2021
Impact of Sex on Sleep Disorders Across the Lifespan
Tobias L, Thapa S, Won CHJ. Impact of Sex on Sleep Disorders Across the Lifespan. Clinics In Chest Medicine 2021, 42: 427-442. PMID: 34353449, DOI: 10.1016/j.ccm.2021.04.005.ChaptersConceptsSleep disordersAdverse maternal outcomesSleep-disordered breathingQuality of lifeImpact of sexDevelopment of insomniaMaternal outcomesMedical comorbiditiesSex predominanceVasomotor symptomsSleep symptomsReproductive milestonesSleep disturbancesSleep architectureSleep disruptionHormonal changesWomen's livesDisordersMenopausePregnancySymptomsComorbiditiesDerangementInsomniaPrevalence
2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factorsTreating Sleep-Related Breathing Disorders
Won C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders. 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.Peer-Reviewed Original ResearchPositive airway pressure therapySignificant symptomatic benefitAirway pressure therapySleep-disordered breathingMental health outcomesNeuropsychomotor functionsPAP therapyMainstay treatmentSymptomatic benefitPAP adherenceBreathing disordersPressure therapySide effectsHealth outcomesPatientsTherapyEffective alternativeAdherenceRobust evidenceTolerabilityBreathingSleep
2017
Impact of Sleep Breathing Disorders in Obese Critically Ill Patients
Al-Halawani M, Won C. Impact of Sleep Breathing Disorders in Obese Critically Ill Patients. 2017, 77-85. DOI: 10.1007/978-3-319-49253-7_8.Peer-Reviewed Original ResearchSleep breathing disordersBreathing disordersObesity hypoventilation syndromeObstructive sleep apneaSleep-disordered breathingIntensive care unitObese patientsHypoventilation syndromeIll patientsCare unitSleep apneaIll populationMajor causeObesePatientsDisordersRiskSerious riskApneaICUMorbidityComplicationsSyndromeMortalityBreathing
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delay
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic controlGender differences in sleep disordered breathing: implications for therapy
Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingSeverity of OSAUpper airway functionGender-related differencesAirway functionEndothelial dysfunctionLung functionComorbid conditionsSleep apneaTreatment optionsRespiratory stabilityImproved outcomesGender differencesGreater riskAdverse effectsWomenLimited dataAge increasesBreathingFemale presentationsHypertensionApneaAirwayPregnancy
2010
Epidemiology of sleep-related complaints associated with sleep-disordered breathing in Bangkok, Thailand
Suwanprathes P, Won C, Komoltri C, Nana A, Kotchabhakdi N, Guilleminault C. Epidemiology of sleep-related complaints associated with sleep-disordered breathing in Bangkok, Thailand. Sleep Medicine 2010, 11: 1025-1030. PMID: 20643577, DOI: 10.1016/j.sleep.2010.04.007.Peer-Reviewed Original ResearchConceptsSleep-related complaintsNight sweatsDaytime sleepinessSleep-disordered breathingExcessive daytime sleepinessFirst epidemiologic studyNocturnal sleep timeHabitual snoringWaist circumferenceSleep disturbancesEndocrine diseasesHealth morbidityMale genderRisk factorsGreater BMIEpidemiologic studiesGreater prevalenceSleep timeSleep InventoryMultivariate analysisThai populationSleepComplaintsSignificant predictorsBMICardiovascular Consequences of Sleep Apnea
Selim B, Won C, Yaggi HK. Cardiovascular Consequences of Sleep Apnea. Clinics In Chest Medicine 2010, 31: 203-220. PMID: 20488282, DOI: 10.1016/j.ccm.2010.02.010.ChaptersConceptsObstructive sleep apneaCardiovascular diseaseSleep apneaTreatment of OSAImportant public health challengeNonfatal cardiovascular eventsSpecific cardiovascular outcomesSleep-disordered breathingCardiovascular health outcomesEpidemic of obesityBurden of diseaseCause of deathGeneral adult populationNovel therapeutic approachesPublic health challengeCardiovascular eventsCardiovascular outcomesCause mortalityCardiovascular consequencesMyocardial ischemiaTherapeutic approachesHealth outcomesAdult populationHealth challengesNovel target