2024
Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform
Costello R, Waller K, Smith R, Mells G, Wong A, Schultze A, Mahalingasivam V, Herrett E, Zheng B, Lin L, MacKenna B, Mehrkar A, Bacon S, Goldacre B, Tomlinson L, Tazare J, Rentsch C. Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform. Communications Medicine 2024, 4: 238. PMID: 39562612, PMCID: PMC11576861, DOI: 10.1038/s43856-024-00664-y.Peer-Reviewed Original ResearchCOVID-19 hospitalisationSevere COVID-19 outcomesCOVID-19 related hospitalisationCOVID-19 outcomesCohort studyPopulation-based cohort studyHazard ratioPrimary care recordsDeath registration dataOpenSAFELY-TPP platformApproval of NHS EnglandConfidence intervalsEstimate hazard ratiosCox proportional hazards regressionProportional hazards regressionPre-specified confoundersAbsolute risk reductionOpenSAFELY platformCare recordsNHS EnglandConfounder adjustmentEligible individualsRegistration dataHazards regressionHospital records
2021
Statin exposure and risk of cancer in people with and without HIV infection.
Bedimo RJ, Park LS, Shebl FM, Sigel K, Rentsch CT, Crothers K, Rodriguez-Barradas MC, Goetz MB, Butt AA, Brown ST, Gibert C, Justice AC, Tate JP. Statin exposure and risk of cancer in people with and without HIV infection. AIDS 2021, 35: 325-334. PMID: 33181533, PMCID: PMC7775280, DOI: 10.1097/qad.0000000000002748.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyStatin useStatin exposureHazard ratioCancer riskLower riskPropensity score-matched cohortCox regression hazard ratiosAging Cohort StudyAnti-inflammatory effectsRegression hazard ratiosNon-Hodgkin lymphomaConfidence intervalsCancer registry linkagePropensity score-matched sampleRisk of cancerDeath overallUninfected patientsCohort studyIncident cancerRegistry linkageHIV infectionHIV statusStatin initiatorsUninfected persons
2019
Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States
Rentsch CT, Tate JP, Steel T, Butt AA, Gibert CL, Huang L, Pisani M, Soo Hoo GW, Crystal S, Rodriguez-Barradas MC, Brown ST, Freiberg MS, Graber CJ, Kim JW, Rimland D, Justice AC, Fiellin DA, Crothers KA, Akgün KM. Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 80: 145-151. PMID: 30422912, PMCID: PMC6701630, DOI: 10.1097/qai.0000000000001904.Peer-Reviewed Original ResearchConceptsHepatitis C virusAlcohol-related diagnosesAdmission ratesMICU admissionAdmission riskC virusRelative riskIntensive care unit admission rateMedical intensive care unit admissionAge-adjusted admission ratesHCV mono-infected patientsIntensive care unit admissionVeterans Aging Cohort StudyHCV care providersCare unit admissionAging Cohort StudyAdjusted rate ratiosConfidence intervalsVeterans Health AdministrationUnhealthy alcohol useHIV monoHIV-/HCVUnit admissionCause hospitalizationHCV infection
2018
Viral suppression among persons in HIV care in the United States during 2009–2013: sampling bias in Medical Monitoring Project surveillance estimates
Bradley H, Althoff KN, Buchacz K, Brooks JT, Gill MJ, Horberg MA, Kitahata MM, Marconi V, Mayer KH, Mayor A, Moore R, Mugavero M, Napravnik S, Paz-Bailey G, Prejean J, Rebeiro PF, Rentsch CT, Shouse RL, Silverberg MJ, Sullivan PS, Thorne JE, Yehia B, Rosenberg ES. Viral suppression among persons in HIV care in the United States during 2009–2013: sampling bias in Medical Monitoring Project surveillance estimates. Annals Of Epidemiology 2018, 31: 3-7. PMID: 30529086, PMCID: PMC6420358, DOI: 10.1016/j.annepidem.2018.11.005.Peer-Reviewed Original ResearchConceptsMedical Monitoring ProjectHIV careCare attendanceSurveillance estimatesNorth American AIDS Cohort CollaborationHIV care attendanceMultivariable regression modelsWeighted population estimatesCohort CollaborationVS statusViral suppressionCohort dataNumber of personsConfidence intervalsCareCalendar yearFull calendar yearRegression modelsLast testAttendancePersonsHIVPatientsCareful examination