2021
Novel SPECT and PET Tracers and Myocardial Imaging
Melvinsdottir I, Avendaño R, Sinusas A. Novel SPECT and PET Tracers and Myocardial Imaging. 2021, 189-228. DOI: 10.1007/978-3-030-83167-7_11.Peer-Reviewed Original ResearchPositron emission tomographyPET imagingMultimodality cardiovascular imagingSingle photon emissionRisk stratificationPathophysiological changesCardiac functionMyocardial remodelingMyocardial diseaseAutonomic regulationMyocardial imagingEmission tomographyHigh-resolution anatomicalMyocardial flowCardiovascular imagingPET tracersNovel SPECTMolecular changesSPECTPhoton emissionHybrid imaging technologyCell deathVivo detectionMolecular imagingImaging
2019
Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling
Boutagy N, Feher A, Sikanderkhel S, Sinusas A. Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling. 2019, 405-435. DOI: 10.1002/9781118754467.ch13.ChaptersHeart failureManagement of HFMultimodality cardiovascular imagingMolecular imaging targetsMagnetic resonance imagingPositron emission tomographySingle photon emissionExtracellular matrix depositionCardiac injuryVentricle remodelingVentricular remodelingStandard clinical toolResonance imagingEmission tomographyClinical toolCompensatory mechanismsCardiac perfusionCardiovascular imagingNuclear imaging modalitiesImaging modalitiesImaging targetsPhoton emissionMatrix depositionNoninvasive measurementMolecular imagingMolecular Imaging of the Heart
Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ. Molecular Imaging of the Heart. 2019, 9: 477-533. PMID: 30873600, DOI: 10.1002/cphy.c180007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular diseaseRisk stratificationCardiovascular molecular imagingMultimodality cardiovascular imagingIschemic heart failureMolecular imagingMolecular imaging targetsPositron emission tomographySingle photon emissionNumerous cardiovascular diseasesClinical molecular imagingEjection fractionHeart failureMedical therapySystemic diseaseMyocardial infarctionPathophysiological changesCardiac functionEarly diagnosisDisease processCardiac arrhythmiasEmission tomographyCardiovascular imagingImaging strategiesPhoton emission
2018
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients
Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovascular Imaging 2018, 13: 109-120. PMID: 30343093, PMCID: PMC6461525, DOI: 10.1016/j.jcmg.2018.08.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHeart TransplantationHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsProspective StudiesRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesTime FactorsTreatment OutcomeConceptsPositron emission tomographyLong-term prognostic valueSerial assessmentPET-2Pet-1Cause mortalityHT patientsPrognostic valueHigh CFRLow CFRRb positron-emission tomographyEmission tomographyRb-82 positron emission tomographyRubidium-82 positron emission tomographyPET imagingHeart transplantation patientsHistory of HTCardiac allograft vasculopathyHeart transplant recipientsLong-term mortalitySingle-center studyMultivariate Cox regressionCoronary flow reserveAllograft vasculopathyHT recipientsIn Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC Basic To Translational Science 2018, 3: 378-390. PMID: 30062224, PMCID: PMC6058999, DOI: 10.1016/j.jacbts.2018.02.003.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSuperoxide productionReactive oxygen speciesMarkers of ROSNovel positron emission tomography (PET) tracerEarly detectionMyocardial superoxide productionVentricular ejection fractionDoxorubicin-induced cardiotoxicityCardiac superoxide productionPositron emission tomography (PET) tracerPositron emission tomographyEmission tomography tracerEjection fractionCancer patientsCardiotoxicity detectionEmission tomographyTomography tracerCardiotoxicityReactive oxygen species (ROS) detectionWeeksOxygen speciesRodentsEchocardiographyPatients