2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damage
2001
Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions
Mohsenin V. Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions. CHEST Journal 2001, 120: 1442-1447. PMID: 11713117, DOI: 10.1378/chest.120.5.1442.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingUpper airway sizeUpper airway dimensionsSleep apneaAirway sizeMale patientsFemale patientsAirway dimensionsUpper airwayEvaluation of SDBPrevalence of OSAPharyngeal sizeGreater total body fatMild obstructive sleep apneaUpper airway resistance syndromeSevere obstructive sleep apneaPharyngeal muscle toneUpper airway patencyEffect of obesityExcessive daytime sleepinessSimilar clinical presentationUpper airway narrowingDifferent pathogenetic mechanismsMajor risk factor