2009
WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis
Vuga LJ, Ben-Yehudah A, Kovkarova-Naumovski E, Oriss T, Gibson KF, Feghali-Bostwick C, Kaminski N. WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis. American Journal Of Respiratory Cell And Molecular Biology 2009, 41: 583-589. PMID: 19251946, PMCID: PMC2778165, DOI: 10.1165/rcmb.2008-0201oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBeta CateninBlotting, WesternCase-Control StudiesCaspase 3Cell LineCell ProliferationCell SurvivalFibroblastsFibronectinsGene Expression ProfilingHumansHydrogen PeroxideIdiopathic Pulmonary FibrosisIntegrin alpha5LungMiceOligonucleotide Array Sequence AnalysisProto-Oncogene ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNA InterferenceTransfectionUp-RegulationWnt ProteinsWnt-5a ProteinConceptsUsual interstitial pneumoniaNormal lung fibroblastsLung tissueLung fibroblastsFibrotic interstitial lung diseaseInterstitial lung fibrosisSpecific histopathologic patternIdiopathic pulmonary fibrosisInterstitial lung diseaseRole of Wnt5aReal-time RT-PCRQuantitative real-time RT-PCRInterstitial pneumoniaPulmonary fibrosisAutoimmune diseasesHistopathologic patternLung diseaseLung fibrosisHistological patternNormal histologyWnt/beta-catenin pathwayCanonical Wnt/beta-catenin pathwayWestern blotFibroblast proliferationBeta-catenin pathway
2003
Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines
Margalit O, Eisenbach L, Amariglio N, Kaminski N, Harmelin A, Pfeffer R, Shohat M, Rechavi G, Berger R. Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. British Journal Of Cancer 2003, 89: 314-319. PMID: 12865923, PMCID: PMC2394268, DOI: 10.1038/sj.bjc.6600977.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCarrier ProteinsCCN Intercellular Signaling ProteinsFemaleGene Expression Regulation, NeoplasticGrowth SubstancesHumansIntracellular Signaling Peptides and ProteinsLung NeoplasmsMaleMelanomaMiceMice, Inbred C57BLNeoplasm MetastasisOligonucleotide Array Sequence AnalysisOncogene ProteinsPlasminogen Activator Inhibitor 2Polymerase Chain ReactionProto-Oncogene ProteinsTumor Cells, CulturedUteroglobinConceptsPlasminogen activator inhibitor-2Melanoma cell linesBrain natriuretic peptidePulmonary metastasesSet of genesLewis lung carcinomaWISP-1Cell linesSurfactant protein CMetastatic processReal-time quantitative PCRLung carcinomaOligonucleotide microarraysMicroarray analysisInhibitor 2GenesGenetic determinantsSpontaneous pulmonary metastasesIL-1 alphaMinimal residual diseaseProtein 1Cause of deathDevelopment of metastasesInterleukin-1 alphaQuantitative PCR