2022
Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV
Titanji BK, Lee M, Wang Z, Chen J, Hui Q, Re V, So-Armah K, Justice AC, Xu K, Freiberg M, Gwinn M, Marconi VC, Sun YV. Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV. Frontiers In Genetics 2022, 13: 1020871. PMID: 36303554, PMCID: PMC9592923, DOI: 10.3389/fgene.2022.1020871.Peer-Reviewed Original ResearchLiver diseaseLiver biomarkersLiver functionDNAm age accelerationAge accelerationVeterans Aging Cohort StudyEpigenome-wide association studiesFIB-4 scoreAging Cohort StudyMale PWHAPRI scoreCohort studyPlatelet countTotal bilirubinAlanine transaminaseClinical dataBlood samplesIndependent cohortSerum albuminMale veteransHIVImportant causeSignificant associationPWHDNAm sites
2018
Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study)
Marconi VC, Duncan MS, So‐Armah K, Re VL, Lim JK, Butt AA, Goetz MB, Rodriguez‐Barradas M, Alcorn CW, Lennox J, Beckman JA, Justice A, Freiberg M. Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study). Journal Of The American Heart Association 2018, 7: e007792. PMID: 29720501, PMCID: PMC6015337, DOI: 10.1161/jaha.117.007792.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal cardiovascular diseaseIschemic stroke eventsCardiovascular diseaseCVD eventsHeart failureMyocardial infarctionTotal bilirubinElevated bilirubinStroke eventsRisk factorsIncident total CVDBaseline total bilirubinBaseline cardiovascular diseaseIncident CVD eventsHIV-negative individualsProspective cohort studyElevated bilirubin levelsMultiple risk factorsCohort studyCVD riskHazard ratioIschemic strokeHIV-positiveBilirubin levels