2019
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAge FactorsAgedAged, 80 and overAgingAnimalsAntioxidantsApoptosisBiomarkersBlood PlateletsCardiovascular DiseasesComorbidityDisease Models, AnimalFemaleHomeostasisHumansMaleMiceMiddle AgedOxidation-ReductionOxidative StressPlatelet ActivationPlatelet AdhesivenessReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsRisk patientsMouse studiesPlatelet phenotypeMajor adverse cardiovascular eventsHigh cardiovascular risk patientsAdaptive increaseAdverse cardiovascular eventsCentral pathophysiological roleCVD risk patientsCardiovascular risk patientsAggressive antiplatelet therapyEffect of comorbidityAge group 40Young healthy subjectsAntiplatelet therapyCardiovascular eventsYear age cohortAdvanced ageCVD patientsGroup 40Healthy subjectsPathophysiological roleElderly populationCardiovascular pathologyPatients
2010
Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction.
Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPercutaneous coronary interventionReperfusion therapyMyocardial infarctionOutcome of nonagenariansMedical therapy groupAcute coronary syndromeMajority of patientsKaplan-Meier analysisProcedure-associated complicationsTreatment of patientsYears of ageHospital mortalityPCI groupCoronary syndromeCoronary interventionHospital dischargeOlder patientsSurvival benefitBetter prognosisCurrent guidelinesTherapy groupLower incidenceRetrospective analysisPatientsLong-term Outcome of Tako-tsubo Cardiomyopathy
Ionescu CN, Aguilar-Lopez CA, Sakr AE, Ghantous AE, Donohue TJ. Long-term Outcome of Tako-tsubo Cardiomyopathy. Heart Lung And Circulation 2010, 19: 601-605. PMID: 20655278, DOI: 10.1016/j.hlc.2010.06.667.Peer-Reviewed Original ResearchConceptsTako-tsubo cardiomyopathyLong-term outcomesMyocardial Infarction (TIMI) myocardial perfusion gradeCombined end pointMyocardial perfusion gradeLeft heart catheterisationSudden cardiac deathCardiac reasonsCardiogenic shockHeart catheterisationCardiac deathPerfusion gradeMean agePrognostic implicationsExcellent outcomesRetrospective analysisCaucasian femalePatientsEnd pointOutcomesFive-year periodCardiomyopathyTMPGStressor eventsCurrent data