2022
Management of Steroid-Refractory Gastrointestinal Immune-Related Adverse Events
Brongiel S, Rychalsky K, Luon D, Johnson A, Price C, Abdelghany O. Management of Steroid-Refractory Gastrointestinal Immune-Related Adverse Events. Annals Of Pharmacotherapy 2022, 57: 148-155. PMID: 35656843, DOI: 10.1177/10600280221094330.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsInstitutional review boardImmunosuppressive therapyAdverse eventsSymptom resolutionImmune-related adverse eventsSecond-line immunosuppressive therapyRetrospective medical record reviewSecond-line medicationsCommon Terminology CriteriaSecond-line therapySecond-line treatmentMedical record reviewDose of infliximabHigh response rateUniversity Institutional Review BoardGastrointestinal ImmuneIrAE treatmentSteroid failureTerminology CriteriaCheckpoint inhibitorsMost patientsRecord reviewInclusion criteriaPatients
2021
Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose
Krantz MS, Kwah JH, Stone CA, Phillips EJ, Ortega G, Banerji A, Blumenthal KG. Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose. JAMA Internal Medicine 2021, 181: 1530-1533. PMID: 34309623, PMCID: PMC8314170, DOI: 10.1001/jamainternmed.2021.3779.Peer-Reviewed Original ResearchMeSH Keywords2019-nCoV Vaccine mRNA-1273AdultAgedBNT162 VaccineCOVID-19 VaccinesFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsCytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19
Azmy V, Kaman K, Tang D, Zhao H, Dela Cruz C, Topal JE, Malinis M, Price CC. Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19. Journal Of Clinical Immunology 2021, 41: 738-747. PMID: 33459964, PMCID: PMC7812117, DOI: 10.1007/s10875-020-00949-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, Monoclonal, HumanizedBiomarkersCOVID-19COVID-19 Drug TreatmentCytokine Release SyndromeCytokinesDrug Therapy, CombinationFeasibility StudiesFemaleGlucocorticoidsHospitalizationHumansImmunologic FactorsMaleMiddle AgedRetrospective StudiesSARS-CoV-2Severity of Illness IndexTreatment OutcomeYoung AdultConceptsIL-10 levelsIL-6IL-10Disease severityCytokine profileD-dimerTreatment algorithmCritical SARS-CoV-2 infectionCOVID-19SARS-CoV-2 infectionAdministration of tocilizumabAdmission IL-6Maximum oxygen requirementsTocilizumab-treated patientsElevated IL-6Immune-modulating therapyCritical COVID-19Retrospective chart reviewTertiary care centerIL-6 levelsMean IL-6IL-6 inhibitionAdministration of glucocorticoidsRole of cytokinesCytokine elevation