2022
Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records
Muzambi R, Bhaskaran K, Rentsch C, Smeeth L, Brayne C, Garfield V, Williams D, Chaturvedi N, Warren-Gash C. Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records. Translational Psychiatry 2022, 12: 385. PMID: 36109502, PMCID: PMC9478085, DOI: 10.1038/s41398-022-02145-z.Peer-Reviewed Original ResearchConceptsCognitive declineWhite matter hyperintensity volumeSecondary care recordsAssociation of infectionHistory of infectionPotential structural correlatesEvidence of associationCommon infectionsDementia riskHyperintensity volumeInfection diagnosisCare recordsCognitive impairmentLinear mixed effects modelsCognitive functionVolunteer cohortInfectionMixed effects modelsStructural correlatesUK BiobankLinear regression modelsAssociationEffects modelRegression modelsVisual memory
2021
HbA1c and brain health across the entire glycaemic spectrum
Garfield V, Farmaki A, Eastwood SV, Mathur R, Rentsch CT, Bhaskaran K, Smeeth L, Chaturvedi N. HbA1c and brain health across the entire glycaemic spectrum. Diabetes Obesity And Metabolism 2021, 23: 1140-1149. PMID: 33464682, PMCID: PMC8261644, DOI: 10.1111/dom.14321.Peer-Reviewed Original ResearchConceptsVascular dementiaHippocampal volumeGlycaemic spectrumBrain healthWMH volumeAlzheimer's dementiaAD riskCognitive declineWhite matter hyperintensity volumeIncident vascular dementiaLower WMH volumeHigher WMH volumeGreater hippocampal volumeBrain health outcomesLower hippocampal volumeUK Biobank cohortGlycaemic categoriesKnown diabetesAntihypertensive medicationsHbA1c levelsCause dementiaCertain cardiovascular drugsExcess riskNormoglycaemic individualsHyperintensity volume