2024
Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease
Swaminathan A, McFatrich M, Mkumba L, Wright L, Redlich C, Snyder L, Reeve B, Patel D, Gulati M. Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease. Respiratory Research 2024, 25: 372. PMID: 39407223, PMCID: PMC11481565, DOI: 10.1186/s12931-024-03000-z.Peer-Reviewed Original ResearchConceptsCognitive interviewsContent validityExposure questionnaireMultidisciplinary teamSemi-structured interview guideEvidence of content validityFibrosing ILDsInterstitial lung diseaseRelevant exposuresFibrotic interstitial lung diseaseClinically relevant exposuresTrained interviewersInterview guideAssessment QuestionnaireQuestionnaireInterviewsLung diseaseAdultsTeamClinicPatientsSource of misunderstandingOccupational inhalation exposureValidityDisease
2023
EVALUATION OF CONTENT VALIDITY OF A NEW EXPOSURE ASSESSMENT QUESTIONNAIRE IN PATIENTS WITH FIBROSING INTERSTITIAL LUNG DISEASES
SWAMINATHAN A, MCFATRICH M, MKUMBA L, WRIGHT L, REDLICH C, SNYDER L, REEVE B, OLSON A, GULATI M. EVALUATION OF CONTENT VALIDITY OF A NEW EXPOSURE ASSESSMENT QUESTIONNAIRE IN PATIENTS WITH FIBROSING INTERSTITIAL LUNG DISEASES. CHEST Journal 2023, 164: a5103-a5104. DOI: 10.1016/j.chest.2023.07.3304.Peer-Reviewed Original ResearchAutoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program
Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.Peer-Reviewed Original ResearchCase-control studyAutoimmune diseasesSarcoidosis patientsMultivariable analysisOdds ratioSarcoidosis casesUs Research ProgramDiverse cohortConcomitant autoimmune diseasesRace-matched controlsMultiple autoimmune diseasesAutoimmune comorbiditiesSarcoidosisPatientsLogistic regressionDiseaseSmall sample sizeCareful screeningCohortAssociationSample sizeComposite variablePrior studiesComorbiditiesStudy
2022
Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study
Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Respiratory Medicine 2022, 200: 106923. PMID: 35932543, DOI: 10.1016/j.rmed.2022.106923.Peer-Reviewed Original ResearchConceptsAlpha-1 antitrypsin deficiencyCardiac sarcoidosisSarcoidosis StudyAntitrypsin deficiencyRadiation exposureNon-cardiac sarcoidosisNon-chronic diseasesMultiple comparisonsEnvironmental exposure dataExtrapulmonary diseasePulmonary involvementGranulomatous disorderSarcoidosis phenotypesRisk factorsSpecific disease phenotypesStage 0Number of exposuresSarcoidosisExposure assessment toolsSusceptible individualsSpecific exposuresDiseaseEnvironmental exposuresExposure dataIndividual exposureOccupational Exposome and Lung Health
MacMurdo M, Culver D, Gulati M. Occupational Exposome and Lung Health. Respiratory Medicine 2022, 51-91. DOI: 10.1007/978-3-030-90185-1_4.Peer-Reviewed Original ResearchOccupational lung diseaseLung diseaseChronic occupational lung diseaseSecondary disease preventionPublic health providersRespiratory morbidityLung healthRespiratory healthWorkplace exposuresHealth providersDisease preventionDiseaseMultidisciplinary approachKey pathwaysPreventionExposomeHealthExposureMorbiditySignificant contributorMortalityCliniciansOccupational Interstitial Lung Disease
Gulati M, Maier L. Occupational Interstitial Lung Disease. 2022, 368-380. DOI: 10.1016/b978-0-12-801238-3.11503-x.Peer-Reviewed Original ResearchInterstitial lung diseaseLung diseaseRelated interstitial lung diseaseOccupational interstitial lung diseaseIdiopathic interstitial pneumoniaSecondary prevention programsRespiratory surveillance programLocal health departmentsDisease-exposure relationshipsCoal workers' pneumoconiosisInterstitial pneumoniaPathologic patternsPersonal protection equipmentDifferential diagnosisHealth departmentsPrevention programsSpecific exposuresSurveillance programConsideration of exposureHealth agenciesDiseaseRelevant exposuresExposure relationshipExposure historySimilar diseases
2019
Patient Registries in Idiopathic Pulmonary Fibrosis
Culver DA, Behr J, Belperio JA, Corte TJ, de Andrade JA, Flaherty KR, Gulati M, Huie TJ, Lancaster LH, Roman J, Ryerson CJ, Kim HJ. Patient Registries in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 160-167. PMID: 31034241, PMCID: PMC6635784, DOI: 10.1164/rccm.201902-0431ci.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisPatient RegistryPrecision medicine approachQuality of lifeThousands of patientsClinical characteristicsRegistry databasePatient populationLarge registriesDisease progressionClinical trialsPatient profilesRare diseasePatientsRegistryDisease severityMedicine approachFibrosisDiseaseAnalysis of biospecimensBroad spectrumCurrent practiceComorbiditiesLongitudinal dataPlasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.Peer-Reviewed Original ResearchConceptsExtrapulmonary diseaseMitochondrial DNAExtracellular mtDNABAL fluidAlpha-1 antitrypsin deficiencyPlasma mitochondrial DNAPlasma of patientsAfrican AmericansExtrapulmonary sarcoidosisSarcoidosis cohortSarcoidosis subjectsScadding stageAfrican American descentClinical featuresClinical findingsGranulomatous diseaseHealthy controlsAntitrypsin deficiencyGenomic researchHigher oddsSarcoidosisAggressive phenotypeMechanistic basisDiseaseTherapeutic insightsCirculating Mitochondrial DNA Is Associated with Fibroblast Activation and Disease Progression in Scleroderma Associated Interstitial Lung Disease
Ryu C, Sun H, Winkler J, Meena S, Walia A, Minasyan M, Brandsdorfer C, Gulati M, Peng X, Herzog E. Circulating Mitochondrial DNA Is Associated with Fibroblast Activation and Disease Progression in Scleroderma Associated Interstitial Lung Disease. 2019, a7219-a7219. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7219.Peer-Reviewed Original Research
2017
Occupational lung diseases: from old and novel exposures to effective preventive strategies
Cullinan P, Muñoz X, Suojalehto H, Agius R, Jindal S, Sigsgaard T, Blomberg A, Charpin D, Annesi-Maesano I, Gulati M, Kim Y, Frank AL, Akgün M, Fishwick D, de la Hoz RE, Moitra S. Occupational lung diseases: from old and novel exposures to effective preventive strategies. The Lancet Respiratory Medicine 2017, 5: 445-455. PMID: 28089118, DOI: 10.1016/s2213-2600(16)30424-6.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseCommon occupational lung diseaseNon-communicable lung diseasesWork-related asthmaEffective preventive strategiesMalignant lung diseaseOccupational exposurePreventive strategiesRespiratory diseaseAsthmaControl measuresDiseaseNovel exposureShort latencyGlobal causeIncidenceExposureHeavy burdenBurdenRiskManagement of workersCauseProximal causeRapid economic transitionLung Diseases, Occupational
Gulati M, Cullen M. Lung Diseases, Occupational. 2017, 485-490. DOI: 10.1016/b978-0-12-803678-5.00261-7.Peer-Reviewed Original Research
2014
Pulmonary Fibrosis
Murray L, Homer R, Gulati M, Herzog E. Pulmonary Fibrosis. 2014, 2636-2653. DOI: 10.1016/b978-0-12-386456-7.05307-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInterstitial lung diseasePulmonary fibrosisLung fibrosisConnective tissue disease-related interstitial lung diseaseIdiopathic pulmonary fibrosisSalient clinical featuresDistinctive pathological featuresWound healing responseClinical featuresChronic injuryLung diseasePathological featuresCirculating BiomarkersInflammatory responseLung parenchymaCertain therapiesPathogenic mechanismsScar tissueClinical monitoringFibrosisHealing responseFatal natureGenetic formsDiseasePotential role
2012
Newly Recognized Occupational and Environmental Causes of Chronic Terminal Airways and Parenchymal Lung Disease
Sauler M, Gulati M. Newly Recognized Occupational and Environmental Causes of Chronic Terminal Airways and Parenchymal Lung Disease. Clinics In Chest Medicine 2012, 33: 667-680. PMID: 23153608, PMCID: PMC3515663, DOI: 10.1016/j.ccm.2012.09.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParenchymal lung diseaseExposure-disease relationshipsLung diseaseTerminal airwaysDiffuse parenchymal lung diseaseWorld Trade Center disasterChronic formHigh indexNovel exposureDiseaseEnvironmental exposuresHealth investigatorsWorker surveillanceAirwayExposureEnvironmental causesPotential toxicityCliniciansSuspicionNylon flockBiomarkers
2011
Diagnostic assessment of patients with interstitial lung disease
Gulati M. Diagnostic assessment of patients with interstitial lung disease. Npj Primary Care Respiratory Medicine 2011, 20: 120-127. PMID: 21509417, PMCID: PMC6549811, DOI: 10.4104/pcrj.2010.00079.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseChronic obstructive pulmonary diseaseLung diseaseSurgical lung biopsyObstructive pulmonary diseaseConnective tissue diseasePrimary care settingHistory of symptomsTomography chest scanILD formsLung biopsyRespiratory symptomsPulmonary diseaseClinical cluesPulmonary diagnosisTissue diseaseILD casesPhysical examinationDrug exposureGeneral practitionersDiagnostic evaluationCare settingsStructured historyChest scansDisease
2009
Healthcare for Obstructive Lung Disease in an Industrial Spirometry Surveillance Program
Gulati M, Slade MD, Fiellin MG, Cullen MR. Healthcare for Obstructive Lung Disease in an Industrial Spirometry Surveillance Program. Journal Of Occupational And Environmental Medicine 2009, 51: 336-342. PMID: 19225419, PMCID: PMC3711683, DOI: 10.1097/jom.0b013e3181954ae6.Peer-Reviewed Original ResearchConceptsAirflow obstructionObstructive lung diseaseLung diseaseSurveillance programUndiagnosed airflow obstructionHealth careAluminum production workersAluminum industry workersCross-sectional analysisRespiratory surveillanceMild obstructionLung functionPrimary outcomeBorderline obstructionPresence of claimsObstructionIndustry workersSectional analysisDiseaseFurther investigationCareInsurance claimsProduction workersWorkersSeverity
2008
Lung Diseases, Occupational
Gulati M, Cullen M. Lung Diseases, Occupational. 2008, 157-163. DOI: 10.1016/b978-012373960-5.00298-7.Peer-Reviewed Original Research