Localized Changes in the gp120 Envelope Glycoprotein Confer Resistance to Human Immunodeficiency Virus Entry Inhibitors BMS-806 and #155
Madani N, Perdigoto AL, Srinivasan K, Cox JM, Chruma JJ, LaLonde J, Head M, Smith AB, Sodroski JG. Localized Changes in the gp120 Envelope Glycoprotein Confer Resistance to Human Immunodeficiency Virus Entry Inhibitors BMS-806 and #155. Journal Of Virology 2004, 78: 3742-3752. PMID: 15016894, PMCID: PMC371073, DOI: 10.1128/jvi.78.7.3742-3752.2004.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsAnti-HIV AgentsCell LineDogsDrug Resistance, ViralHIV Envelope Protein gp120HIV-1HumansModels, MolecularPhenylalaninePiperazinesProtein Structure, TertiaryConceptsBMS-806Envelope glycoproteinHuman immunodeficiency virus type 1 (HIV-1) entryGp41 transmembrane envelope glycoproteinGp120 exterior envelope glycoproteinHIV-1 envelope glycoproteinExterior envelope glycoproteinPhe 43 cavityV2 variable loopsCD4-bound conformationTransmembrane envelope glycoproteinHost cell receptorsAntiviral effectCD4 bindingReceptor-binding regionCell receptorReceptor bindingBind gp120Mode of actionGp120Glycoprotein mutantsDrugsNovel inhibitorsGlycoproteinConfer resistance