, Ray C, Knuttinen M, Bui J, Gaba R, Dobiesz V, Shamim E, Nimmagadda S, Peace D, Zain A, Palumto A, Haskal Z, Hirshon J, Richard H, Verceles A, Wong-You-Chong J, Othee B, Patel R, Iliescu B, Williams D, Gemmete J, Krishnamurthy V, Cwikiel W, Cho K, Schields J, Vellody R, Novelli P, Dasika N, Wakefield T, Rectenwald J, Henke P, Desmond J, Froehlich J, Khaja M, Hunter D, Golzarian J, Cressman E, Dotta Y, Schmiechen N, Marek J, Garcia D, Tawil I, Langsfeld M, Moll S, Mauro M, Stavas J, Burke C, Dixon R, Yu H, Keagy B, Kim K, Kasthuri R, Key N, Chaer R, Makaroun M, Rhee R, Cho J, Baril D, Marone L, Hseih M, Feterik K, Smith R, Jeyabalan G, Rogers J, Vinik R, Kinikini D, Kraiss L, Mueller M, Pendleton R, Rondina M, Sarfati M, Wanner N, Johnson S, Hopkins C, Ihnat D, Angle J, Matsumoto A, Harthun N, Turba U, Saad W, Uthlaut B, Nannapaneni S, Ling D, Sabri S, Kern J, Macik B, Hoke G, Park A, Stone J, Sneed B, Syverud S, Davidson K, Sharma A, Haskal Z, Wilkins L, Black C, Asay M, Hatch D, Smilanich R, Patten C, Brown S, Nielsen R, Alward W, Collins J, Nokes M, Geary R, Edwards M, Godshall C, Levy P, Winokur R, Sista A, Madoff D, Lee K, Pua B, DeSancho M, Milizia R, Gao J, Goday S, Kennedy M, Kaplan R, Campbell T, McLean G, Hartman J, Nahum E, Khalid S, Vedantham S, Lewis L, Saad N, Thoelke M, Pallow R, Klein S, Sicard G, Cohen D, Comerota A, Gornik H, Jaff M, Julian J, Kahn S, Kearon C, Kee S, Kindzelski A, Lewis L, Magnuson E, Razavi M, Murphy T, Vedantham S. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2020, 8: 8-23.e18. PMID: 31843251, PMCID: PMC7681916, DOI: 10.1016/j.jvsv.2019.03.023.Peer-Reviewed Original ResearchConceptsPharmacomechanical catheter-directed thrombolysisProximal deep venous thrombosisDeep venous thrombosisQuality of lifeDisease-specific QOLIliofemoral deep venous thrombosisCatheter-directed thrombolysisPhysical component summaryVenous thrombosisPCDT groupChange scoresDVT patientsQOL measuresForm Health Survey Physical Component SummaryExtent of DVTLong-term QOLAssessor-blinded randomized trialGeneral QOL measuresVenous Insufficiency EpidemiologicalAcute venous thrombosisDisease-specific QOL measuresGreater improvementThrombolysis trialsCommon femoralComponent summary
2019
Applications of transcatheter embolotherapy in preparation for liver transplantation and resection
Lin EY, Cornman-Homonoff J, Odisio BC, Madoff DC. Applications of transcatheter embolotherapy in preparation for liver transplantation and resection. Chinese Clinical Oncology 2019, 8: 59. PMID: 31865716, DOI: 10.21037/cco.2019.12.03.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLocoregional therapyPost-resection outcomesLiver-directed therapiesAppropriate patient selectionEarly-stage diseasePre-operative periodMaximal potential benefitTranscatheter embolotherapyLiver transplantationPatient selectionSurgical interventionInterventional radiologyPartial hepatectomyTransplantationTherapyPotential benefitsResectionPatientsSurgeryEmbolotherapyHepatectomyDiseaseInterventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.
Fine GC, Smith TA, Stein SI, Madoff DC. Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma. Chinese Clinical Oncology 2019, 8: 40. PMID: 31431037, DOI: 10.21037/cco.2019.07.09.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationManagement of patientsGallbladder carcinomaAggressive biliary tract malignancyInterventional radiology’s roleLate disease statesPortal vein embolizationPost-operative complicationsBiliary tract malignancyCommon gastrointestinal malignancyBile leakGastrointestinal malignanciesSurgical candidatesVein embolizationBiliary drainageBiliary obstructionChronic painPorcelain gallbladderPercutaneous imageRisk factorsInterventional radiologistsPatientsCarcinomaTissue samplingDisease statesExtrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience
Sundararajan SH, McClure TD, Winokur RS, Kishore SA, Madoff DC. Extrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience. Journal Of Vascular And Interventional Radiology 2019, 30: 1021-1026. PMID: 31003843, DOI: 10.1016/j.jvir.2018.11.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAneurysm, FalseCarcinoma, Renal CellComputed Tomography AngiographyEmbolization, TherapeuticFemaleGastrointestinal HemorrhageHumansImaging, Three-DimensionalKidney NeoplasmsMaleMesenteric Artery, SuperiorPancreaticoduodenectomyPostoperative HemorrhagePredictive Value of TestsPreliminary DataProstateProstatic HyperplasiaRadiographic Image Interpretation, Computer-AssistedRadiography, InterventionalRenal ArteryRetrospective StudiesSoftwareTreatment Outcome
2018
Percutaneous Cryoablation for the Management of Chronic Pain Secondary to Locally Recurrent Rectal Cancer with Bowel and Nerve Root Involvement
Cornman-Homonoff J, Formenti SC, Chachoua A, Madoff DC. Percutaneous Cryoablation for the Management of Chronic Pain Secondary to Locally Recurrent Rectal Cancer with Bowel and Nerve Root Involvement. Journal Of Vascular And Interventional Radiology 2018, 29: 1296-1298. PMID: 30146202, DOI: 10.1016/j.jvir.2018.02.022.Peer-Reviewed Case Reports and Technical Notes
2017
Multicenter Trial of the VenaTech Convertible Vena Cava Filter
Hohenwalter EJ, Stone JR, O’Moore P, Smith SJ, Selby JB, Lewandowski RJ, Samuels S, Kiproff PM, Trost DW, Madoff DC, Handel J, Gandras EJ, Vlahos A, Rilling WS. Multicenter Trial of the VenaTech Convertible Vena Cava Filter. Journal Of Vascular And Interventional Radiology 2017, 28: 1353-1362. PMID: 28821379, DOI: 10.1016/j.jvir.2017.06.032.Peer-Reviewed Original ResearchConceptsVena cava filtersCava filtersDevice-related adverse eventsHigh-risk traumaAdverse event ratesSingle-arm studyFailure of anticoagulationTechnical success rateLong-term safetyConverted patientsAdverse eventsPulmonary embolismSurgical prophylaxisVenous thromboembolismMulticenter trialCaval filtersRight atriumSurgical removalClinical assessmentProcedure timePatientsEvent ratesMean timeSuccess rateMonthsCatheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis.
Lee KS, Santagostino SF, Li D, Ramjit A, Serrano K, Ginsberg MD, Ding BS, Rafii S, Madoff DC. Catheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis. Radiology 2017, 285: 114-123. PMID: 28498793, DOI: 10.1148/radiol.2017162617.Peer-Reviewed Original ResearchConceptsEndothelial cell therapyMean proliferation indexLiver endothelial cellsCell therapyEndothelial cellsIntraportal deliveryProliferation indexPorcine modelCatheter-directed deliveryTreatment of cirrhosisInduction of cirrhosisMasson's trichrome stainingUnpaired t-testLarge animal studiesAutologous cell therapyHepatic specimensHepatobiliary injuryTranscatheter infusionHepatic arteryFluorescence-activated cellPathologic examinationHepatic fibrosisDuctal damageLiver fibrosisSurrogate marker
2014
Characterization of In Vivo Ablation Zones Following Percutaneous Microwave Ablation of the Liver with Two Commercially Available Devices: Are Manufacturer Published Reference Values Useful?
Winokur RS, Du JY, Pua BB, Talenfeld AD, Sista AK, Schiffman MA, Trost DW, Madoff DC. Characterization of In Vivo Ablation Zones Following Percutaneous Microwave Ablation of the Liver with Two Commercially Available Devices: Are Manufacturer Published Reference Values Useful? Journal Of Vascular And Interventional Radiology 2014, 25: 1939-1946.e1. PMID: 25307296, DOI: 10.1016/j.jvir.2014.08.014.Peer-Reviewed Original ResearchBland embolization versus chemoembolization of hepatocellular carcinoma before transplantation
Kluger MD, Halazun KJ, Barroso RT, Fox AN, Olsen SK, Madoff DC, Siegel AB, Weintraub JL, Sussman J, Brown RS, Cherqui D, Emond JC. Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation. Liver Transplantation 2014, 20: 536-543. PMID: 24493271, PMCID: PMC4095977, DOI: 10.1002/lt.23846.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, HepatocellularCase-Control StudiesChemoembolization, TherapeuticDisease-Free SurvivalEnd Stage Liver DiseaseFemaleHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTime FactorsTreatment OutcomeConceptsWait-list dropoutTAE patientsTACE patientsTransarterial embolizationTransarterial chemoembolizationHCC patientsEnd-stage liver disease (MELD) scoreSurvival rateRecurrence-free survival ratesMethods of embolizationRadiographic tumor sizeLiver Disease scoreOverall survival rateRecurrence-free survivalKaplan-Meier survivalBland transarterial embolizationCase-control studySignificant demographic differencesExplant tumorsPrimary endpointTreat basisTumor sizeHepatocellular carcinomaDisease scorePatients
2011
Phase I Trial of Hepatic Arterial Infusion of Nanoparticle Albumin–Bound Paclitaxel: Toxicity, Pharmacokinetics, and Activity
Fu S, Naing A, Moulder SL, Culotta KS, Madoff DC, Ng CS, Madden TL, Falchook GS, Hong DS, Kurzrock R. Phase I Trial of Hepatic Arterial Infusion of Nanoparticle Albumin–Bound Paclitaxel: Toxicity, Pharmacokinetics, and Activity. Molecular Cancer Therapeutics 2011, 10: 1300-1307. PMID: 21571911, DOI: 10.1158/1535-7163.mct-11-0259.Peer-Reviewed Original ResearchConceptsHepatic arterial infusionNab-paclitaxelHepatic extractionArterial infusionDose levelsNanoparticle Albumin-Bound PaclitaxelFirst-pass hepatic extractionPredominant liver metastasesCommon adverse eventsAdvanced cancer patientsAlbumin-Bound PaclitaxelDose-limiting toxicityPeak concentrationHighest dose levelStable diseaseAdverse eventsLiver involvementLiver metastasesPartial responseI trialComparative pharmacokinetic studyHepatic metastasesPoor outcomeCancer patientsNanoparticle albuminHigh Survival Rate After Two-Stage Resection of Advanced Colorectal Liver Metastases: Response-Based Selection and Complete Resection Define Outcome
Brouquet A, Abdalla EK, Kopetz S, Garrett CR, Overman MJ, Eng C, Andreou A, Loyer EM, Madoff DC, Curley SA, Vauthey JN. High Survival Rate After Two-Stage Resection of Advanced Colorectal Liver Metastases: Response-Based Selection and Complete Resection Define Outcome. Journal Of Clinical Oncology 2011, 29: 1083-1090. PMID: 21263087, PMCID: PMC3068054, DOI: 10.1200/jco.2010.32.6132.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic AgentsChemotherapy, AdjuvantColorectal NeoplasmsFemaleHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedNeoadjuvant TherapyPatient SelectionRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTexasTime FactorsTomography, X-Ray ComputedTreatment OutcomeConceptsAdvanced colorectal liver metastasesTwo-stage resectionColorectal liver metastasesLiver metastasesComplete resectionSurvival rateMedical groupMajor postoperative complicationsSurvival of patientsChemotherapy initiationNonsurgical patientsOnly chemotherapyPostoperative complicationsColorectal metastasesMetastatic diseaseObjective responseWorse survivalTreat analysisGood respondersExcellent outcomesTSR groupInclusion criteriaResectionPatientsChemotherapy
2010
Response, Survival, and Prognostic Factors After Hepatic Arterial Chemoembolization in Patients With Liver Metastases From Cutaneous Melanoma
Ahrar J, Gupta S, Ensor J, Ahrar K, Madoff DC, Wallace MJ, Murthy R, Tam A, Hwu P, Bedikian AY. Response, Survival, and Prognostic Factors After Hepatic Arterial Chemoembolization in Patients With Liver Metastases From Cutaneous Melanoma. Cancer Investigation 2010, 29: 49-55. PMID: 21166498, DOI: 10.3109/07357907.2010.535052.Peer-Reviewed Original ResearchConceptsHepatic artery chemoembolizationOverall survivalCutaneous melanoma metastaticExtrahepatic metastatic sitesHepatic arterial chemoembolizationMedian overall survivalLactate dehydrogenase levelsType of treatmentMelanoma metastaticRadiologic responseDisease stabilizationLiver metastasesMost patientsPatient ageArterial chemoembolizationPrognostic factorsLiver diseaseMetastatic sitesCutaneous melanomaMedical recordsDehydrogenase levelsPatientsSignificant predictorsChemoembolizationSurvivalExploratory Study of Hepatic Arterial Infusion Oxaliplatin With Systemic 5-Fluorouracil/Bevacizumab in Patients With Refractory Solid Tumor and Extensive Liver Metastases
Camacho LH, Garcia S, Panchal AM, Lim J, Hong DS, Ng C, Madoff DC, Fu S, Gayed I, Kurzrock R. Exploratory Study of Hepatic Arterial Infusion Oxaliplatin With Systemic 5-Fluorouracil/Bevacizumab in Patients With Refractory Solid Tumor and Extensive Liver Metastases. Clinical Colorectal Cancer 2010, 9: 311-314. PMID: 21208846, PMCID: PMC3088086, DOI: 10.3816/ccc.2010.n.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBevacizumabColorectal NeoplasmsDrug Resistance, NeoplasmFemaleFluorouracilHepatic ArteryHumansInfusions, Intra-ArterialLeucovorinLiver NeoplasmsMaleMiddle AgedOrganoplatinum CompoundsOvarian NeoplasmsOxaliplatinPilot ProjectsSalvage TherapySurvival RateTomography, X-Ray ComputedTreatment OutcomeConceptsExtensive liver metastasesRefractory solid tumorsLiver metastasesTotal bilirubinSolid tumorsBaseline serum total bilirubinHepatic arterial infusion (HAI) oxaliplatinMedian Child-Pugh scoreAdvanced refractory malignanciesGrade 1 fatigueMedian total bilirubinRegional hepatic therapySystemic anticancer agentsChild-Pugh scoreCommon side effectsSerum total bilirubinPilot clinical trialElevated bilirubinLiver involvementPartial responseHepatic insufficiencyMedian ageRefractory malignanciesClinical trialsDisease progressionHepatic Artery Chemoembolization in Patients With Ocular Melanoma Metastatic to the Liver
Gupta S, Bedikian AY, Ahrar J, Ensor J, Ahrar K, Madoff DC, Wallace MJ, Murthy R, Tam A, Hwu P. Hepatic Artery Chemoembolization in Patients With Ocular Melanoma Metastatic to the Liver. American Journal Of Clinical Oncology 2010, 33: 474-480. PMID: 19935383, DOI: 10.1097/coc.0b013e3181b4b065.Peer-Reviewed Original ResearchConceptsHepatic arterial chemoembolizationOcular melanoma metastaticProgression-free survival durationMedian OS durationOverall survivalLactate dehydrogenase levelsMelanoma metastaticRadiologic responseLiver involvementSurvival durationOS durationDehydrogenase levelsResponse rateBaseline lactate dehydrogenase levelsHigher lactate dehydrogenase levelsMedian overall survivalTumor response rateHepatic artery chemoembolizationShorter overall survivalStable diseaseDisease stabilizationProgressive diseaseArterial chemoembolizationMost patientsPartial response