2018
New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients
Liu Y, Tsatkin V, Fazzone-Chettiar R, Miller E, Sinusas A. New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients. 2018, 00: 1-3. DOI: 10.1109/nssmic.2018.8824749.Peer-Reviewed Original ResearchEnd-diastolic volumeEquilibrium radionuclide angiocardiographyLeft ventricular functionGated blood pool SPECTPeak filling rateBlood pool SPECTEjection fractionVentricular functionRadionuclide angiocardiographyLV end-diastolic volumeHigh-dose injectionLow-dose injectionsAnterior oblique viewSingle photon emissionRed blood cellsDose reductionReduced radiation dosePatientsShort-axis slicesBlood cellsRadiation exposureGold standardImaging modalitiesRadiation doseOblique view
2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake