2019
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2019, 981-992. DOI: 10.1007/978-3-319-99375-1_98.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsCell responsesReceptor functionOlder adults
2018
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2018, 1-12. DOI: 10.1007/978-3-319-64597-1_98-1.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsReceptor functionOlder adultsYoung adults
2010
Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response. The Journal Of Immunology 2010, 184: 2518-2527. PMID: 20100933, PMCID: PMC3867271, DOI: 10.4049/jimmunol.0901022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntibodies, ViralCytokinesDendritic CellsFemaleFlow CytometryHumansInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInterleukin-12 Subunit p40Interleukin-6Linear ModelsMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionToll-Like ReceptorsTumor Necrosis Factor-alphaYoung AdultConceptsPrimary human dendritic cellsDendritic cellsHuman dendritic cellsMyeloid DCsPlasmacytoid DCsCytokine productionTLR functionTNF-alphaIntracellular cytokine productionPoor Ab responsesInfluenza vaccine responsesMyeloid dendritic cellsPlasmacytoid dendritic cellsYoung individualsIntracellular cytokine stainingIL-12 productionIFN-alpha productionTLR ligand stimulationTLR gene expressionInnate immune responseAge-Associated DecreaseTLR8 engagementInfluenza immunizationAge-associated effectsCytokine staining