2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysisModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
2015
Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure.
Redeker NS, Jeon S, Andrews L, Cline J, Jacoby D, Mohsenin V. Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure. Journal Of Clinical Sleep Medicine 2015, 11: 1109-19. PMID: 25979100, PMCID: PMC4582052, DOI: 10.5664/jcsm.5082.Peer-Reviewed Original ResearchConceptsStable heart failureHeart failureSelf-management interventionsChronic insomniaEffect of comorbidityShort-term efficacyInsomnia Severity IndexTreatment of insomniaMeasures of fatigueEffects of CBTAttention control conditionDaytime symptomsPoor functionPreliminary efficacyStable class IWrist actigraphyInsomniaPatientsClass ISeverity IndexEfficacyCBTFunctional performanceTrialsControl conditionObstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2014
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea
Jafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaFlow-mediated vasodilationVascular endothelial growth factorYKL-40/chitinaseApnea-hypopnea indexPlasma YKL-40YKL-40Endothelial dysfunctionVasodilatory capacitySleep apneaEndothelial-dependent vasodilatory capacityHypertensive OSANormotensive OSAApparent cardiovascular diseaseRisk of hypertensionProtein 1Events/hrEndothelial growth factorN-OSAVEGF receptor 1Oxygen desaturationSFlt-1Cardiovascular diseaseCommon disorderPositive correlation
2010
Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack
Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack. Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsVascular event ratesIntervention patientsSleep apneaTIA patientsVascular eventsContinuous positive airway pressure (CPAP) adherenceAcute transient ischemic attackTransient ischemic attack patientsContinuous positive airway pressurePositive airway pressure adherenceEvent ratesTransient ischemic attackPositive airway pressureCongestive heart failureMajority of patientsSleep apnea patientsIschemic attackRecurrent TIAAirflow obstructionAirway pressureControl patientsCPAP useHeart failureMyocardial infarction
2001
Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions
Mohsenin V. Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions. CHEST Journal 2001, 120: 1442-1447. PMID: 11713117, DOI: 10.1378/chest.120.5.1442.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingUpper airway sizeUpper airway dimensionsSleep apneaAirway sizeMale patientsFemale patientsAirway dimensionsUpper airwayEvaluation of SDBPrevalence of OSAPharyngeal sizeGreater total body fatMild obstructive sleep apneaUpper airway resistance syndromeSevere obstructive sleep apneaPharyngeal muscle toneUpper airway patencyEffect of obesityExcessive daytime sleepinessSimilar clinical presentationUpper airway narrowingDifferent pathogenetic mechanismsMajor risk factor
1999
Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans
DuBois A, Kelley P, Douglas J, Mohsenin V. Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans. Journal Of Applied Physiology 1999, 86: 159-167. PMID: 9887126, DOI: 10.1152/jappl.1999.86.1.159.Peer-Reviewed Original ResearchQuality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study
D’Ambrosio C, Bowman T, Mohsenin V. Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study. CHEST Journal 1999, 115: 123-129. PMID: 9925072, DOI: 10.1378/chest.115.1.123.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaQuality of lifeMental healthMedical Outcomes Study Short Form-36 questionnaireNasal continuous positive airway pressure treatmentEffect of OSAContinuous positive airway pressure (CPAP) treatmentNasal continuous positive airway pressureDiagnosis of OSASocial functioningPositive airway pressure treatmentContinuous positive airway pressureShort Form-36 questionnaireEffect of nCPAPPositive airway pressureRespiratory disturbance indexSleep-disordered breathingBody mass indexEvents/hGender-matched populationCase series analysisSeverity of diseaseMagnitude of improvementNCPAP levelNCPAP therapy
1998
Production and absorption of nitric oxide gas in the nose
Dubois A, Douglas J, Stitt J, Mohsenin V. Production and absorption of nitric oxide gas in the nose. Journal Of Applied Physiology 1998, 84: 1217-1224. PMID: 9516187, DOI: 10.1152/jappl.1998.84.4.1217.Peer-Reviewed Original ResearchSLEEP IN ASTHMA
D'Ambrosio C, Mohsenin V. SLEEP IN ASTHMA. Clinics In Chest Medicine 1998, 19: 127-137. PMID: 9554223, DOI: 10.1016/s0272-5231(05)70437-8.Peer-Reviewed Original Research
1995
Effect of nitrous acid on lung function in asthmatics: a chamber study.
Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.Peer-Reviewed Original ResearchConceptsSignificant airflow obstructionChamber exposure studiesFiltered room airModerate cycle exerciseNitrous acid exposureIndoor nitrogen dioxideMucous membrane symptomsDuration of exposureAirflow obstructionLung functionIrritant symptomsVital capacityCycle exerciseLung mechanicsRespiratory effectsAcid exposureRespiratory parametersAdult subjectsRoom airHealth effectsSymptomsSignificant decreaseAsthmaticsExposure studiesCommon indoor air pollutantsSleep apnea in patients with hemispheric stroke
Mohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Archives Of Physical Medicine And Rehabilitation 1995, 76: 71-76. PMID: 7811179, DOI: 10.1016/s0003-9993(95)80046-8.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingHemispheric strokeCerebral symptomsSleep apneaStroke patientsRapid eye movement (REM) sleepArterial oxygen desaturationComplications of strokePresence of hypertensionRespiratory disturbance indexBody mass indexAbnormal sleep architectureEye movement sleepSlow-wave sleepOxygen desaturationGroups of subjectsBrainstem lesionsCerebrovascular accidentCerebral strokeMass indexRespiratory disturbancesRespiratory eventsMovement sleepSleep architecturePrior history
1994
Daytime oxygen saturation does not predict nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease
Mohsenin V, Guffanti E, Hilbert J, Ferranti R. Daytime oxygen saturation does not predict nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease. Archives Of Physical Medicine And Rehabilitation 1994, 75: 285-289. PMID: 8129580, DOI: 10.1016/0003-9993(94)90030-2.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseNocturnal oxygen desaturationObstructive pulmonary diseaseOxygen desaturationAwake SaO2Nocturnal hypoxemiaPulmonary diseaseOxygen saturationDaytime oxygen saturationArterial oxygen saturationControl of breathingNocturnal SaO2COPD patientsPulmonary hypertensionAwake patientsPathologic mechanismsIndividual patientsNocturnal oximetryCardiac arrhythmiasPatientsSaO2HypoxemiaDesaturationOximetryDisease
1991
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses
Mohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.Peer-Reviewed Original ResearchConceptsElastase inhibitory capacityAlveolar lining fluidLipid peroxidation productsLining fluidLavage fluidVitamin-supplemented groupOxidant stressLipid peroxidationPeroxidation productsControl groupLower respiratory tract fluidFour-week supplementationVitamin CRespiratory tract fluidNO2 exposureInactivation of alphaConjugated dienesVitamin supplementationNormal subjectsAntielastase activityInhibitory capacityOxidant exposureSignificant decreaseAntioxidant defensePeroxidation
1990
Respiratory burst in alveolar macrophages of diabetic rats
Mohsenin V, Latifpour J. Respiratory burst in alveolar macrophages of diabetic rats. Journal Of Applied Physiology 1990, 68: 2384-2390. PMID: 2166735, DOI: 10.1152/jappl.1990.68.6.2384.Peer-Reviewed Original ResearchConceptsPeripheral blood monocytesPhorbol myristate acetateAlveolar macrophagesBlood monocytesInduction of diabetesPMA stimulationEnzyme cycling methodDismutase-inhibitable cytochrome c reductionSuperoxide dismutase-inhibitable cytochrome c reductionNeutrophil O2Diabetes mellitusDiabetic ratsRats 8Basal conditionsDiabeticsAnion generationMacrophagesMyristate acetateMonocytesSignificant differencesDiabetesStimulationCytochrome c reductionRatsRespiratory
1988
Bilateral diaphragmatic paralysis: clinical spectrum, prognosis, and diagnostic approach.
Chan C, Loke J, Virgulto J, Mohsenin V, Ferranti R, Lammertse T. Bilateral diaphragmatic paralysis: clinical spectrum, prognosis, and diagnostic approach. Archives Of Physical Medicine And Rehabilitation 1988, 69: 976-9. PMID: 3190422.Peer-Reviewed Original ResearchConceptsBilateral diaphragmatic paralysisDiaphragmatic paralysisAcute respiratory failurePulmonary function testsRestrictive ventilatory defectSevere respiratory insufficiencyArterial blood gasGood quality survivalChronic respiratory acidosisCardiopulmonary decompensationCor pulmonaleDiaphragmatic impairmentRespiratory failureRespiratory insufficiencyVentilatory defectClinical courseRetrospective reviewAppropriate therapyFunction testsCardiopulmonary statusUnderdiagnosed conditionClinical spectrumRespiratory acidosisBlood gasSupine positionAirway responsiveness and prostaglandin generation in scorbutic guinea pigs.
Mohsenin V, Tremml P, Rothberg K, Souhrada M, Douglas J. Airway responsiveness and prostaglandin generation in scorbutic guinea pigs. Prostaglandins Leukotrienes And Essential Fatty Acids 1988, 33: 149-55. PMID: 3186781.Peer-Reviewed Original ResearchConceptsAirway smooth muscleAirway hyperresponsivenessProstaglandin generationGuinea pigsAirway responsivenessHistamine aerosolSmooth muscleScorbutic guinea pigsAscorbic acid-deficient dietSignificant airway hyperresponsivenessScorbutic animalsSodium pump activityElectrogenic sodium pump activityAscorbic acid deficiencyProstanoid generationLung parenchymaDeficient dietElectrophysiological characteristicsControl animalsHyperresponsivenessAcid deficiencyControl groupElectrophysiological propertiesScorbutic conditionLungAirway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects
Mohsenin V. Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects. Archives Of Environmental & Occupational Health 1988, 43: 242-246. PMID: 3289507, DOI: 10.1080/00039896.1988.9934941.Peer-Reviewed Original ResearchConceptsSpecific airway conductanceLung function testsAirway reactivityMethacholine aerosolAirway conductanceFunction testsVital capacityNormal subjectsDouble-blind randomized fashionPartial expiratory flowDose of methacholineConcentration of methacholineAcute respiratory responsesFunctional residual capacityPpm nitrogen dioxideAirway responsesMethacholine inhalationExpiratory volumeRespiratory symptomsNormal nonsmokersExpiratory flowLung volumeRandomized fashionRespiratory responsesResidual capacity
1987
Airway responses to nitrogen dioxide in asthmatic subjects
Mohsenin V. Airway responses to nitrogen dioxide in asthmatic subjects. Journal Of Toxicology And Environmental Health 1987, 22: 371-380. PMID: 3320381, DOI: 10.1080/15287398709531080.Peer-Reviewed Original ResearchConceptsAirway reactivityVital capacityAsthmatic subjectsDouble-blind randomized fashionPartial expiratory flowSpecific airway conductanceDose of methacholineNO2 exposureFunctional residual capacityAirway conductanceAirway responsesMethacholine inhalationExpiratory volumeLung functionExpiratory flowSignificant potentiationSignificant symptomsRandomized fashionRespiratory responsesResidual capacityAsthmaticsCommon indoor air pollutantsExposureSignificant changesDifferent days