2024
Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort
Nokes B, Orr J, White S, Luu S, Chen Z, Alex R, Sands S, Wojeck B, Owens R, Malhotra A, Schmickl C. Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort. Journal Of Applied Physiology 2024, 136: 1516-1525. PMID: 38660729, PMCID: PMC11368527, DOI: 10.1152/japplphysiol.00925.2023.Peer-Reviewed Original ResearchApnea-hypopnea indexObstructive sleep apneaBody mass indexEffect of body mass indexCirculatory delayArousal thresholdAssociated with apnea-hypopnea indexObstructive sleep apnea risk factorsObstructive Sleep Apnea EndotypesIn-laboratory polysomnographyUpper airway collapseEvents per hourHigh arousal thresholdsEffect of obesityHypopnea indexOSA pathogenesisSleep apneaConsecutive adultsSleep clinicEndotypic traitsAirway collapseMass indexPathogenesis differencesRisk factorsPolysomnography signals
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsLessons Learned From Major Clinical Outcomes Trials Involving Sodium-Glucose Cotransporter 2 Inhibitors.
Wojeck BS, Inzucchi SE. Lessons Learned From Major Clinical Outcomes Trials Involving Sodium-Glucose Cotransporter 2 Inhibitors. Diabetes Spectrum 2021, 34: 235-242. PMID: 34511849, PMCID: PMC8387615, DOI: 10.2337/ds20-0070.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsMajor clinical outcome trialsRecent large clinical trialsDiabetes treatment guidelinesGlucose-lowering medicationsChronic kidney diseaseClinical outcome trialsLarge clinical trialsRenal outcomesOutcome trialsTreatment guidelinesKidney diseaseRisk factorsClinical trialsMedicationsTrialsInhibitorsDiabetesDisease