2015
Asbestosis and environmental causes of usual interstitial pneumonia
Gulati M, Redlich CA. Asbestosis and environmental causes of usual interstitial pneumonia. Current Opinion In Pulmonary Medicine 2015, 21: 193-200. PMID: 25621562, PMCID: PMC4472384, DOI: 10.1097/mcp.0000000000000144.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisUsual interstitial pneumoniaInterstitial pneumoniaDevelopment of IPFUsual interstitial pneumonia patternRecent epidemiologic investigationsEnvironmental exposuresFibrotic lung diseaseInterstitial pneumonia patternExposure-disease relationshipsIPF patientsPneumonia patternClinical courseIPF diagnosisPulmonary fibrosisHistopathologic patternLung diseaseAsbestos exposureRadiographic changesOverall burdenAsbestosis patientsClinical challengeEpidemiologic studiesCase controlAgricultural exposures
2011
Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis
Peng X, Mathai SK, Murray LA, Russell T, Reilkoff R, Chen Q, Gulati M, Elias JA, Bucala R, Gan Y, Herzog EL. Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis. Fibrogenesis & Tissue Repair 2011, 4: 12. PMID: 21586112, PMCID: PMC3123188, DOI: 10.1186/1755-1536-4-12.Peer-Reviewed Original ResearchFibrotic lung diseasePulmonary fibrosisLung diseaseApoptotic cell death responseCell death responseCollagen productionTGF-β1Connective tissue disease-related interstitial lung diseaseInhibition of apoptosisDeath responseCaspase activationIdiopathic pulmonary fibrosisCaspase inhibitorsInterstitial lung diseaseMonocyte-derived cellsHealthy normal controlsHuman transforming growth factorTransforming Growth FactorCaspase blockadeCell surface phenotypeGrowth factor-β1Cultured cellsLevel of apoptosisLung fibrosisApoptosis
2010
Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages
Murray LA, Rosada R, Moreira AP, Joshi A, Kramer MS, Hesson DP, Argentieri RL, Mathai S, Gulati M, Herzog EL, Hogaboam CM. Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages. PLOS ONE 2010, 5: e9683. PMID: 20300636, PMCID: PMC2837381, DOI: 10.1371/journal.pone.0009683.Peer-Reviewed Original ResearchConceptsSerum amyloid PPulmonary fibrosisAmyloid PIPF/UIP patientsBleomycin-Induced Pulmonary FibrosisIP10/CXCL10Fibrotic lung diseaseAberrant collagen depositionRole of macrophagesM2 macrophage phenotypeUIP patientsLung diseaseM2 macrophagesCollagen depositionTissue fibrosisMacrophage activationMacrophage phenotypeFcgamma receptorsMacrophage responsePentraxin familyTherapeutic actionFibrosisMacrophagesLungTissue remodeling