Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple-clone Plasmodium falciparum infections in northern Tanzania.
Ferreira M, Liu Q, Kimura M, Ndawi B, Tanabe K, Kawamoto F. Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple-clone Plasmodium falciparum infections in northern Tanzania. Journal Of Parasitology 1998, 84: 1286-9. PMID: 9920333, DOI: 10.2307/3284693.Peer-Reviewed Original ResearchConceptsMerozoite surface protein 1MSP-1 gene typesSurface protein 1Type-specific polymerase chain reactionMajor malaria vaccine candidatePlasmodium falciparum infectionProtein 1Malaria vaccine candidateMsp-1 geneP. falciparum populationsMost patientsFalciparum infectionPolymerase chain reactionDistinct parasite populationsVaccine candidatesClinical isolatesAllelic typesGene typesPlasmodium falciparumNorthern TanzaniaChain reactionPatientsEpidemiological consequencesRecent findingsParasite populationsAllelic Diversity at the Merozoite Surface Protein-1 (MSP-1) Locus in Natural Plasmodium falciparum Populations: a Brief Overview
Ferreira M, Kaneko O, Kimura M, Liu Q, Kawamoto F, Tanabe K. Allelic Diversity at the Merozoite Surface Protein-1 (MSP-1) Locus in Natural Plasmodium falciparum Populations: a Brief Overview. Memórias Do Instituto Oswaldo Cruz 1998, 93: 631-638. PMID: 9830530, DOI: 10.1590/s0074-02761998000500013.Peer-Reviewed Original ResearchConceptsMSP-1 gene typesProtein-1 locusMerozoite surface protein-1 locusNon-random associationGene typesAllelic diversityParasite populationsAllelic typesSingle-copy geneFrequency-dependent immune selectionNatural Plasmodium falciparum populationsMsp-1 locusLocal parasite populationMsp-1 allelic typesDifferent gene typesPlasmodium falciparum populationsVariable blocks 2Wild isolatesSelective pressureSouthwestern Brazilian AmazonExtensive polymorphismLociHuman hostMajor malaria vaccine candidateImmune selectionStable Patterns of Allelic Diversity at the Merozoite Surface Protein‐1 Locus of Plasmodium falciparum in Clinical Isolates from Southern Vietnam
Ferreira M, Liu Q, Zhou M, Kimura M, Kaneko O, Van Thien H, Isomura S, Tanabe K, Kawamoto F. Stable Patterns of Allelic Diversity at the Merozoite Surface Protein‐1 Locus of Plasmodium falciparum in Clinical Isolates from Southern Vietnam. Journal Of Eukaryotic Microbiology 1998, 45: 131-136. PMID: 9495041, DOI: 10.1111/j.1550-7408.1998.tb05080.x.Peer-Reviewed Original ResearchConceptsPlasmodium falciparumFrequency-dependent immune selectionSame endemic areaMerozoite surface protein-1 locusSymptomatic patientsParasite populationsPolymerase chain reactionArea 17Endemic areasMesoendemic areaGene typesClinical isolatesAllelic typesPatientsImmune selectionDifferent gene typesChain reactionDistinct subpopulationsFalciparumPresent studyProtein-1 locusIsolatesPopulationPrevalenceAverage number