2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcome
2022
Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort studyNational Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship
Datta R, Fried T, O’Leary J, Zullo AR, Allore H, Han L, Juthani-Mehta M, Cohen A. National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship. Open Forum Infectious Diseases 2022, 9: ofac453. PMID: 36147594, PMCID: PMC9487603, DOI: 10.1093/ofid/ofac453.Peer-Reviewed Original ResearchHome-based primary careDays of therapyAntibiotic use ratesAntibiotic useHomebound personsOverall median lengthPhysician home visitsNational cohort studyAntibiotic prescribing trendsVeterans Health AdministrationUse ratesProvider visitsAntibiotic prescriptionsCohort studyPrescribing trendsTelephone visitsMedian agePrescription fillsMedian lengthAntibiotic stewardshipNational cohortPrimary careHome visitsHealth AdministrationPrescribed class
2021
Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization data
2020
Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes
Cohen AB, Han L, OʼLeary JR, Fried TR. Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes. Journal Of The American Geriatrics Society 2020, 69: 342-348. PMID: 33170957, PMCID: PMC7902349, DOI: 10.1111/jgs.16900.Peer-Reviewed Original ResearchConceptsDays of lifeHospital deathHigh-intensity treatmentMechanical ventilationTube placementHome residentsCardiopulmonary resuscitationNursing homesIntensive care unit admissionMinimum Data Set assessmentsCare unit admissionRetrospective cohort studyNursing home residentsHigh-intensity endMore nursing homesUnit admissionICU admissionCohort studySecondary outcomesPrimary outcomeHospital transferLife hospitalizationsSevere dementiaLife careDementia severity
2019
End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians
Cohen AB, Benjamin AZ, Fried TR. End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians. Journal Of The American Geriatrics Society 2019, 67: 2161-2166. PMID: 31301189, PMCID: PMC6800801, DOI: 10.1111/jgs.16072.Peer-Reviewed Original ResearchConceptsHigh-intensity treatmentPatient preferencesHospice careVeterans Affairs Connecticut Healthcare SystemUnderwent cardiopulmonary resuscitationRetrospective cohort studyIntensive care unitLast monthAdvance care planningLife decisionsDecedent patientsLife decision makingChart reviewCohort studyCare unitTreatment outcomesCardiopulmonary resuscitationOutpatient facilitiesLife careCare planningVA recordsVA facilitiesProfessional guardiansPatientsOlder adults
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic disease
2011
Comparative Effectiveness of Aminoglycosides, Polymyxin B, and Tigecycline for Clearance of Carbapenem-Resistant Klebsiella pneumoniae from Urine
Satlin MJ, Kubin CJ, Blumenthal JS, Cohen AB, Furuya EY, Wilson SJ, Jenkins SG, Calfee DP. Comparative Effectiveness of Aminoglycosides, Polymyxin B, and Tigecycline for Clearance of Carbapenem-Resistant Klebsiella pneumoniae from Urine. Antimicrobial Agents And Chemotherapy 2011, 55: 5893-5899. PMID: 21968368, PMCID: PMC3232750, DOI: 10.1128/aac.00387-11.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAminoglycosidesAnti-Bacterial AgentsCarbapenemsCohort StudiesDrug Resistance, BacterialFemaleHumansKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsMiddle AgedMinocyclinePolymyxin BRetrospective StudiesTigecyclineTreatment OutcomeUrinary Tract InfectionsUrineYoung AdultConceptsCarbapenem-resistant Klebsiella pneumoniaePolymyxin BCRKP bacteriuriaMicrobiologic clearanceUntreated cohortHealth care-associated urinary tract infectionsClearance rateKlebsiella pneumoniaeRetrospective cohort studyUrinary tract infectionNew York Presbyterian HospitalCohort studyTract infectionsUrine cultureAntimicrobial therapyAppropriate followCommon causeActive agentsMultiple active agentsTigecyclineComparative effectivenessMultivariate analysisCohortGram-negative activityAminoglycosides