2019
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura M, Lecuona E, Angulo M, Dada LA, Edwards MB, Welch LC, Casalino-Matsuda SM, Sporn PHS, Vadász I, Helenius IT, Nader GA, Gruenbaum Y, Sharabi K, Cummins E, Taylor C, Bharat A, Gottardi CJ, Beitel GJ, Kaminski N, Budinger GRS, Berdnikovs S, Sznajder JI. Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans. Scientific Reports 2019, 9: 18251. PMID: 31796806, PMCID: PMC6890671, DOI: 10.1038/s41598-019-54683-0.Peer-Reviewed Original ResearchConceptsLarge-scale transcriptomic studyAvailable transcriptomic datasetsCell linesWnt pathway genesOrganismal functionDrosophila melanogasterElevated CO2Different tissue originsTranscriptomic studiesBronchial cell lineCO2 elevationTranscriptomic datasetsGenomic responsesHuman bronchial cell linePathway genesGene expressionDifferent tissuesGenesHigh CO2Tissue originMammalsSkeletal musclePathwayCaenorhabditisMelanogaster
2015
Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy*
Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy*. Journal Of Biological Chemistry 2015, 290: 29742-29757. PMID: 26494620, PMCID: PMC4705969, DOI: 10.1074/jbc.m115.691253.Peer-Reviewed Original ResearchConceptsSpontaneous pulmonary fibrosisPulmonary fibrosisΑ1-antitrypsin ZPathological effectsSevere pulmonary fibrosisRespiratory epithelial cellsPiZ miceRestrictive deficitsActivation of autophagyLeukocyte infiltrationSurfactant protein AAnimal modelsC deficiencyFibrosisProteinopathiesSkeletal muscleEpithelial cellsIntracellular accumulationAutophagolysosomal systemLungMiceAttractive targetAutophagyDrugsRecent studies
2005
Effects of Aerobic Training on Gene Expression in Skeletal Muscle of Elderly Men
RADOM-AIZIK S, HAYEK S, SHAHAR I, RECHAVI G, KAMINSKI N, BEN-DOV I. Effects of Aerobic Training on Gene Expression in Skeletal Muscle of Elderly Men. Medicine & Science In Sports & Exercise 2005, 37: 1680-1696. PMID: 16260967, DOI: 10.1249/01.mss.0000181838.96815.4d.Peer-Reviewed Original ResearchConceptsGene expressionGlobal gene expressionSkeletal muscleExpression of genesCatabolism genesTranscriptional responseHeme biosynthesisMonths of trainingElderly menGeneChip arraysGenesEnergy metabolismHealthy elderly menPeak O2 uptakeExpressionProtein catabolismPathwayAerobic trainingNeedle biopsyPhysical activityEnergy pathwaysVastus lateralisBeneficial effectsDephosphorylationRibosomes